Results 61 to 70 of about 181,761 (403)
First Step Towards Glycan Modeling: Charmm-Gui Glycan Reader and Glycan Database [PDF]
Biophysical Journal, 2011 Glycosylation is an important post-translational modification of proteins. Considerable efforts have been made to understand how glycosylation affects the structure, dynamics and function of proteins, yet, in general terms, it remains an unsolved questions due to the diversity and variability in the glycosylation.
Alexander D. MacKerell +3 more
openaire +2 more sources
Symbiotic Human Gut Bacteria with Variable Metabolic Priorities for Host Mucosal Glycans. [PDF]
, 2015 UnlabelledMany symbiotic gut bacteria possess the ability to degrade multiple polysaccharides, thereby providing nutritional advantages to their hosts.
German, J Bruce +5 more
core +2 more sources
Mucin glycan foraging in the human gut microbiome
Frontiers in Genetics, 2015 The availability of host and dietary carbohydrates in the gastrointestinal (GI) tract plays a key role in shaping the structure-function of the microbiota. In particular, some gut bacteria have the ability to forage on glycans provided by the mucus layer
L. Tailford +3 more
semanticscholar +1 more source
Histo-blood group glycans in the context of personalized medicine [PDF]
Biochimica et Biophysica Acta 1860 (2016) 1596-1607, 2019 Background: A subset of histo-blood group antigens including ABO and Lewis are oligosaccharide structures which may be conjugated to lipids or proteins. They are known to be important recognition motifs not only in the context of blood transfusions, but also in infection and cancer development.
arxiv +1 more source
Cellular O-Glycome Reporter/Amplification to explore O-glycans of living cells [PDF]
, 2015 Protein O-glycosylation has key roles in many biological processes, but the repertoire of O-glycans synthesized by cells is difficult to determine. Here we describe an approach termed Cellular O-Glycome Reporter/Amplification (CORA), a sensitive method ...
Antonopoulos, A +9 more
core +1 more source
Communal Living: Glycan Utilization by the Human Gut Microbiota.
Environmental Microbiology, 2020 Our lower gastrointestinal tract plays host to a vast consortium of microbes, known as the Human Gut Microbiota (HGM). The HGM thrives on a complex and diverse range of glycan structures from both dietary and host sources, the breakdown of which requires
Jonathon A. Briggs +2 more
semanticscholar +1 more source
Nature, 2020 Imaging of biomolecules guides our understanding of their diverse structures and functions1,2. Real-space imaging at sub-nanometre resolution using cryo-electron microscopy has provided key insights into proteins and their assemblies3,4. Direct molecular imaging of glycans-the predominant biopolymers on Earth, with a plethora of structural and ...
Uta Schlickum +16 more
openaire +3 more sources
Characterization of Cell Glycocalyx with Mass Spectrometry Methods. [PDF]
, 2019 The cell membrane plays an important role in protecting the cell from its extracellular environment. As such, extensive work has been devoted to studying its structure and function.
Lebrilla, Carlito B +3 more
core +2 more sources
Protein glycosylation as a diagnostic and prognostic marker of chronic inflammatory gastrointestinal and liver diseases [PDF]
, 2020 Glycans are sequences of carbohydrates that are added to proteins or lipids to modulate their structure and function. Glycans modify proteins required for regulation of immune cells, and alterations have been associated with inflammatory conditions.
Callewaert, Nico +6 more
core +1 more source
Frontiers in Immunology, 2018 IgG antibodies (Abs) mediate their effector functions through the interaction with Fcγ receptors (FcγRs) and the complement factors. The main IgG-mediated complement activation pathway is induced through the binding of complement C1q to IgG Abs.
Gina-Maria Lilienthal +7 more
doaj +1 more source