Results 81 to 90 of about 144,829 (355)

The DyP-type peroxidase DtpA is a Tat-substrate required for GlxA maturation and morphogenesis in Streptomyces [PDF]

Open Biology, 2016
The filamentous bacterium Streptomyces lividans depends on the radical copper oxidase GlxA for the formation of reproductive aerial structures and, in liquid environments, for the formation of pellets.
Marloes L. C. Petrus, Erik Vijgenboom, Amanda K. Chaplin, Jonathan A. R. Worrall, Gilles P. van Wezel, Dennis Claessen   +5 more
doaj   +1 more source

Bisecting GlcNAc Is a General Suppressor of Terminal Modification of N-glycan*

Molecular & Cellular Proteomics, 2019
Bisecting GlcNAc, a branching sugar in N-glycan highly expressed in brain, is involved in Alzheimer's disease, but its physiological function is largely unclear.
M. Nakano, S. Mishra, Y. Tokoro, Keiko Sato, K. Nakajima, Y. Yamaguchi, N. Taniguchi, Yasuhiko Kizuka   +7 more
semanticscholar   +1 more source

Mesenchymal Stem Cell‐Derived Apoptotic Micro‐Vesicles Repaired Sciatic Nerve Defect by Regulating Early Inflammatory Microenvironment and Promoting Angiogenesis

Advanced Healthcare Materials, EarlyView.
HUCMSC‐Apo‐mvs enhance peripheral nerve repair by modulating the inflammatory microenvironment (IME), primarily through coordinated actions on three functional cells. They recruit macrophages and promote their polarization from pro‐inflammatory M1 to anti‐inflammatory M2 phenotypes, increasing secretion of IL‐10 and VEGF.
Haolin Liu, Yiben Ouyang, Bo Wang, Xiaochun Zhang, Yanjun Guan, Ruichao He, Yuhui Cui, Junli Wang, Qianru Yao, Yixiao Tan, Xiwei Peng, Xing Xiong, Sice Wang, Dongdong Li, Haofeng Cheng, Tianqi Su, Xiaoyang Fu, Jinjuan Zhao, Mingqian Yu, Yi Wang, Jiang Peng, Yu Wang   +21 more
wiley   +1 more source

Glycan Nanostructures of Human Coronaviruses

International Journal of Nanomedicine, 2021
Wanru Guo,1 Harini Lakshminarayanan,2 Alex Rodriguez-Palacios,3– 6 Robert A Salata,7 Kaijin Xu,1 Mohamed S Draz7 1State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases ...
Guo W, Lakshminarayanan H, Rodriguez-Palacios A, Salata RA, Xu K, Draz MS   +5 more
doaj  

Routing Nanomolar Protein Cargoes to Lipid Raft‐Mediated/Caveolar Endocytosis through a Ganglioside GM1‐Specific Recognition Tag

Advanced Science, 2020
There is a pressing need to develop ways to deliver therapeutic macromolecules to their intracellular targets. Certain viral and bacterial proteins are readily internalized in functional form through lipid raft‐mediated/caveolar endocytosis, but ...
Norbert Imre, Anasztázia Hetényi, Enikő Szabó, Brigitta Bodnár, Abel Szkalisity, Ilona Gróf, Alexandra Bocsik, Mária A. Deli, Peter Horvath, Ágnes Czibula, Éva Monostori, Tamás A. Martinek   +11 more
doaj   +1 more source

Glycan‐Mediated Grafting of Extracellular Matrix Proteins for Stable Biofunctionalization of Polystyrene Surfaces

Advanced Materials Interfaces, EarlyView.
We present a glycan‐mediated strategy for covalent grafting of extracellular matrix proteins onto polystyrene surfaces. This approach preserves protein bioactivity and enhances cell adhesion and viability. Using fibronectin and vitronectin, we demonstrate stable immobilization via glycosylation sites, offering a promising route for advanced ...
Mathilde Hindié, Damien Seyer, Ousmane Ba, Anthony C. Duncan, Arnaud Ponche, Olivier Gallet, Karine Anselme   +6 more
wiley   +1 more source

Human Influenza A Virus Hemagglutinin Glycan Evolution Follows a Temporal Pattern to a Glycan Limit

mBio, 2019
Frequent mutation of its major antibody target, the glycoprotein hemagglutinin, ensures that the influenza virus is perennially both a rapidly emerging virus and a major threat to public health.
Meghan O. Altman, M. Angel, Ivan Košík, N. S. Trovão, Seth J. Zost, J. Gibbs, L. Casalino, Rommie E. Amaro, S. Hensley, M. Nelson, J. Yewdell   +10 more
semanticscholar   +1 more source

The glycans of stem cells [PDF]

Current Opinion in Chemical Biology, 2007
Glycans cover all cellular surfaces and, not surprisingly, are involved in many facets of stem cell biology and technology. For instance, coaxing stem cells to either proliferate or differentiate into the specific cell types needed for transplantation requires intricate glycan-dependent modulation of signalling molecules such as FGF-2, Wnt, and Notch ...
Pascal M, Lanctot, Fred H, Gage, Ajit P, Varki   +2 more
openaire   +2 more sources

T Cell Glycoengineering to Modulate Immune‐Tumor Crosstalk: A Universal Non‐Genetic Strategy for Enhanced Tumor Immunotherapy

Advanced Science, EarlyView.
This study describes a T cell surface engineering strategy that integrates polymer materials with tumor immunology, aiming to achieve broad‐spectrum anti‐tumor applications of glycopolymer‐engineered T (G‐T) cells via non‐genetic modification. Glycopolymer engineering generally modulates immune‐tumor crosstalk through specific cell‐cell interactions ...
Lihua Yao, He Yang, Fangjian Shan, Xiaomeng Niu, Yichen Wang, Hengyuan Zhang, Sujian Wang, Gaojian Chen, Hong Chen   +8 more
wiley   +1 more source

The glycans of soybean peroxidase [PDF]

Glycobiology, 1996
Soybean hull peroxidase (SBP, E.C. 1.11.1.7), an anionic glycoprotein, was found to contain 18.2% carbohydrate with the average composition: 2 mol GlcNAc, 3.3 mol Man, 0.9 mol Fuc, and 0.7 mol Xyl. The oligosaccharides of SBP, after release with glycopeptidase A, were investigated by a combination of high pH anion exchange chromatography with pulsed ...
J S, Gray, B Y, Yang, S R, Hull, D P, Venzke, R, Montgomery   +4 more
openaire   +2 more sources