Results 271 to 280 of about 130,285 (343)

Cardiovascular Disease Meets Cancer: Exploring the Epidemiology in China and Homotherapy Targeting Intersectional Mechanisms

Advanced Science, Volume 12, Issue 37, October 6, 2025.
Cardiovascular disease (CVD) and cancer are leading causes of death worldwide, with overlapping risk factors and pathophysiological mechanisms. This review explores shared pathways, including metabolic dysregulation, chronic inflammation, and gut microbiome alterations, highlighting dual‐benefit strategies such as lifestyle modifications and repurposed
Shihan Xiang, Yujie Shan, Shihong Xu, Jing Wang, Meng Luo, Jiaojiao Zhou, Qishan Chen   +6 more
wiley   +1 more source

<i>Khaya grandifololia</i> exerts multitarget neuroprotective potential against neurodegenerative disorders: <i>In vitro</i> and <i>in silico</i> studies. [PDF]

IBRO Neurosci Rep
Ella FA, Ambamba BDA, Njayou FN, Moundipa PF.   +3 more
europepmc   +1 more source

Association between glycated haemoglobin A1c and total haemoglobin mass in adults with type 1 diabetes mellitus. A proof‐of‐concept study

Diabetes, Obesity and Metabolism, Volume 27, Issue 11, Page 6737-6742, November 2025.
Janis Schierbauer, Sabrina Sanfilippo, Nadine Wachsmuth, Othmar Moser   +3 more
wiley   +1 more source

Epigenetic Regulation of DAPK1 and Netrin‐1 Drives Diabetic Encephalopathy

Advanced Science, Volume 12, Issue 37, October 6, 2025.
This study identifies a microRNA (miR)‐216a‐5p/death‐associated protein kinase 1 (DAPK1)/hepatocyte nuclear factor 1 homeobox A (HNF1A)/Netrin‐1 signaling axis in diabetic encephalopathy (DE). In leptin receptor‐deficient (db/db) and streptozotocin (STZ)‐induced diabetic mice, reduced miR‐216a‐5p increases DAPK1 expression, disrupting HNF1A binding to ...
Yang Zhou, Jia‐Xin Kou, Kai Zheng, Zi‐Xuan Guo, Hong‐Wei Fan, Wen‐Lian Li, Lu‐Lu Chu, Jing‐Wen Yin, Li‐Jie Liu, Nadezhda Brazhe, Zhi‐Gao Xiang, Feng Hu, Kai Shu, Ling‐Qiang Zhu, Dan Liu   +14 more
wiley   +1 more source

Synthesis of promising brominated flavonoids as antidiabetic and anti-glycation agents. [PDF]

Sci Rep
Hairani R, Chavasiri W.
europepmc   +1 more source

Tunneling Nanotube‐Mediated Transcellular Autophagy Alleviates Cadmium Induced Hepatocyte Injury

Advanced Science, Volume 12, Issue 37, October 6, 2025.
ROS accumulation is an important upstream signal for activating transcellular autophagy. Incomplete autophagy and TNT formation are necessary conditions for activating transcellular autophagy, and the disruption of the autophagic fusion mechanism is a trigger for activating transcellular autophagy.
Tao Wang, Li Wang, Jian Sun, Yan Chen, Waseem Ali, Yonggang Ma, Ruilong Song, Xishuai Tong, Jiaqiao Zhu, Yan Yuan, Jianhong Gu, Jianchun Bian, Zongping Liu, Hui Zou   +13 more
wiley   +1 more source

Advanced glycation end-product receptor gene (RAGE) polymorphisms in patients with acute coronary syndrome - a case-control study in the Polish population. [PDF]

BMC Med Genomics
Gutowska K, Ambroziak M, Podraza J, Puzianowska-Kuźnicka M, Czajkowski K, Budaj A, Kuryłowicz A.   +6 more
europepmc   +1 more source

Selective Increase in Decorin Core mRNA Level in Cultured Vascular Smooth Muscle Cells after Exposure to Advanced Glycation End products.

, 2000
Toshiyuki Kaji, Sawako Miyajima, Chika Yamamoto, Yasuyuki Fujiwara, Shigeru Sakurai, Sho Ichi Yamagishi, Katsuo Sueishi, Hiroshi Yamamoto   +7 more
openalex   +2 more sources

The Multitarget Compound ZLY032 Achieves Treatment of Chronic Wounds

Advanced Science, Volume 12, Issue 37, October 6, 2025.
ZLY032, a dual free fatty acid receptor 1/peroxisome proliferator‐activated receptor δ agonist, accelerates wound healing in normal/diabetic/methicillin‐resistant Staphylococcus aureus‐infected models by promoting angiogenesis, reducing inflammation, and exhibiting antibacterial activity via argininosuccinate lyase targeting, with demonstrated efficacy
Manyu Gong, Zhiyuan Du, Tiantian Gong, Yu Wang, Chenchen Yin, Bosi Sun, Zijia Liu, Lianru Chen, Zibin Liao, Wenxin Wang, Tianjiao Zhao, Yifei Wang, Ying Dong, Kexin Wang, Mengru Ma, Weijun Li, Jiacheng Li, Haodong Li, Congcong Lin, Ying Zhang, Yu Liu, Xin Liu, Tao Ban, Hongxia Bao, Ying Zhang, Yang Zhang, Zheng Li, Lei Jiao   +27 more
wiley   +1 more source

Diabetic bone fragility through advanced glycation end product-collagen axis: Mechanisms and therapy of sodium glucose cotransporter 2 inhibitors. [PDF]

World J Diabetes
Li ZP, Luo C, Yu XM, Ye LY, Sun D, Duan CZ, Xu SY, Zeng MQ, Xu H, Peng ZY, Wang P, Wang YB, Ruan WJ, Xue ME, Zhang CJ, He DJ.   +15 more
europepmc   +1 more source