Results 51 to 60 of about 614,810 (345)

mTORC1 amplifies the ATF4-dependent de novo serine-glycine pathway to supply glycine during TGF-β1–induced collagen biosynthesis

Science Signaling, 2019
Through mTORC1 signaling, TGF-β1 stimulates glycine synthesis from glucose to support collagen production in lung fibroblasts. Glucose supports fibrosis Transforming growth factor–β (TGF-β) stimulates fibrosis by promoting the differentiation of ...
B. Selvarajah, I. Azuelos, M. Platé, D. Guillotin, E. Forty, Gregorio Contento, Hannah V. Woodcock, Matthew Redding, Adam R. Taylor, Gino Brunori, P. Durrenberger, R. Ronzoni, A. Blanchard, P. Mercer, D. Anastasiou, R. Chambers   +15 more
semanticscholar   +1 more source

Theoretical Investigation of Glycine Micro-Solvated. Energy and NMR Spin Spin Coupling Constants Calculations

Sci, 2021
Glycine in its neutral form can exist in the gas phase while its zwitterion form is more stable in water solution, but how many waters are actually necessary to stabilize the zwitterionic structure in the gas phase?
Maria Cristina Caputo, Patricio Federico Provasi   +1 more
doaj   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Ni-CeO₂/SBA-15 Catalyst Prepared by Glycine-Assisted Impregnation Method for Low-Temperature Dry Reforming of Methane

Crystals, 2022
Developing low-temperature nickel-based catalysts with good resistance to coking and sintering for dry reforming of methane (DRM) is of great significance.
Jiliang Yang, Dandan Gong, Xinkang Lu, Cui Han, Hui Liu, Luhui Wang   +5 more
doaj   +1 more source

The NMDA receptor activation by d-serine and glycine is controlled by an astrocytic Phgdh-dependent serine shuttle

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Phgdh is a crucial enzyme in the astrocytic synthesis of l-serine from glucose. Our study uncovers the role of glial-neuronal cross-talk in regulating NMDAR synaptic activation through the astrocytic export of Phgdh-derived l-serine to ...
S. Neame, Hazem Safory, I. Radzishevsky, Ayelet Touitou, Francesco Marchesani, Marialaura Marchetti, Shai Kellner, Shai Berlin, V. Foltyn, S. Engelender, J. Billard, Herman Wolosker   +11 more
semanticscholar   +1 more source

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

FEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg, Laura De Cnop, Bernd Nidetzky   +2 more
wiley   +1 more source

Glycine is able to induce both a motility speed in- and decrease during zebrafish neuronal migration

Communicative & Integrative Biology, 2018
Various neurotransmitters influence neuronal migration in the developing zebrafish hindbrain. Migrating tegmental hindbrain nuclei neurons (THNs) are governed by depolarizing neurotransmitters (acetylcholine and glutamate), and glycine. In mature neurons,
Ulrike Theisen, Sven Hey, Christian D. Hennig, Ralf Schnabel, Reinhard W. Köster   +4 more
doaj   +1 more source

Heterogeneous Signaling at GABA and Glycine Co-releasing Terminals

Frontiers in Synaptic Neuroscience, 2018
The corelease of several neurotransmitters from a single synaptic vesicle has been observed at many central synapses. Nevertheless, the signaling synergy offered by cotransmission and the mechanisms that maintain the optimal release and detection of ...
Karin R. Aubrey, Karin R. Aubrey, Karin R. Aubrey, Stéphane Supplisson   +3 more
doaj   +1 more source

Assessing the causal association of glycine with risk of cardio-metabolic diseases

Nature Communications, 2019
Circulating levels of glycine have previously been associated with lower incidence of coronary heart disease (CHD) and type 2 diabetes (T2D) but it remains uncertain if glycine plays an aetiological role.
L. Wittemans, L. Lotta, C. Oliver‐Williams, I. Stewart, P. Surendran, Savita Karthikeyan, F. Day, A. Koulman, F. Imamura, Lingyao Zeng, J. Erdmann, H. Schunkert, K. Khaw, J. Griffin, N. Forouhi, R. Scott, A. Wood, S. Burgess, J. Howson, J. Danesh, N. Wareham, A. Butterworth, C. Langenberg   +22 more
semanticscholar   +1 more source

In vivo evidence for glycyl radical insertion into a catalytically inactive variant of pyruvate formate‐lyase

FEBS Letters, EarlyView.
Dimeric pyruvate formate‐lyase cleaves pyruvate using a radical‐based mechanism. G734 serves as a radical storage location, and the radical is transferred to the catalytic C419 residue. Mutation of the C418‐C419 pair causes loss of enzyme activity, but does not impede radical introduction onto G734. Therefore, cis‐ but not trans‐radical transfer occurs
Michelle Kammel, A. F. Volker Wagner, R. Gary Sawers   +2 more
wiley   +1 more source