Results 231 to 240 of about 4,938,448 (288)

1‐Deoxynojirimycin Alleviates Osteoporosis via Promoting LRP5 Signaling in Osteoblasts and BMSCs

open access: yesPhytotherapy Research, EarlyView.
Graphical abstract of the potential mechanism by which DNJ promotes osteogenic differentiation in osteoblasts. DNJ improves LRP5 activity by directly binding to its extracellular domain, thereby facilitating β‐catenin's translocation from the cytoplasm to the nucleus.
Kainong Sun   +10 more
wiley   +1 more source

Oxyberberine Ameliorates Type 2 Diabetic Osteoporosis Through Sirtuin 3‐Associated Regulation of Autophagy and Ferroptosis in Bone Marrow Mesenchymal Stem Cells

open access: yesPhytotherapy Research, EarlyView.
Schematic overview of the in vivo and in vitro experimental designs used to investigate the protective effects of oxyberberine (OBB) against type 2 diabetic osteoporosis, including C‐Z treatment, Sirt3 knockdown, and assessments of osteogenesis, autophagy, oxidative stress, and ferroptosis. ABSTRACT Type 2 diabetic osteoporosis (T2DOP) is characterized
Jianan Huang   +10 more
wiley   +1 more source

Propolis Supplementation in Metabolic Dysfunction‐Associated Steatotic Liver Disease: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

open access: yesPhytotherapy Research, EarlyView.
In this systematic review and meta‐analysis of four randomized controlled trials (n = 178) of Iranian propolis in adults with MASLD, propolis supplementation was associated with improvement in ultrasound‐assessed hepatic steatosis (three trials, n = 156; RR 2.41, 95% CI 1.59–3.66) and a modest reduction in fasting glucose, with no significant effects ...
Ting‐An Kuo   +4 more
wiley   +1 more source

Fenestrated Microneedle Biosensor for Continuous In Vivo Lactate Monitoring in Interstitial Fluid

open access: yesSmall, EarlyView.
A fenestrated microneedle biosensor enables continuous transdermal monitoring of lactate in interstitial fluid while protecting the functional sensing interface during insertion into the skin. The platform delivers sensitive electrochemical lactate detection and distinguishes metabolic profiles in healthy and type 2 diabetic‐obese mice, and captures ...
Masoud Khazaei   +5 more
wiley   +1 more source

Anti‐obesity medications and incident ocular outcomes: A systematic review and network meta‐analysis

open access: yesVIEW, EarlyView.
In this systematic review and network meta‑analysis of 140 studies, anti‑obesity medications showed heterogeneous ocular safety profiles. Semaglutide was associated with higher NAION risk (observational data), whereas dual/multi‑agonists and glucagon‐like peptide‐1 receptor agonists demonstrated favourable glaucoma and overall ocular outcomes ...
Linge Jian   +5 more
wiley   +1 more source

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