Results 101 to 110 of about 780,935 (307)

Branched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing efficiency of fatty acid oxidation and acyl-glycine export

Molecular Metabolism, 2016
Objective A branched-chain amino acid (BCAA)-related metabolic signature is strongly associated with insulin resistance and predictive of incident diabetes and intervention outcomes.
P. White, A. Lapworth, J. An, Liping Wang, R. McGarrah, R. Stevens, O. Ilkayeva, Tabitha George, M. Muehlbauer, J. Bain, J. Trimmer, M. Brosnan, T. Rolph, C. Newgard   +13 more
semanticscholar   +1 more source

Bio‐Inspired Synthesis of Macroporous Single Crystal Particles as Scattering Agents

Advanced Functional Materials, EarlyView.
A general strategy is presented that delivers unique, single‐crystal microparticles that combine submicron macroporosity and uniform particle shapes. A bioinspired approach is used to occlude three distinct types of additives – polystyrene microspheres, polymer vesicles and amino acids – within calcite single crystals, and subsequent thermal annealing ...
Stephanie E. Foster, Gianni Jacucci, Ouassef Nahi, Thomas Kress, Zabeada Aslam, Stuart Micklethwaite, Alexander N. Kulak, Rik Drummond‐Brydson, Melinda J. Duer, Yi‐Yeoun Kim, Silvia Vignolini, Fiona C. Meldrum   +11 more
wiley   +1 more source

Glycine promotes longevity in Caenorhabditis elegans in a methionine cycle-dependent fashion

bioRxiv, 2018
The deregulation of metabolism is a hallmark of aging. As such, changes in the expression of metabolic genes and the profiles of amino acid levels are features associated with aging animals.
Yasmine J. Liu, G. Janssens, Rashmi Kamble, Arwen W. Gao, A. Jongejan, M. V. Weeghel, Alyson W. MacInnes, R. Houtkooper   +7 more
semanticscholar   +1 more source

Fusogenic RNA Nanomodules for Fusion‐Mediated and Multiplexed siRNA Delivery

Advanced Functional Materials, EarlyView.
A fusogenic lipid‐layered RNA nanomodules (L‐CRAMs) enable high‐capacity and long‐lasting siRNA delivery through membrane fusion. These nanomodules carry exceptionally large siRNA payloads, avoid conventional endosomal uptake, and release multiple functional siRNAs through Dicer‐mediated processing.
Sunghyun Moon, Iksoo Jang, Taehyeon Kim, Nayoung Yoon, Kyuha Yum, Jong Bum Lee   +5 more
wiley   +1 more source

Volatile Relay Biosensing and Mobile Phone Imaging for Detection of Influenza Virus

Advanced Functional Materials, EarlyView.
Detection of volatile organic compounds is performed via a coupled enzymatic assay with mobile phone detection of the signal. Specific application demonstrated herein is the detection of influenza virus, across multiple levels of biological complexity, up to patient‐derived samples.
Dante G. Andersen, Josefine H. Jakobsen, Mikkel Høj Nielsen, Shreyans Chatterjee, Detlef Michel, Jan Münch, Rüdiger Gross, Alexander N. Zelikin   +7 more
wiley   +1 more source

Glycine receptor mechanism illuminated by electron cryo-microscopy

Nature, 2015
The strychnine-sensitive glycine receptor (GlyR) mediates inhibitory synaptic transmission in the spinal cord and brainstem and is linked to neurological disorders, including autism and hyperekplexia.
Juan Du, Wei Lü, Shenping Wu, Yifan Cheng, E. Gouaux   +4 more
semanticscholar   +1 more source

An Edible Chitosan‐Based Acoustic Sensor for Sound‐Responsive Actuation in Edible Robots

Advanced Functional Materials, EarlyView.
This study introduces an edible acoustic sensor for robotic food and edible robotics. Built from a chitosan piezoelectric film between gold electrodes, the sensor enables acoustic communication through ON/OFF keying. Integrated into an edible robot with pneumatically actuated arms and neck, it responds to high‐frequency tones.
Valerio Francesco Annese, Bokeon Kwak, Gaia de Marzo, Giulia Coco, Valentina Antonaci, Leonardo Lamanna, Massimo De Vittorio, Dario Floreano, Mario Caironi   +8 more
wiley   +1 more source

Bioinspired Co‐Assembly Enables Multiscale Architected Hydrogels for 3D Printing With Integrated Antibacterial and Bioactive Functions

Advanced Functional Materials, EarlyView.
A multicomponent supramolecular hydrogel integrating cell‐adhesive and antibacterial peptides within an alginate‐cellulose nanofibril matrix is developed. Peptide co‐assembly simultaneously strengthens the hydrogel network, improves extrusion printability, and imparts cell‐adhesive and antibacterial functions, offering a versatile platform for ...
Mor Tsuriano‐Zernichov, Francesca Netti, Sigal Rencus‐Lazar, Moran Aviv, Lihi Adler‐Abramovich   +4 more
wiley   +1 more source

Lignin Mimicking Protein Methylation Augments the Efficacy of FOLFOX Chemotherapy by Anchoring Thymidylate Synthase

Advanced Materials, EarlyView.
Lignin‐mimicking protein methylation can enhance the efficacy and mitigate the toxicity of the classic FOLFOX chemotherapy regimen. ABSTRACT FOLFOX has served as the standard chemotherapy regimen for advanced stages, specifically in the treatment of pancreatic, colorectal, and bladder cancers.
Shiyao Song, Yan‐Lai Tang, Xiaoting Liu, Jiayi Zheng, Chong Wu, Tang Li, Junhong Ye, Dianmin Xia, Yong Mei, Jingxuan Ma, Libin Huang, Xuequn Luo, Liheng Chen, Yanlin Qin, Weiling He   +14 more
wiley   +1 more source

Self‐Assembled Monolayers in p–i–n Perovskite Solar Cells: Molecular Design, Interfacial Engineering, and Machine Learning–Accelerated Material Discovery

Advanced Materials, EarlyView.
This review highlights the role of self‐assembled monolayers (SAMs) in perovskite solar cells, covering molecular engineering, multifunctional interface regulation, machine learning (ML) accelerated discovery, advanced device architectures, and pathways toward scalable fabrication and commercialization for high‐efficiency and stable single‐junction and
Asmat Ullah, Ying Luo, Stefaan De Wolf
wiley   +1 more source