Results 331 to 340 of about 145,105 (353)
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Biochimica et Biophysica Acta (BBA) - General Subjects, 2012
Non-invasive biomarkers, such as those from serum, are ideal for disease prognosis, staging and monitoring. In the past decade, our understanding of the importance of glycosylation changes with disease has evolved.We describe potential biomarkers derived from serum glycoproteins for liver, pancreatic, prostate, ovarian, breast, lung and stomach cancers.
Barbara Adamczyk +2 more
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Non-invasive biomarkers, such as those from serum, are ideal for disease prognosis, staging and monitoring. In the past decade, our understanding of the importance of glycosylation changes with disease has evolved.We describe potential biomarkers derived from serum glycoproteins for liver, pancreatic, prostate, ovarian, breast, lung and stomach cancers.
Barbara Adamczyk +2 more
openaire +3 more sources
Preparation of Glycan Arrays Using Pyridylaminated Glycans
2016We describe the method to prepare neoglycoproteins from the conjugation of bovine serum albumin and pyridylaminated glycans. Large quantities of glycans (>1 mg) can be pyridylaminated and then converted to their 1-amino-1-deoxy derivatives by reaction with hydrogen followed by hydrazine.
Shin-ichi Nakakita, Jun Hirabayashi
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Journal of Neuroscience Research, 2014
Human P0 is the main myelin glycoprotein of the peripheral nervous system. It can bind six different glycans, all linked to Asn93, the unique glycosylation site. Other myelin glycoproteins, also with a single glycosylation site (PMP22 at Asn36, MOG at Asn31), bind only one glycan.
Sedzik J +2 more
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Human P0 is the main myelin glycoprotein of the peripheral nervous system. It can bind six different glycans, all linked to Asn93, the unique glycosylation site. Other myelin glycoproteins, also with a single glycosylation site (PMP22 at Asn36, MOG at Asn31), bind only one glycan.
Sedzik J +2 more
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ACS Chemical Biology, 2013
Glycans participate in many key cellular processes during development and in physiology and disease. In this review, the functional role of various glycans in the regeneration of neurons and body parts in adult metazoans is discussed. Understanding glycosylation may facilitate research in the field of stem cell biology and regenerative medicine.
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Glycans participate in many key cellular processes during development and in physiology and disease. In this review, the functional role of various glycans in the regeneration of neurons and body parts in adult metazoans is discussed. Understanding glycosylation may facilitate research in the field of stem cell biology and regenerative medicine.
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2011
Glycan microarrays are presentations of multiple glycans or glycoconjugates printed on a single slide for screening with glycan-binding proteins (GBPs), which include lectins, antibodies, bacteria, and viruses. Glycans derivatized with functional groups can be immobilized onto appropriately activated glass slides to generate glycan microarrays where ...
Xuezheng, Song +3 more
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Glycan microarrays are presentations of multiple glycans or glycoconjugates printed on a single slide for screening with glycan-binding proteins (GBPs), which include lectins, antibodies, bacteria, and viruses. Glycans derivatized with functional groups can be immobilized onto appropriately activated glass slides to generate glycan microarrays where ...
Xuezheng, Song +3 more
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Expert Review of Proteomics, 2010
Glycan microarrays are emerging as increasingly used screening tools with a high potential for unraveling protein-carbohydrate interactions: probing hundreds or even thousands of glycans in parallel, they provide the researcher with a vast amount of data in a short time-frame, while using relatively small amounts of analytes. Natural glycan microarrays
Lonardi, E. +3 more
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Glycan microarrays are emerging as increasingly used screening tools with a high potential for unraveling protein-carbohydrate interactions: probing hundreds or even thousands of glycans in parallel, they provide the researcher with a vast amount of data in a short time-frame, while using relatively small amounts of analytes. Natural glycan microarrays
Lonardi, E. +3 more
openaire +4 more sources
2021
Glycosylation, one of the most common post-translational modifications in mammalian cells, impacts many biological processes such as cell adhesion, proliferation and differentiation. As the most abundant glycoprotein in human serum, immunoglobulin G (IgG) plays a vital role in immune response and protection. There is a growing body of evidence suggests
Xin Liu, Si Liu
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Glycosylation, one of the most common post-translational modifications in mammalian cells, impacts many biological processes such as cell adhesion, proliferation and differentiation. As the most abundant glycoprotein in human serum, immunoglobulin G (IgG) plays a vital role in immune response and protection. There is a growing body of evidence suggests
Xin Liu, Si Liu
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Journal of Mathematical Biology, 2013
We present an algorithm for counting glycan topologies of order n that improves on previously described algorithms by a factor n in both time and space. More generally, we provide such an algorithm for counting rooted or unrooted d-ary trees with labels or masses assigned to the vertices, and we give a "recipe" to estimate the asymptotic growth of the ...
Sebastian Böcker, Stephan Wagner
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We present an algorithm for counting glycan topologies of order n that improves on previously described algorithms by a factor n in both time and space. More generally, we provide such an algorithm for counting rooted or unrooted d-ary trees with labels or masses assigned to the vertices, and we give a "recipe" to estimate the asymptotic growth of the ...
Sebastian Böcker, Stephan Wagner
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Norovirus, glycans and attachment
Current Opinion in Virology, 2018Noroviruses engage glycans as essential attachment factors to promote infection of host cells. The past decade has witnessed significant progress in the field of norovirus research. Cell culture systems and animal models have become available, and structural biology and biophysics have significantly expanded our understanding of norovirus–glycan ...
Thomas Peters +2 more
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1997
The initial steps in the biosynthesis of N-glycans have been are preserved throughout evolution and are similar in lower and higher species. In contrast to O-glycans, N-glycans are pre-assembled as a dolicholpyrophosphate-(Dol-P-P-) intermediate and then transferred to protein by the action of oligosaccharyltransferase in the ER.
William Kuhns, Inka Brockhausen
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The initial steps in the biosynthesis of N-glycans have been are preserved throughout evolution and are similar in lower and higher species. In contrast to O-glycans, N-glycans are pre-assembled as a dolicholpyrophosphate-(Dol-P-P-) intermediate and then transferred to protein by the action of oligosaccharyltransferase in the ER.
William Kuhns, Inka Brockhausen
openaire +3 more sources