Results 101 to 110 of about 69,432 (322)

Materials and System Design for Self‐Decision Bioelectronic Systems

Advanced Materials, EarlyView.
This review highlights how self‐decision bioelectronic systems integrate sensing, computation, and therapy into autonomous, closed‐loop platforms that continuously monitor and treat diseases, marking a major step toward intelligent, self‐regulating healthcare technologies.
Qiankun Zeng, Hong Liu, Yongheng Zhang, Youbin Zheng, Xuyin Ding, Mengni Zhu, Guoyue Shi, Yan Wang, Hossam Haick, Min Zhang   +9 more
wiley   +1 more source

Common Variants at 10 Genomic Loci Influence Hemoglobin A(1C) Levels via Glycemic and Nonglycemic Pathways [PDF]

, 2010
OBJECTIVE Glycated hemoglobin (HbA1c), used to monitor and diagnose diabetes, is influenced by average glycemia over a 2- to 3-month period. Genetic factors affecting expression, turnover, and abnormal glycation of hemoglobin could also be associated ...
Abecasis, G, Altshuler, D, Arking, D, Balkau, B, Barnes, D, Barroso, I, Boehnke, M, Boerwinkle, E, Bohm, B, Boinstein, SR, Bonnefond, A, Bonnycastle, LL, Boomsma, DI, Bottcher, Y, Bouatia-Naji, N, Bumpstead, S, Burnett-Miller, MS, Campbell, H, Cao, A, Chambers, J, Clark, R, Collins, FS, Coresh, J, de Geus, EJC, Dei, M, Deloukas, P, Devaney, JM, Doring, A, Dupuis, J, Egan, JM, Elosua, R, Epstein, SE, Erdmann, J, Ferrucci, L, Fleming, MD, Florez, JC, Forouhi, N, Fox, CS, Franklin, C, Franzosi, MG, Froguel, P, Gallina, S, Gieger, C, Goe, A, Graessler, J, Grallert, H, Greinacher, A, Groop, L, Hadley, D, Hakonarson, HH, Hall, A, Hamsten, A, Hayward, C, Heath, S, Heeney, MM, Herder, C, Homuth, G, Hottenga, JJ, Hunter-Merrill, R, Illig, T, Jackson, AU, Jula, A, Kao, WHL, Kathiresan, S, Khaw, KT, Kleber, M, Knouff, CW, Kong, A, Kooner, J, Kottgen, A, Kovacs, P, Krohn, K, Kuhne, B, Kuusisto, J, Laakso, M, Langenberg, C, Lathrop, M, Lecoeur, C, Li, M, Li, MY, Loos, RJF, Luan, JA, Lyssenko, V, Magi, R, Magnusson, PKE, Malarstig, A, Mangino, M, Martinez-Larrad, MT, Marz, W, McArdle, WL, McCarthy, MI, McPherson, R, Meigs, JB, Meisinger, C, Meitinger, T, Melander, O, Mohlke, KL, Mooser, VE, Morken, MA, Narisu, N, Nathan, DM, Nauck, M, O'Donne, C, Oexle, K, Olla, N, Pankow, JS, Payne, F, Peden, JF, Pedersen, NL, Peltonen, L, Perola, M, Polasek, O, Porcu, E, Procardis Consortium,, Prokopenko, I, Rader, DJ, Radke, D, Rathmann, W, Reilly, MP, Ricketts, SL, Ripatti, S, Roberts, R, Rocheleau, G, Roden, M, Rudan, I, Salomaa, V, Samani, NJ, Sandhu, MS, Sanna, S, Saxena, R, Schlessinger, D, Schunkert, H, Schwarz, P, Seedorf, U, Selvin, E, Serrano-Rios, M, Shrader, P, Silveira, A, Siscovick, D, Sladek, R, Song, K, Soranzo, N, Spector, TD, Stefansson, K, Steinthorsdottir, V, Stewart, AFR, Stolerman, E, Strachan, DP, Strawbridge, R, Stumvoll, M, Surakka, I, Swift, AJ, Tanaka, T, Teumer, A, Thorleifsson, G, Thorsteinsdottir, U, Tonjes, A, Uda, M, Usalai, G, Vitart, V, Voight, BF, Volzke, H, Wallaschofski, H, Wareham, NJ, Waterworth, DM, Watkins, H, Wheeler, E, Wichmann, HE, Wild, SH, Willemsen, G, Willenborg, C, Williams, GH, Wilson, JF, Winkelmann, J, Wright, AF, Wright, B, WTCCC,, Zabena, C, Zhao, JH   +178 more
core   +8 more sources

