Results 21 to 30 of about 172,036 (354)
Mucin-Type O-Glycosylation in the Drosophila Nervous System
Frontiers in Neuroanatomy, 2021 Mucin-type O-glycosylation, a predominant type of O-glycosylation, is an evolutionarily conserved posttranslational modification in animals. Mucin-type O-glycans are often found on mucins in the mucous membranes of the digestive tract.
Kazuyoshi Itoh +2 more
doaj +1 more source
Glycans and Glycan-Binding Proteins in Atherosclerosis [PDF]
Thrombosis and Haemostasis, 2019 AbstractComplex glycans are readily accessible on the endothelium and on cell and plasma components. They interact with glycan-binding proteins which translate their structure into function. Advanced analytical tools are available to investigate their structure and functional interactions.
Veit Eckardt +2 more
openaire +2 more sources
Investigating virus–glycan interactions using glycan microarrays [PDF]
Current Opinion in Virology, 2014 While all viruses must transit the plasma membrane of mammalian cells to initiate infection, we know little about the complex processes involved in viral attachment, which commonly involve recognition of glycans by viral proteins. Glycan microarrays derived from both synthetic glycans and natural glycans isolated through shotgun glycomics approaches ...
David F, Smith, Richard D, Cummings
openaire +2 more sources
Characterization of recombinant human lactoferrin N-glycans expressed in the milk of transgenic cows. [PDF]
, 2017 Lactoferrin (LF) is one of the most abundant bioactive glycoproteins in human milk. Glycans attached through N-glycosidic bonds may contribute to Lactoferrin functional activities. In contrast, LF is present in trace amounts in bovine milk.
Barile, Daniela +5 more
core +8 more sources
Frontiers in Immunology, 2023 BackgroundThe new types of mRNA-containing lipid nanoparticle vaccines BNT162b2 and mRNA-1273 and the adenovirus-based vaccine AZD1222 were developed against SARS-CoV-2 and code for its spike (S) protein.
Jana Sophia Buhre +23 more
doaj +1 more source
Glycan microarrays of fluorescently-tagged natural glycans [PDF]
Glycoconjugate Journal, 2015 This review discusses the challenges facing research in 'functional glycomics' and the novel technologies that are being developed to advance the field. The structural complexity of glycans and glycoconjugates makes studies of both their structures and recognition difficult. However, these intricate structures can be captured from their natural sources,
Xuezheng, Song +3 more
openaire +2 more sources
Frontiers in Plant Science, 2022 Glycoproteins are the dominant category among approved biopharmaceuticals, indicating their importance as therapeutic proteins. Glycoproteins are decorated with carbohydrate structures (or glycans) in a process called glycosylation.
Alex van der Kaaij +4 more
doaj +1 more source
An Efficient and Economical N-Glycome Sample Preparation Using Acetone Precipitation
Metabolites, 2022 Due to the critical role of the glycome in organisms and its close connections with various diseases, much time and effort have been dedicated to glycomics-related studies in the past decade.
Junyao Wang +4 more
doaj +1 more source
Protein glycosylation as a diagnostic and prognostic marker of chronic inflammatory gastrointestinal and liver diseases [PDF]
, 2020 Glycans are sequences of carbohydrates that are added to proteins or lipids to modulate their structure and function. Glycans modify proteins required for regulation of immune cells, and alterations have been associated with inflammatory conditions.
Callewaert, Nico +6 more
core +1 more source
Rationally designed immunogens enable immune focusing following SARS-CoV-2 spike imprinting
Cell Reports, 2022 Summary: Eliciting antibodies to surface-exposed viral glycoproteins can generate protective responses that control and prevent future infections. Targeting conserved sites may reduce the likelihood of viral escape and limit the spread of related viruses
Blake M. Hauser +12 more
doaj +1 more source