Results 111 to 120 of about 1,258,513 (286)

Impact of cumulative glucocorticoid exposure on vancomycin clearance in hospitalized children: A retrospective cohort study

British Journal of Clinical Pharmacology, EarlyView.
Prior glucocorticoid exposure is associated with modestly increased vancomycin clearance in hospitalized children, partly mediated by renal function and inflammation and may contribute to subtherapeutic early drug exposure. Abstract Introduction Augmented renal clearance (ARC) can lead to subtherapeutic vancomycin exposure in children.
Kouki Tomari, Ruud H. J. Verstegen, Cintia Cruz, Erin Chung, Aleena Azim, Shinya Ito, Tamorah R. Lewis   +6 more
wiley   +1 more source

Model‐Informed Approaches for Pediatric Type 2 Diabetes Evidence Generation: Insights from a Model‐Based Longitudinal HbA1c Meta‐Analysis from EMA Marketing Authorization Applications

Clinical Pharmacology &Therapeutics, EarlyView.
Evidence generation for antihyperglycemic therapies in pediatric type 2 diabetes mellitus (T2DM) remains challenging, with most randomized trials failing to demonstrate statistically significant reductions in glycated hemoglobin (HbA1c), partly due to substantial between‐subject variability.
Pieter J. Colin, Efthymios Manolis, Jeroen V. Koomen   +2 more
wiley   +1 more source

A randomized trial of hyperglycemic control in pediatric intensive care. [PDF]

, 2014
BACKGROUND: Whether an insulin infusion should be used for tight control of hyperglycemia in critically ill children remains unclear. METHODS: We randomly assigned children (≤16 years of age) who were admitted to the pediatric intensive care unit (ICU ...
Allen, Elizabeth, Grieve, Richard, Morris, Kevin, Sadique, Zia, Parslow, Roger, Elbourne, Diana, CHiP Investigators, Macrae, Duncan, Pappachan, John, Tasker, Robert C   +9 more
core   +1 more source

Corrections of Equations on Glycemic Variability and Quality of Glycemic Control [PDF]

Diabetes Technology & Therapeutics, 2018
Irina, Gaynanova, Jacek, Urbanek, Naresh M, Punjabi   +2 more
openaire   +2 more sources

The association between Healthy Eating Index‐2020 and epilepsy: Insights based on NHANES from 2013 to 2018

Epileptic Disorders, EarlyView.
Abstract Background Epilepsy is a serious chronic brain disease. However, limited study is focused on the association between dietary pattern and epilepsy management. Hence, we aim to investigate the association between the Healthy Eating Index (HEI‐2020) and epilepsy odds.
Kun Yu, Yingxin Wang, Huaiqing Gao
wiley   +1 more source

Glycemic Variability, Hypoglycemia and Organ Failure in the Glucontrol Study

, 2011
Organ failure is the leading cause of intensive care unit (ICU) mortality. This research evaluates the influence of glycemic variability and hypoglycemia on organ failure rate.
Penning, S., Preiser, J-C., Desaive, T., Le Compte, A.J., Chase, Geoff   +4 more
core   +1 more source

What Makes Tight Glycemic Control Tight? The Impact of Variability and Nutrition in Two Clinical Studies [PDF]

, 2010
Tight glycemic control (TGC) remains controversial, and successful, consistent and effective protocols elusive. This research analyses data from 2 TGC trials for root causes of the differences achieved in control and thus potentially in glycemic and ...
Lin, J., Preiser, J-C., Desaive, T., Pretty, C.G., LeCompte, A.J., Suhaimi, F., Shaw, Geoff, Radermecker, R.P., Massion, P., Chase, Geoff   +9 more
core   +1 more source

Intermittent fasting with medium‐chain triglycerides in drug‐resistant epilepsy: A pilot crossover trial

Epilepsia, EarlyView.
Abstract Objective Ketogenic dietary therapies can reduce seizure frequency in drug‐resistant epilepsy, but adherence to the classical ketogenic diet is often poor. Intermittent fasting supplemented with medium‐chain triglycerides (MCTs) may offer a more feasible and less restrictive alternative.
Wiebke Hahn, Emily Falk, Ayla Balzter, Tobias Foer, Shanin Maierhofer, Sophia Jaumann, Sascha Strehlau, Leona Möller, Panagiota‐Eleni Tsalouchidou, Katja Menzler, Lars Timmermann, Susanne Knake   +11 more
wiley   +1 more source

Comparison of estimates of glycemia and glycemic variability.

, 2015
Values are mean (SD) unless otherwise indicated. Abbreviations: CGM, continuous glucose monitoring; SD, standard deviation; SE, standard error; SDws1and SDws4, standard deviation within time series of respectively 1 and 4 hours; CONGA1 and CONGA4 ...
Diana van Heemst (28182), Hanno Pijl (123561), Christa M. Cobbaert (772706), Anton J. de Craen (804152), Bart E. Ballieux (772707), Raymond Noordam (333224), Steffy W. Jansen (772704), Simon P. Mooijaart (293033), Abimbola A. Akintola (333226), Rudi G. Westendorp (772708)   +9 more
core   +1 more source

Healthy Snacks Elaborated With Decoction Residues of Hibiscus sabdariffa L: Physical and Sensory Characteristics

Food Chemistry International, EarlyView.
Healthy snacks formulated with food by‐products are gaining interest within the food industry. Decoction residues of Hibiscus sabdariffa (roselle) retain thermostable polyphenols. Extruded snacks enriched with roselle showed a reduction in the expansion index as the roselle concentration increased.
Monserrat Hernández‐Bautista, Edith Agama‐Acevedo, Erik Heredia‐Olea, Luis A. Bello‐Pérez   +3 more
wiley   +1 more source