Hyperandrogenemia Induces Trophoblast Ferroptosis and Early Pregnancy Loss in Patients With PCOS via CMA‐Dependent FTH1 Degradation

Advanced Science, EarlyView.
In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou, Weijie Yang, Na Liu, Qing Liu, Jiamin Jin, Chenqiong Zhao, Xiaoying Jin, Miao Gui, Haiyan Zhu, Songying Zhang, Yinli Zhang   +10 more
wiley   +1 more source

NAFLD‐related hepatocellular carcinoma: The growing challenge

Hepatology, EarlyView., 2022
Risk and protective factors for NAFLD‐related hepatocellular carcinoma Abstract Hepatocellular carcinoma (HCC) is a common cause of cancer‐related mortality and morbidity worldwide. With the obesity pandemic, NAFLD‐related HCC is contributing to the burden of disease exponentially.
Pir Ahmad Shah, Rashmee Patil, Stephen A. Harrison   +2 more
wiley   +1 more source

Impact of early postoperative blood glucose variability on serum endocan level in cardiac surgery patients: a sub study of the ENDOLUNG observational study

Cardiovascular Diabetology, 2023
Background Early postoperative glycemic variability is associated with worse outcome after cardiac surgery, but the underlying mechanisms remain unknown.
Etienne Chazal, Lucas Morin, Sidney Chocron, Philippe Lassalle, Sebastien Pili-Floury, Lucie Salomon du Mont, David Ferreira, Emmanuel Samain, Andrea Perrotti, Guillaume Besch   +9 more
doaj   +1 more source

The Effect of Bariatric Surgery on Diabetic Retinopathy: Good, Bad, or Both? [PDF]

, 2016
Bariatric surgery, initially intended as a weight-loss procedure, is superior to standard lifestyle intervention and pharmacological therapy for type 2 diabetes in obese individuals.
Docherty, NG, Gorman, DM, Le Roux, CW
core   +3 more sources

Redox‐Responsive Tellurium‐Bridged Covalent Organic Frameworks/PEG Composites for Targeted Therapy of Diabetic Cardiomyopathy

Advanced Science, EarlyView.
This study unlocks the immense potential of COF@polymer nanocomposites as a multifunctional therapeutic platform for targeted drug delivery in diabetic cardiomyopathy. Abstract Diabetic cardiomyopathy, a major complication of diabetes, is strongly associated with elevated levels of glycated hemoglobin (HbA1c) and reactive oxygen species (ROS). However,
Jing Xue, Jialu Zhuang, Taotao Fan, Songtao Tang, Junjun Wang, Xiaohui Liu, Jian Liu, Jin Shi, Jiaji Li, Wanjun Li, Danyou Hu, Xiaoqian Zhang, Hua Wang, Guiyang Zhang   +13 more
wiley   +1 more source

Glycemic Variability: Clinical and Prognostic Significance

Diabetes Research - Open Journal, 2015
Minimizing development or progression of chronic diabetic micro and macro-vascu- lar complications has been always the goal of glycemic control. In recent years, much attention has been focused on the possibility that glycemic variability confers an additional risk factor for diabetic complications independent of glycated hemoglobin (HbA1c).
Kenneth Yu Hsiang Lin, Kai-Ju Huang, Chun-Pai Yang   +2 more
openaire   +1 more source

A Time‐Programmed Bilayer Wound Dressing for Dynamic Microenvironment Modulation and Full‐Thickness Regeneration in Diabetic Wounds

Advanced Science, EarlyView.
The Polyphenol+PDGF‐BB scaffold fabrication (Panel A) and its dual wound healing effects (Panel B: anti‐inflammation and accelerated tissue remodeling). ABSTRACT Chronic diabetic wounds suffer from dysfunctional repair programs due to accumulated advanced glycation end products (AGEs) and persistent inflammation in hyperglycemic microenvironments ...
Lei Yi, Wanqian Li, Ying Duanmu, Zihan Zhang, Shixuan Chen, Shichu Xiao, Lei Du, Miaomiao Wei   +7 more
wiley   +1 more source

Mediation Analysis Supports a Causal Relationship between Maternal Hyperglycemia and Placental DNA Methylation Variations at the Leptin Gene Locus and Cord Blood Leptin Levels. [PDF]

, 2020
Changes in fetal DNA methylation (DNAm) of the leptin (LEP) gene have been associated with exposure to maternal hyperglycemia, but their links with childhood obesity risk are still unclear.
Bouchard, Luigi, Breton, Edith, Cardenas, Andres, Fortin, Carol-Ann, Gagné-Ouellet, Valérie, Guérin, Renée, Hivert, Marie-France, Perron, Patrice, Thibeault, Kathrine   +8 more
core   +1 more source