Salmonella Degrades the Host Glycocalyx Leading to Altered Infection and Glycan Remodeling. [PDF]
, 2016 Complex glycans cover the gut epithelial surface to protect the cell from the environment. Invasive pathogens must breach the glycan layer before initiating infection.
Arabyan, Narine +11 more
core +1 more source
Carrier-Free Immobilization of Rutin Degrading Enzyme Extracted From Fusarium spp.
Frontiers in Bioengineering and Biotechnology, 2020 In this study, a strain with rutin degrading enzyme (RDE) activity was screened from moldy tartary buckwheat and subsequently identified as Fusarium spp. The structure and enzyme characteristics of CLEA-RDE formed by immobilization via cross-linking were
Yuan-Yuan Zang +4 more
doaj +1 more source
Virulence, 2022 Carbohydrates can both protect against infection and act as targets promoting infection. Mucins are major components of the slimy mucus layer covering the fish epithelia.
John Benktander +4 more
doaj +1 more source
MedChemComm, 2019 Exploiting glycan recognition in drug discovery.
Ana Ardá +5 more
openaire +4 more sources
Enzymatic Synthesis of Trideuterated Sialosides
Molecules, 2019 Sialic acids are a family of acidic monosaccharides often found on the termini of cell surface proteins or lipid glycoconjugates of higher animals. Herein we describe the enzymatic synthesis of the two isotopically labeled sialic acid derivatives d3-X ...
Zhi-P. Cai +11 more
doaj +1 more source
Glycans and Glycan-Binding Proteins as Regulators and Potential Targets in Leukocyte Recruitment
Frontiers in Cell and Developmental Biology, 2021 Leukocyte recruitment is a highly controlled cascade of interactions between proteins expressed by the endothelium and circulating leukocytes. The involvement of glycans and glycan-binding proteins in the leukocyte recruitment cascade has been well ...
Franziska Krautter, Asif J. Iqbal
doaj +1 more source
From structural to functional glycomics: core substitutions as molecular switches for shape and lectin affinity of N-glycans [PDF]
, 2009 Glycan epitopes of cellular glycoconjugates act as versatile biochemical signals (sugar coding). Here, we test the hypothesis that the common N-glycan modifications by core fucosylation and introduction of the bisecting N-acetylglucosamine moiety have ...
André, Sabine +4 more
core +1 more source
Human T cell glycosylation and implications on immune therapy for cancer [PDF]
, 2020 Glycosylation is an important post-translational modification, giving rise to a diverse and abundant repertoire of glycans on the cell surface, collectively known as the glycome.
Callewaert, Nico +3 more
core +1 more source
Site-specific analysis of the SARS-CoV-2 glycan shield
bioRxiv, 2020 The emergence of the betacoronavirus, SARS-CoV-2 that causes COVID-19, represents a significant threat to global human health. Vaccine development is focused on the principal target of the humoral immune response, the spike (S) glycoprotein, that ...
Yasunori Watanabe +4 more
semanticscholar +1 more source
A combined computational-experimental approach to define the structural origin of antibody recognition of sialyl-Tn, a tumor-associated carbohydrate antigen. [PDF]
, 2018 Anti-carbohydrate monoclonal antibodies (mAbs) hold great promise as cancer therapeutics and diagnostics. However, their specificity can be mixed, and detailed characterization is problematic, because antibody-glycan complexes are challenging to ...
Amon, Ron +12 more
core +2 more sources