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Human Hemolysate Glycated Proteome
Analytical Chemistry, 2011Despite continuous advances in hyperglycemia treatments, a precise control through monitoring of glucose and glycated hemoglobin remains in most diabetic patients as the diagnosis/prognosis tool. An alternative perspective could be the discovery and quantitation of new blood glycated proteins formed by nonenzymatic reaction with circulatory glucose. As
Priego-Capote, Feliciano +6 more
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Glycated albumin and glycated hemoglobin levels in normal pregnancy
Biochemical Medicine and Metabolic Biology, 1988Glycated albumin levels showed a progressive increase during normal pregnancy. The mean values (mole hexose/mole protein) were 1.68 +/- 0.27 (n = 15) in nonpregnant women, 1.83 +/- 0.21 (n = 11) in first trimester, 2.00 +/- 0.41 (n = 13) in second trimester, and 2.42 +/- 0.49 (n = 15) in third trimester.
K B, Rai, A, Kumar, T N, Pattabiraman
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Glycation in diabetic nephropathy
Amino Acids, 2010The kidney is an extremely complex organ with broad ranging functions in the body, including but not restricted to waste excretion, ion and water balance, maintenance of blood pressure, glucose homeostasis, generation of erythropoietin and activation of vitamin D.
Forbes, Josephine M., Cooper, Mark E.
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Biogerontology, 2004
Glycation, a deleterious form of post-translational modification of macromolecules has been linked to diseases such as diabetes, cataract, Alzheimer's, dialysis related amyloidosis (DRA), atherosclerosis and Parkinson's as well as physiological aging.
George, Suji, S, Sivakami
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Glycation, a deleterious form of post-translational modification of macromolecules has been linked to diseases such as diabetes, cataract, Alzheimer's, dialysis related amyloidosis (DRA), atherosclerosis and Parkinson's as well as physiological aging.
George, Suji, S, Sivakami
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Nihon rinsho. Japanese journal of clinical medicine, 2010
Recent clinical studies have substantiated the concept of 'metabolic memory' in the pathogenesis of cardiovascular disease (CVD) in diabetes. Indeed, DCCT-EDIC Research, has revealed that intensive therapy during the DCCT reduces the risk of cardiovascular events by about 50% in type 1 diabetic patients 11 years after the end of the trial.
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Recent clinical studies have substantiated the concept of 'metabolic memory' in the pathogenesis of cardiovascular disease (CVD) in diabetes. Indeed, DCCT-EDIC Research, has revealed that intensive therapy during the DCCT reduces the risk of cardiovascular events by about 50% in type 1 diabetic patients 11 years after the end of the trial.
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Glycated Hemoglobin in Insulinoma
Endocrine Practice, 1998To determine whether preoperative levels of glycated hemoglobin (GHb) are lower in patients with functioning insulinoma and, if so, whether a distinct separation of GHb values from those in control subjects might serve for diagnosis.We examined preoperative GHb in consecutive patients (who had this measurement done) with surgically confirmed insulinoma
A A, Hassoun, F J, Service, A P, O'Brien
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Glycation Stimulates Amyloid Formation
Science of Aging Knowledge Environment, 2004Amyloidosis comprises a group of systemic and localized diseases with varied clinical presentations. In these diseases, amyloid forms when proteins with a largely α-helical structure lose their original conformation and are converted into a predominantly β-sheet form, thereby increasing their propensity to form highly insoluble and fibrillar aggregates.
Mark E, Obrenovich, Vincent M, Monnier
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Glycation in the cardiomyocyte
Glycation is a protein post-translational modification that can occur on lysine and arginine residues as a result of a non-enzymatic process known as the Maillard reaction. This modification is irreversible, so the only way it can be removed is by protein degradation and replacement.Christine E, Delligatti +1 more
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Advanced Glycation End Products
2011Prolonged hyperglycemia, dyslipidemia and oxidative stress in diabetes result in the increased production and accumulation of advanced glycation end products (AGEs) in the kidney. Covalent AGE modifications significantly influence the structure and function of key protein targets.
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