Results 81 to 90 of about 1,258,513 (286)

Engineered Brain‐Targeted Exosomes Delivering FGF1 for Sustained Glycemic Regulation and Multitarget Neurovascular Protection in Diabetic Stroke

Advanced Science, EarlyView.
ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen, Chengxiang Zhang, Junhui Wang, Xichong Zhong, Shihao Chen, Xue Wang, Xiaokun Li, Li Lin   +7 more
wiley   +1 more source

Nerve conduction study of the association between glycemic variability and diabetes neuropathy

Diabetology & Metabolic Syndrome, 2018
Background It remains unclear whether glycemic variability is related to diabetes microvascular disease, especially diabetes peripheral neuropathy (DPN).
Miho Akaza, Itaru Akaza, Tadashi Kanouchi, Tetsuo Sasano, Yuki Sumi, Takanori Yokota   +5 more
doaj   +1 more source

Metabolic Memory in Cardiovascular Disease: Encoding, Propagation, and Therapeutic Targeting

Advanced Science, EarlyView.
Cardiovascular risk often persists after metabolic abnormalities are corrected. This conceptual Review frames such persistence as metabolic memory, encoded through a narrowing therapeutic window from reversible marks to irreversible damage, with continuous input from peripheral organs.
Cheng Cheng, Minghui Tang, Zhaobo Zhang, Ruoyi Qu, Jianfei Pei, Tian Liu, Siyao Qu, Shilong You, Shenshen Cui, Wenke Wang, Rui Zhao, Yingxian Sun, Naijin Zhang   +12 more
wiley   +1 more source

NAFLD‐related hepatocellular carcinoma: The growing challenge

Hepatology, EarlyView., 2022
Risk and protective factors for NAFLD‐related hepatocellular carcinoma Abstract Hepatocellular carcinoma (HCC) is a common cause of cancer‐related mortality and morbidity worldwide. With the obesity pandemic, NAFLD‐related HCC is contributing to the burden of disease exponentially.
Pir Ahmad Shah, Rashmee Patil, Stephen A. Harrison   +2 more
wiley   +1 more source

Comparisons of glycemic measures and glycemic variability measures between diabetic and control groups y.

, 2014
Data are presented as mean ± SD and were calculated from 72 hour recordings. P values were obtained by One-Way ANOVA. SD: standard deviation; CGM: continuous glucose monitoring; Multi-Scale GV: Multi-Scale glycemic variability; GVC: glycemic variability ...
Brad D. Manor (514438), Vera Novak (151416), Chung-Kang Peng (151408), Xingran Cui (514437), Amir Abduljalil (343697)   +4 more
core   +1 more source

The effect of hemodialysis on glycemic variability

Annales Academiae Medicae Silesiensis, 2019
Stały wzrost zapadalności na cukrzycę typu 2, będącą główną przyczyną schyłkowej niewydolności nerek u chorych hemodializowanych, stał się przedmiotem wielokierunkowych badań. Wiele uwagi poświęcono wpływowi hemodializy na wahania glikemii w trakcie zabiegu hemodializy oraz w okresach między zabiegami, jak również na różnice między zmiennością glikemii
Grzegorz Pruś, Magdalena Firlej-Pruś, Mirosław Śnit   +2 more
openaire   +1 more source

Programming Gut Microbiome Function Through Cross‐Feeding: From Ecological Mechanisms to Live Biotherapeutics

Advanced Science, EarlyView.
This graphical abstract presents gut microbial cross‐feeding through a Mechanism–Technology–Application framework. It summarizes major resource‐transfer modes, the experimental and computational tools used to establish causality, and potential interventions involving dietary substrates, live biotherapeutic products, and engineered microbes.
Chuankai Sun, Teng Ma, Hao Jin, Zelong Li, Yi Cheng, Jingjin Li, Lai‐Yu Kwok, Zhihong Sun   +7 more
wiley   +1 more source

Impact of early postoperative blood glucose variability on serum endocan level in cardiac surgery patients: a sub study of the ENDOLUNG observational study

Cardiovascular Diabetology, 2023
Background Early postoperative glycemic variability is associated with worse outcome after cardiac surgery, but the underlying mechanisms remain unknown.
Etienne Chazal, Lucas Morin, Sidney Chocron, Philippe Lassalle, Sebastien Pili-Floury, Lucie Salomon du Mont, David Ferreira, Emmanuel Samain, Andrea Perrotti, Guillaume Besch   +9 more
doaj   +1 more source

OAF Blocks SIAH1‐Mediated Degradation of SCPX, a Therapeutic Strategy for MASLD

Advanced Science, EarlyView.
This study shows OAF directly binds to SCPX and inhibits its interaction with the E3 ligase SIAH1, thereby protecting SCPX from ubiquitin‐dependent degradation and stabilizing its levels. This OAF‐SCPX axis represents a novel pathway in lipid homeostasis, highlighting OAF as a promising therapeutic candidate for MASLD.
Zongxi Li, Jingyue Song, Kaili Ma, Shunan Tang, Shuqian Wang, Wenya Ji, Chen Lu, Ting Zhang, Huaping Zheng, Xiaowei Zheng, Shanshan Lai, Cheng Deng   +11 more
wiley   +1 more source

Postprandial Hyperglycemia and Glycemic Variability

Diabetes Care, 2011
The aim of this article is to evaluate the pros and cons of a specific impact of postprandial hyperglycemia and glycemic variability on the—mainly cardiovascular (CV)—complications of diabetes, above and beyond the average blood glucose (BG) as measured by HbA1c or fasting plasma glucose (FPG).
Standl, Eberhard, Schnell, Oliver, Ceriello, Antonio   +2 more
openaire   +2 more sources