Results 91 to 100 of about 1,056,672 (415)

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Glycerol affects root development through regulation of multiple pathways in Arabidopsis. [PDF]

PLoS ONE, 2014
Glycerol metabolism has been well studied biochemically. However, the means by which glycerol functions in plant development is not well understood. This study aimed to investigate the mechanism underlying the effects of glycerol on root development in ...
Jun Hu, Yonghong Zhang, Jinfang Wang, Yongming Zhou   +3 more
doaj   +1 more source

Gas-Phase Lubrication of ta-C by Glycerol and Hydrogen Peroxide. Experimental and Computer Modeling [PDF]

, 2010
Tetrahedrally coordinated hydrogen-free amorphous diamond-like carbon coating (denoted as ta-C) presents ultralow friction under boundary lubrication conditions at 80 °C in presence of OH-containing molecules.
De Barros Bouchet, Maria-Isabel, Goddard, William A., III, Martin, Jean-Michel, Matta, Christine, Okuda, Sachiko, Sagawa, Takumaru, Zhang, Qing   +6 more
core   +1 more source

GLYCEROL AND GLYCEROL DEHYDROGENASE IN THE CONIDIA OF ASPERGILLUS ORYZAE

The Journal of General and Applied Microbiology, 1965
A polyol was isolated from the conidia of Aspergillus oryzae and identified as glycerol. A NADP specific glycerol dehydrogenase (glycerol:NADP oxidoreductase) was found in the conidia; substrate specificities, pH optimum, Michaelis constants, the effect of inhibitors and stoichiometry were studied.
Yonosuke Ikeda, Koki Horikoshi
openaire   +3 more sources

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Glycerol contained in vaping liquids affects the liver and aspects of energy homeostasis in a sex‐dependent manner

Physiological Reports, 2022
Vaping is increasingly popular among the young and adult population. Vaping liquids contained in electronic cigarettes (e‐cigarettes) are mainly composed of propylene glycol and glycerol, to which nicotine and flavors are added.
Ariane Lechasseur, Mathilde Mouchiroud, Félix Tremblay, Gabrielle Bouffard, Nadia Milad, Marie Pineault, Michaël Maranda‐Robitaille, Joanie Routhier, Marie‐Josée Beaulieu, Sophie Aubin, Mathieu Laplante, Mathieu C. Morissette   +11 more
doaj   +1 more source

Inhibition of Fructose-1,6-bisphosphatase by Aminoimidazole Carboxamide Ribotide Prevents Growth of Salmonella enterica purH Mutants on Glycerol [PDF]

, 2006
The enzyme fructose-1,6-bisphosphatase (FBP) is key regulatory point in gluconeogenesis. Mutants of Salmonella enterica lacking purH accumulate 5-amino-4-imidazole carboxamide ribotide (AICAR) and are unable to utilize glycerol as sole carbon and energy ...
Boyd, Jeffrey M., Dougherty, Michael J., Downs, Diana M.   +2 more
core   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Saccharomyces cerevisiae exhibiting a modified route for uptake and catabolism of glycerol forms significant amounts of ethanol from this carbon source considered as ‘non-fermentable’

Biotechnology for Biofuels, 2019
Background Due to its inevitable formation during biodiesel production and its relatively high degree of reduction, glycerol is an attractive carbon source for microbial fermentation processes.
Maximilian R. Aßkamp, Mathias Klein, Elke Nevoigt   +2 more
doaj   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source