Results 171 to 180 of about 88,542 (309)

Glycopolymeric nanoparticles transported by activated platelets protect ischemic myocardium by alleviating PANoptosis through targeting macrophage Dectin‐1

BMEMat, EarlyView.
NP‐SF, designed to target macrophage Dectin‐1 and activated platelets, selectively accumulated in ischemic myocardium, where it was taken up by macrophages after platelet hitchhiking. By inhibiting NLRC5‐related PANoptosis, NP‐SF significantly attenuated pathological damage, and effectively preserved cardiac function in a murine ischemia–reperfusion ...
Guanye Yu, Na Yang, Yan Zhang, Lingxin Peng, Yi Li, Yue Chao, Qinfang Miao, Haikun Qi, Jianhui Zhuang, Weixia Jian, Bingyu Li, Wenhui Peng, Jinghua Chen, Shiyu Gong   +13 more
wiley   +1 more source

Site-specific O-glycans influence lacritin structure and multimerization in tears. [PDF]

Protein Sci
Chang V, Chen RJ, Lian I, Hamilton M, Mahoney KE, Romano J, Laurie G, Malaker SA.   +7 more
europepmc   +1 more source

Bridging the translational gap in clinical nanomedicine: From rational design to clinical reality

BMEMat, EarlyView.
Nanotechnology offers a multi‐faceted approach to modern healthcare, encompassing high‐sensitivity diagnostic imaging, innovative vaccine delivery, and targeted therapeutics. This review explores how these nanomedicine applications address critical challenges in cancer recurrence and the treatment of neurologic and respiratory diseases to combat rising
Ahmed H. Ghonaim, Marwa Ahmed El‐Naka, Wedad M. Nageeb, Atta Ullah Khan, Noura M. Seleem, Aliaa Abdelghafar, Doaa Zamel, Yang Liu, Qigai He, Wentao Li   +9 more
wiley   +1 more source

Chemical inhibition of α-mannosidase in <i>S. mansoni</i> schistosomula leads to reshaped N-glycosylation associated with developmental alterations. [PDF]

Front Parasitol
Kuhlemaijer EB, Veldhuizen T, Hoekstra QCA, Umbach JA, Niezen MJ, Forde-Thomas JE, Rinaldi G, Hoffmann KF, van Diepen A, Hokke CH.   +9 more
europepmc   +1 more source

Regenerative perfusion bioreactor for biologics production with lower COGs

Biotechnology Progress, EarlyView.
Abstract Perfusion bioreactor systems enable intensified bioprocessing with high cell densities and volumetric productivities in monoclonal antibody (mAb) manufacturing. However, their widespread adoption remains constrained by the high consumption of chemically defined cell culture media.
Eric Wynne, Dohyun Park, Hourieh Ahi, Jaeweon Lee, Seongkyu Yoon, Jongyoon Han   +5 more
wiley   +1 more source

Plant Molecular Farming for Cancer Immunotherapy: Production, Glycoengineering, and Structural Insights into Therapeutic Monoclonal Antibodies. [PDF]

Curr Issues Mol Biol
Tamayo-Ordoñez MC, García-Castillo MJ, Tamayo-Ordoñez FA, Suárez-Valencia VJ, Córdova-Quiroz AV, Ramos-García VH, Ayil-Gutiérrez BA, Domínguez-May AV, Nahuat-Dzib SL, Robles-Heredia JC, Lizama-Gasca MG, Lozano-Venegas D, Velasco-Rodríguez VM, Cazares-Sánchez E, Díaz-Palafox G, Tamayo-Ordoñez YJ.   +15 more
europepmc   +1 more source

Multivalent RNA‐Cleaving Agents on a Cubic Octameric Silsesquioxane Core

Chemistry – A European Journal, EarlyView.
RNA‐cleaving agents on a cubic octameric silsesquioxane core were synthesized and characterized. Several catalytic systems of these structures were screened using hexaribonucleotide models. The best systems were then further used to study their catalytic efficiency in cleaving a HER2 mRNA model sequence. The induced cleavage sites were also determined.
Hanni Haapsaari, Iris Tuomi, Pasi Virta
wiley   +1 more source

Immobilised enzyme reactors for post-production glycan modification of purified glycoproteins. [PDF]

Front Mol Biosci
DeBono NJ, Cain J, Lin CH, Packer NH, Moh ESX.   +4 more
europepmc   +1 more source

MurNAc‐Based Electrophilic Inhibitors of O‐Acetylpeptidoglycan Esterase (Ape): Design, Synthesis, and Kinetic Evaluation

Chemistry – A European Journal, EarlyView.
A series of N‐acetylmuramic acid (MurNAc)‐based electrophilic inhibitors targeting Ape esterase was synthesized. Their inhibitory potency ranged from micromolar to submillimolar. The study probed binding contributions of stem peptide extension, replacing the anomeric methyl group with a benzyl, and α‐fluorination of the carbonyl to enhance ...
Dmytro Voskoboinyk, Martin E. Tanner
wiley   +1 more source

Glycosylation Heterogeneity of α1-Acid Glycoprotein: Disease-Associated Glycoform Remodeling, Regulatory Mechanisms, and Clinical Translation. [PDF]

Biomolecules
Liu G, Fan N, Wang Y, Dong W.
europepmc   +1 more source