Results 21 to 30 of about 144,829 (355)
CH-π Interactions in Glycan Recognition.
ACS Chemical Biology, 2021 Carbohydrate recognition is crucial for biological processes ranging from development to immune system function to host-pathogen interactions. The proteins that bind glycans are faced with a daunting task: to coax these hydrophilic species out of water ...
L. Kiessling, Roger C. Diehl
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Glycan microarrays of fluorescently-tagged natural glycans [PDF]
Glycoconjugate Journal, 2015 This review discusses the challenges facing research in 'functional glycomics' and the novel technologies that are being developed to advance the field. The structural complexity of glycans and glycoconjugates makes studies of both their structures and recognition difficult. However, these intricate structures can be captured from their natural sources,
Xuezheng, Song +3 more
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Frontiers in Immunology, 2023 BackgroundThe new types of mRNA-containing lipid nanoparticle vaccines BNT162b2 and mRNA-1273 and the adenovirus-based vaccine AZD1222 were developed against SARS-CoV-2 and code for its spike (S) protein.
Jana Sophia Buhre +23 more
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Glycan Labeling and Analysis in Cells and In Vivo.
Annual Review of Analytical Chemistry, 2021 As one of the major types of biomacromolecules in the cell, glycans play essential functional roles in various biological processes. Compared with proteins and nucleic acids, the analysis of glycans in situ has been more challenging.
Bo Cheng, Qi Tang, Che Zhang, Xing Chen
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Glycan Fingerprints: Calculating Diversity in Glycan Libraries [PDF]
ACS Chemical Biology, 2012 Carbohydrate libraries printed in glycan micorarray format have had a great impact on the high-throughput analysis of the specificity of a wide range of mammalian, plant, and bacterial lectins. Chemical and chemo-enzymatic synthesis allows the construction of diverse glycan libraries but requires substantial effort and resources.
Christoph, Rademacher, James C, Paulson
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Analysis of the SARS-CoV-2 spike protein glycan shield reveals implications for immune recognition
Scientific Reports, 2020 Here we have generated 3D structures of glycoforms of the spike (S) glycoprotein from SARS-CoV-2, based on reported 3D structures and glycomics data for the protein produced in HEK293 cells.
Oliver C. Grant +3 more
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Glycans and Glycan-Binding Proteins as Regulators and Potential Targets in Leukocyte Recruitment
Frontiers in Cell and Developmental Biology, 2021 Leukocyte recruitment is a highly controlled cascade of interactions between proteins expressed by the endothelium and circulating leukocytes. The involvement of glycans and glycan-binding proteins in the leukocyte recruitment cascade has been well ...
Franziska Krautter, Asif J. Iqbal
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Virulence, 2022 Carbohydrates can both protect against infection and act as targets promoting infection. Mucins are major components of the slimy mucus layer covering the fish epithelia.
John Benktander +4 more
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Frontiers in Bioengineering and Biotechnology, 2022 Glycosylation is a critical quality attribute of monoclonal antibody (mAb) therapeutics. Hydrophilic interaction liquid chromatography-mass spectrometry (HILIC-MS) is an invaluable technology for the characterization of protein glycosylation.
Sumit K. Singh +2 more
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Inhibition of SARS-CoV-2 viral entry upon blocking N- and O-glycan elaboration
eLife, 2020 The Spike protein of SARS-CoV-2, its receptor-binding domain (RBD), and its primary receptor ACE2 are extensively glycosylated. The impact of this post-translational modification on viral entry is yet unestablished.
Qi Yang +8 more
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