Results 41 to 50 of about 144,829 (355)
CHARMM-GUI Glycan Modeler for modeling and simulation of carbohydrates and glycoconjugates
Glycobiology, 2019 Characterizing glycans and glycoconjugates in the context of three-dimensional structures is important in understanding their biological roles and developing efficient therapeutic agents.
Sang-Jun Park +9 more
semanticscholar +1 more source
Site-specific analysis of the SARS-CoV-2 glycan shield
bioRxiv, 2020 The emergence of the betacoronavirus, SARS-CoV-2 that causes COVID-19, represents a significant threat to global human health. Vaccine development is focused on the principal target of the humoral immune response, the spike (S) glycoprotein, that ...
Yasunori Watanabe +4 more
semanticscholar +1 more source
Fluorescent Glycan Derivatives: Their Use for Natural Glycan Microarrays [PDF]
ACS Chemical Biology, 2009 Glycan microarrays have become powerful tools in the investigation of biological systems because they enable fast, quantitative, and simultaneous analysis of glycan-protein interactions with small quantities of samples. One hurdle in the construction of glycan microarrays is to obtain a diverse set of glycans for immobilization on surfaces.
Sungjin, Park +2 more
openaire +2 more sources
Sensors, 2023 Protein–carbohydrate interactions happen to be a crucial facet of biology, discharging a myriad of functions. Microarrays have become a premier choice to discern the selectivity, sensitivity and breadth of these interactions in a high-throughput manner ...
Paras H. Kundalia +5 more
doaj +1 more source
Investigating virus–glycan interactions using glycan microarrays [PDF]
Current Opinion in Virology, 2014 While all viruses must transit the plasma membrane of mammalian cells to initiate infection, we know little about the complex processes involved in viral attachment, which commonly involve recognition of glycans by viral proteins. Glycan microarrays derived from both synthetic glycans and natural glycans isolated through shotgun glycomics approaches ...
David F, Smith, Richard D, Cummings
openaire +2 more sources
Computational tools for drawing, building and displaying carbohydrates: a visual guide
Beilstein Journal of Organic Chemistry, 2020 Drawing and visualisation of molecular structures are some of the most common tasks carried out in structural glycobiology, typically using various software.
Kanhaya Lal, Rafael Bermeo, Serge Perez
doaj +1 more source
Frontiers in Immunology, 2018 IgG antibodies (Abs) mediate their effector functions through the interaction with Fcγ receptors (FcγRs) and the complement factors. The main IgG-mediated complement activation pathway is induced through the binding of complement C1q to IgG Abs.
Gina-Maria Lilienthal +7 more
doaj +1 more source
Mucin glycan foraging in the human gut microbiome
Frontiers in Genetics, 2015 The availability of host and dietary carbohydrates in the gastrointestinal (GI) tract plays a key role in shaping the structure-function of the microbiota. In particular, some gut bacteria have the ability to forage on glycans provided by the mucus layer
L. Tailford +3 more
semanticscholar +1 more source
Communal Living: Glycan Utilization by the Human Gut Microbiota.
Environmental Microbiology, 2020 Our lower gastrointestinal tract plays host to a vast consortium of microbes, known as the Human Gut Microbiota (HGM). The HGM thrives on a complex and diverse range of glycan structures from both dietary and host sources, the breakdown of which requires
Jonathon A. Briggs +2 more
semanticscholar +1 more source
The Analyst, 2020 Retention time normalization of permethylated glycans and glycan isomers across different instruments and laboratories, using standard dextrin ladder. (Figure created with BioRender.com).
Sakshi Gautam +7 more
openaire +3 more sources