Results 201 to 210 of about 88,542 (309)

Gut microbiota dysbiosis‐mediated gut NLRP3 inflammasome activation exacerbates corticospinal tract injury after intracerebral hemorrhage

Interdisciplinary Medicine, EarlyView.
Schematic depicting a gut‐brain pathway that exacerbates CST injury after ICH. Gut Microbiota Dysbiosis‐Mediated Gut NLRP3 Inflammasome Activation Exacerbates Corticospinal Tract Injury After Intracerebral Hemorrhage. Abstract Intracerebral hemorrhage (ICH) causes severe neurological deficits largely attributable to corticospinal tract (CST) injury ...
Meiqin Zeng, Meichang Peng, Chen He, Yanmeng Zhao, Zizhang Cheng, Mengchen Yu, Hao Tian, Lu Zhang, Wen Yuan, Qing Zeng, Jiandong Huang, Haitao Sun   +11 more
wiley   +1 more source

A Common Small-Molecule Inhibitor Targeting Multiple Siglecs Associated with Immune Checkpoint Suppression of Cytotoxicity and Phagocytosis. [PDF]

J Am Chem Soc
Chung C, Li R, Cheng LC, Fan CY, Liao KS, Kung CC, Wong CH.   +6 more
europepmc   +1 more source

Glycan biomaker in CSF

Rinsho Shinkeigaku, 2010
Hashimoto, Yasuhiro, Futakawa, Satoshi, Miyajima, Masakazu, Kitazume, Shinobu, Nara, Kiyomitsu, Shirotani, Keiro, Kuno, Atsushi, Ito, Hiromi, Honda, Takashi, Furukawa, Katsutoshi, Tasaki, Kazuhiro, Arai, Hiroyuki, Yuasa, Tatsuhiko, Abe, Masafumi, Narimatsu, Hisashi, Arai, Hajime   +15 more
openaire   +3 more sources

Specific peptide enrichment strategies for neuropsychiatric disorders: From material design to diagnostic applications

Interdisciplinary Medicine, EarlyView.
This review outlines specific peptide enrichment strategies, including metal, magnetic oxides, functional polymers, and antibody‐based approaches, and their mechanisms, highlighting applications in biomarker discovery for major neurological and psychiatric disorders.
Xue Zhang, Yejiao Shi, Minghui Guo, Yang Huang, Yirong Wang, Leping Huang, Helena S. Azevedo, Honggang Hu, Xin Dong   +8 more
wiley   +1 more source

Longitudinal Changes in IgG N-glycome Are Associated with Disease Severity and Mortality in COVID-19 Patients. [PDF]

Viruses
Vinicki M, Vučković F, Bodulić K, Markotić A, Barušić Z, Laškaj R, Kurolt IC, Zember S, Čivljak R, Puljiz I, Lauc G, Pribić T.   +11 more
europepmc   +1 more source

Ion Activation Methods for Top‐Down Proteomics

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Mass spectrometry (MS) has emerged as a premier method used to characterize the sequences of proteins. Top‐down proteomics aims to capture the multiple sources of structural diversity reflected in proteins, such as those that arise from alternative RNA splicing events or the addition of post‐translational modifications. Tandem MS (i.e., MS/MS)
Jada N. Walker, Jennifer S. Brodbelt
wiley   +1 more source

Single-monosaccharide resolution glycan profiling enabled by the nanopipette. [PDF]

Chem Sci
Ma H, Li YX, Xu Z, Ma W, Xia B, Gao Z, Li T, Ying YL.   +7 more
europepmc   +1 more source

Recent Advances (2023–2025) of Capillary Electrophoresis‐Mass Spectrometry (CE‐MS) for Top‐Down Proteomics

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Top‐down proteomics (TDP) characterizes proteoforms in cells, tissues, and biofluids, in discovery mode and on a global scale, requiring analytical tools with high peak capacity for proteoform separation and high sensitivity for proteoform detection, given the extremely high proteoform complexity and wide proteoform concentration dynamic range.
Guijie Zhu, David A. Alvarez Rodriguez, Noah Gould, Alexander R. Ivanov, Kevin Jooß, Liangliang Sun   +5 more
wiley   +1 more source

Targeting glycans for cancer immunotherapy. [PDF]

Nat Biotechnol
europepmc   +1 more source