Results 91 to 100 of about 969,294 (383)

Glycine Exhibits Neuroprotective Effects in Ischemic Stroke in Rats through the Inhibition of M1 Microglial Polarization via the NF-κB p65/Hif-1α Signaling Pathway

open access: yesJournal of Immunology, 2019
Glycine is a simple nonessential amino acid known to have neuroprotective properties. Treatment with glycine results in reduced infarct volume of the brain, neurologic function scores, and neuronal and microglial death in ischemic stroke injury ...
Rui Liu   +11 more
semanticscholar   +1 more source

Openings of the rat recombinant alpha1 homomeric glycine receptor as a function of the number of sgonist molecules bound [PDF]

open access: yes, 2002
The functional properties of rat homomeric {alpha}1 glycine receptors were investigated using whole-cell and outside-out recording from human embryonic kidney cells transfected with rat {alpha}1 subunit cDNA.
Beato, M.   +3 more
core  

Metabolism of Glycine.

open access: yesExperimental Biology and Medicine, 1951
SummaryThe metabolism of glycine in mice has been studied after a single injection of glycine-2-C14 by following the specific activity of the uncombined glycine in plasma, liver and skeletal muscle, as well as the specific activity of the respiratory CO2.
openaire   +3 more sources

In vivo evidence for glycyl radical insertion into a catalytically inactive variant of pyruvate formate‐lyase

open access: yesFEBS Letters, EarlyView.
Dimeric pyruvate formate‐lyase cleaves pyruvate using a radical‐based mechanism. G734 serves as a radical storage location, and the radical is transferred to the catalytic C419 residue. Mutation of the C418‐C419 pair causes loss of enzyme activity, but does not impede radical introduction onto G734. Therefore, cis‐ but not trans‐radical transfer occurs
Michelle Kammel   +2 more
wiley   +1 more source

Improvement of Possibilities of Treating Pneumonias in Patients on the Background of Acute Myeloblast Leucosis in the Aspect of Immunoresistance Mechanisms [PDF]

open access: yes, 2017
Aim: to analyze the influence of the immunomodeling preparation glutamyl-cysteinyl-glycine disodium (glutoxim) on indices of cellular and humoral immunity in patients with pneumonias on the background of acute myeloblast leucosis to form new approaches ...
Borisova, I. (Inna)
core   +2 more sources

Glycine and glycine receptor immunoreactivity in brain and spinal cord [PDF]

open access: yesThe Journal of Neuroscience, 1988
To study the distribution of glycine immunoreactive neurons in the spinal cord and brain, antisera were raised against glycine conjugated to protein carriers. High-titer rabbit glycine antiserum was purified by affinity chromatography. Testing against other amino acids and peptides with immuno dot blots and ELISA assays showed little apparent cross ...
AN van den Pol, T Gorcs
openaire   +3 more sources

P‐glycoprotein modulates the fluidity gradient of the plasma membrane of multidrug resistant CHO cells

open access: yesFEBS Letters, EarlyView.
To explore the impact of the overexpression of the multidrug‐transporter P‐glycoprotein (ABCB1) on membrane fluidity, we compared the transversal gradient of mobility and microviscosity in plasma membranes of drug‐sensitive Chinese hamster ovary cells (AuxB1) and their multidrug‐resistant derivatives (B30) using the fluorescent n‐(9‐anthroyloxy) fatty ...
Roger Busche   +2 more
wiley   +1 more source

Early Actions of Neurotransmitters During Cortex Development and Maturation of Reprogrammed Neurons

open access: yesFrontiers in Synaptic Neuroscience, 2019
The development of the brain is shaped by a myriad of factors among which neurotransmitters play remarkable roles before and during the formation and maturation of synaptic circuits.
Jorge Ojeda, Ariel Ávila
doaj   +1 more source

Excessive Substitution of Fish Meal with Fermented Soybean Meal Induces Oxidative Stress by Impairing Glutathione Metabolism in Largemouth Bass (Micropterus salmoides)

open access: yesAntioxidants, 2023
The application of fermented soybean meal (FSBM) is an effective strategy to alleviate the shortage of fish meal (FM) in aquaculture. However, an excessive substitution ratio often reduces fish growth and induces liver oxidative stress, while the ...
Qiang Chen   +6 more
doaj   +1 more source

Multifarious Beneficial Effect of Nonessential Amino Acid, Glycine: A Review

open access: yesOxidative Medicine and Cellular Longevity, 2017
Glycine is most important and simple, nonessential amino acid in humans, animals, and many mammals. Generally, glycine is synthesized from choline, serine, hydroxyproline, and threonine through interorgan metabolism in which kidneys and liver are the ...
Meerza Abdul Razak   +3 more
semanticscholar   +1 more source

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