Obesity, EarlyView.ABSTRACT Objective This study compared the efficacy of metabolic/bariatric surgery (MBS) and GLP‐1 receptor agonists (GLP‐1 RAs), including dual GLP‐1/GIP analogues, for weight and metabolic outcomes in adults with obesity. Methods A network meta‐analysis of randomized controlled trials compared MBS or GLP‐1 RAs versus lifestyle intervention in adults ...
Lucas Sabatella +9 more
wiley +1 more source
Switch from premixed insulin analogue to degludec-liraglutide combination: a CGM study. [PDF]
Front Endocrinol (Lausanne)Kravos Tramšek NA, Koceva A, Krajnc M.
europepmc +1 more source
PROTEOMICS, EarlyView.ABSTRACT The EmDia trial, designed to study the effects of the sodium glucose cotransporter‐2 (SGLT2) inhibitor empagliflozin on cardiovascular comorbidities in type 2 diabetes mellitus (T2DM) patients, has been investigated for short‐term metabolic alterations by a limited set of clinical assays. To expand on this data, we report on the development of
Fabian Schmitt +7 more
wiley +1 more source
Differential prognostic value of glycemic dysregulation markers in critically ill individuals with ischemic stroke, with and without diabetes. [PDF]
Diabetol Metab SyndrFeng J +9 more
europepmc +1 more source
CPT: Pharmacometrics &Systems Pharmacology, EarlyView.ABSTRACT Dulaglutide, a long‐acting glucagon‐like peptide‐1 (GLP‐1) receptor agonist, is approved for improving glycemic control and reducing cardiovascular risks in patients with type 2 diabetes mellitus (T2DM). This research investigates the effect of dulaglutide on gastric emptying and its impact on the pharmacokinetics (PK) of orally administered ...
Maria M. Posada +9 more
wiley +1 more source
Probiotics, <i>prebiotics</i>, synbiotics, and FMT for glycemic control: A systematic review of clinical efficacy and mechanistic readouts in type 2 diabetes and related dysglycemia. [PDF]
Metabol OpenShalbaf N +3 more
europepmc +1 more source
eVLP‐Mediated Cas9 Delivery for Preventing IBMIR in Islet Transplantation
Small, EarlyView.Engineered virus‐like particles (eVLPs) are used to deliver Cas9 nuclease to knock out tissue factor (TF) and plasminogen activator inhibitor‐1 (PAI‐1) genes in pancreatic islets. The edited islets maintained viability and function, while reducing instant blood‐mediated inflammatory reaction (IBMIR) markers and improving glycemic control in diabetic ...
Manju Shrestha +6 more
wiley +1 more source
Small Science, EarlyView.Infected diabetic foot ulcer endangers patients with high amputation, disability, mortality risks, and heavy medical burdens. This review analyzes its pathogenic factors, the limitations of current treatments, the breakthroughs of responsive antimicrobial biomaterials, and the challenge of multifunctional biomaterial innovations for further developing ...
Yaqi Yao +8 more
wiley +1 more source
Comparative effectiveness of metformin and alogliptin combination therapy versus metformin monotherapy in patients with type 2 diabetes: an emulated target trial. [PDF]
BMC Endocr DisordCho J +15 more
europepmc +1 more source
Ketogenesis is Dispensable for the Metabolic Adaptations to Caloric Restriction
Aging Cell, EarlyView.In this study, we demonstrated that metabolic responses to a daily‐fed caloric restriction (CR) protocol remain robust in mice that cannot engage in canonical ketogenesis. This surprising finding is due to mice physiologically adapting to the daily bouts of fasting during CR by downregulating ketone production. ABSTRACT Caloric restriction (CR) extends
Chung‐Yang Yeh +13 more
wiley +1 more source