Results 161 to 170 of about 144,829 (355)
Biotechnology and Bioengineering, EarlyView.A platform approach to the affinity capture and enrichment of host cell proteins to enable their subsequent deep characterization and elucidation of variants or proteoforms (e.g., molecular size variants, charge variants, glycoforms, etc.). ABSTRACT Removing host cell proteins (HCPs) during biotherapeutic manufacturing is essential to ensure patient ...
Michael E. Dolan +6 more
wiley +1 more source
Automated glycan assembly of oligomannose glycans for sensing applications
, 2017 Carbohydrates are useful building blocks for supramolecular assemblies offering the possibility of multiple hydrogen bonding. Several carbohydrate- functionalized multivalent scaffolds have been used to study weak carbohydrate-protein (CPIs) and carbohydrate-carbohydrate interactions (CCIs).
openaire +2 more sources
Exosome as bioactive nanovesicle for diagnostic and therapeutic applications in periodontitis
BMEMat, EarlyView.This review introduces the mechanism that exosomes participate in the pathogenesis of periodontitis and their potential as biomarkers for early diagnosis and summarizes the application of cell‐ or plant‐derived exosomes or engineered exosomes in periodontitis or periodontal regeneration while proposing the perspective of translational application of ...
Yu Wang +6 more
wiley +1 more source
Biological Diversity, EarlyView.A proactive, predictive, and integrative framework that integrates multi‐omics innovations with ecological modeling and big data analytics to guide adaptive interventions and governance in invasive species management. By integrating multi‐omics insights with advanced ecological modeling, remote sensing, artificial intelligence, and cross‐disciplinary ...
Aibin Zhan
wiley +1 more source
Dynamic pH profiles drive higher cell‐specific and volumetric productivity
Biotechnology Progress, EarlyView.Implementation of dyamic pH profiles for increased CHO cell culture productivity. Abstract Mammalian cell cultures in bioreactors rely heavily on critical process parameter control to ensure optimal growth, productivity, and reproducibility to produce recombinant therapeutic proteins. Culture pH has been shown to be a critical parameter that influences
Stephanie R. Klaubert +6 more
wiley +1 more source
Single-molecule imaging of glycan–lectin interactions on cells with Glyco-PAINT
, 2021 Roger Riera +8 more
openalex +2 more sources
Biotechnology Progress, EarlyView.Abstract Artificial intelligence and automation are no longer just buzzwords in the biopharmaceutical industry. The manufacturing of a class of biologics, comprising monoclonal antibodies, cell therapies, and gene therapies, is far more complex than that of traditional small molecule drugs.
Shyam Panjwani, Hao Wei, John Mason
wiley +1 more source
Enhancing CHO cell recombinant protein production using a perfusion‐directed host evolution approach
Biotechnology Progress, EarlyView.Abstract Clonally derived cell lines generated from Chinese hamster ovary (CHO) cells encounter numerous stressors when cultured in high‐intensity perfusion bioreactors leading to poor process performance. To circumvent this, the ability of CHO cells to adapt to different culture environments was exploited. Here host cells were selected in the presence
Peter Amaya +7 more
wiley +1 more source