Results 31 to 40 of about 144,829 (355)

Discovery of Highly Active Recombinant PNGase H+ Variants Through the Rational Exploration of Unstudied Acidobacterial Genomes

Frontiers in Bioengineering and Biotechnology, 2020
Peptide-N4-(N-acetyl-β-glucosaminyl) asparagine amidases (PNGases, N-glycanases, EC 3.5.1.52) are indispensable tools in releasing N-glycans from glycoproteins.
Rui-Rui Guo, Gerard Comamala, Huan-Huan Yang, Marius Gramlich, Ya-Min Du, Ting Wang, Anne Zeck, Kasper Dyrberg Rand, Li Liu, Josef Voglmeir   +9 more
doaj   +1 more source

Rationally designed immunogens enable immune focusing following SARS-CoV-2 spike imprinting

Cell Reports, 2022
Summary: Eliciting antibodies to surface-exposed viral glycoproteins can generate protective responses that control and prevent future infections. Targeting conserved sites may reduce the likelihood of viral escape and limit the spread of related viruses
Blake M. Hauser, Maya Sangesland, Kerri J. St. Denis, Evan C. Lam, James Brett Case, Ian W. Windsor, Jared Feldman, Timothy M. Caradonna, Ty Kannegieter, Michael S. Diamond, Alejandro B. Balazs, Daniel Lingwood, Aaron G. Schmidt   +12 more
doaj   +1 more source

Carrier-Free Immobilization of Rutin Degrading Enzyme Extracted From Fusarium spp.

Frontiers in Bioengineering and Biotechnology, 2020
In this study, a strain with rutin degrading enzyme (RDE) activity was screened from moldy tartary buckwheat and subsequently identified as Fusarium spp. The structure and enzyme characteristics of CLEA-RDE formed by immobilization via cross-linking were
Yuan-Yuan Zang, Sha Yang, Yong-Qiang Xu, Zhi-Gang Chen, Tao Wu   +4 more
doaj   +1 more source

Synthesis and glycosidation of building blocks of D-altrosamine

Frontiers in Chemistry, 2022
Presented herein is a streamlined synthesis of building blocks of a rare sugar D-altrosamine. Also investigated was the glycosylation of different glycosyl acceptors with differentially protected altrosamine donors.
Mariya Novakova, Anupama Das, Catherine Alex, Alexei V. Demchenko, Alexei V. Demchenko   +4 more
doaj   +1 more source

Understanding Snail Mucus Biosynthesis and Shell Biomineralisation through Genomic Data Mining of the Reconstructed Carbohydrate and Glycan Metabolic Pathways of the Giant African Snail (Achatina fulica)

Biology, 2023
The giant African snail (Order Stylommatophora: Family Achatinidae), Achatina fulica (Bowdich, 1822), is the most significant and invasive land snail pest.
Pornpavee Nualnisachol, Pramote Chumnanpuen, Teerasak E-kobon   +2 more
doaj   +1 more source

Are glycan biosensors an alternative to glycan microarrays? [PDF]

Anal. Methods, 2014
Complex carbohydrates (glycans) play an important role in nature and study of their interaction with proteins or intact cells can be useful for understanding many physiological and pathological processes.
A. Hushegyi, J. Tkac
openaire   +2 more sources

Influenza Neuraminidase Inhibitors: Synthetic Approaches, Derivatives and Biological Activity

Molecules, 2016
Despite being a common viral disease, influenza has very negative consequences, causing the death of around half a million people each year. A neuraminidase located on the surface of the virus plays an important role in viral reproduction by contributing
Pedro Laborda, Su-Yan Wang, Josef Voglmeir   +2 more
doaj   +1 more source

Glyco-Engineering Plants to Produce Helminth Glycoproteins as Prospective Biopharmaceuticals: Recent Advances, Challenges and Future Prospects

Frontiers in Plant Science, 2022
Glycoproteins are the dominant category among approved biopharmaceuticals, indicating their importance as therapeutic proteins. Glycoproteins are decorated with carbohydrate structures (or glycans) in a process called glycosylation.
Alex van der Kaaij, Kim van Noort, Pieter Nibbering, Ruud H. P. Wilbers, Arjen Schots   +4 more
doaj   +1 more source

Enzymatic Synthesis of Trideuterated Sialosides

Molecules, 2019
Sialic acids are a family of acidic monosaccharides often found on the termini of cell surface proteins or lipid glycoconjugates of higher animals. Herein we describe the enzymatic synthesis of the two isotopically labeled sialic acid derivatives d3-X ...
Zhi-P. Cai, Louis P. Conway, Ying Y. Huang, Wen J. Wang, Pedro Laborda, Ting Wang, Ai M. Lu, Hong L. Yao, Kun Huang, Sabine L. Flitsch, Li Liu, Josef Voglmeir   +11 more
doaj   +1 more source

An Efficient and Economical N-Glycome Sample Preparation Using Acetone Precipitation

Metabolites, 2022
Due to the critical role of the glycome in organisms and its close connections with various diseases, much time and effort have been dedicated to glycomics-related studies in the past decade.
Junyao Wang, Wenjing Peng, Mojibola Fowowe, Oluwatosin Daramola, Yehia Mechref   +4 more
doaj   +1 more source