Results 31 to 40 of about 979,308 (296)

Conformational variability of the glycine receptor M2 domain in response to activation by different agonists [PDF]

, 2007
Models describing the structural changes mediating cys-loop receptor activation generally give little attention to the possibility that different agonists may promote activation via distinct M2 pore-lining domain structural rearrangements.
Akabas, Chang, Cymes, Cymes, Dahan, England, Gandhi, Grosman, Han, Hawthorne, Hawthorne, Hemmings, Kondratskaya, Kondratskaya, Law, Lee, Lewis, Lobo, Lynch, Lynch, Lynch, Miyazawa, Muroi, O'Shea, Paas, Rajendra, Shan, Unwin, Unwin, Webb, Wilson   +30 more
core   +3 more sources

¹H NMR Based Metabolomics in Human Sepsis and Healthy Serum

Metabolites, 2020
Early diagnosis is essential but challenging in severe sepsis. Quantifying and comparing metabolite concentrations in serum has been suggested as a new diagnostic tool.
Henna Jaurila, Vesa Koivukangas, Marjo Koskela, Fiia Gäddnäs, Sami Myllymaa, Arja Kullaa, Tuula Salo, Tero I. Ala-Kokko   +7 more
doaj   +1 more source

Synthesis, Neuroprotective Effect and Physicochemical Studies of Novel Peptide and Nootropic Analogues of Alzheimer Disease Drug

Pharmaceuticals, 2022
Glutamate is an excitatory neurotransmitter in the nervous system. Excessive glutamate transmission can lead to increased calcium ion expression, related to increased neurotoxicity.
Radoslav Chayrov, Tatyana Volkova, German Perlovich, Li Zeng, Zhuorong Li, Martin Štícha, Rui Liu, Ivanka Stankova   +7 more
doaj   +1 more source

Synthesis of cyclopropanes via organoiron methodology: stereoselective preparation of cis-2-(2’-carboxycyclopropyl)glycine [PDF]

, 2002
A stereoselective route to cis-2-(2′-carboxycyclopropyl)glycine has been developed. exo-Nucleophilic addition to the (bicyclo[5.1.0]octadienyl)iron(1+) cation establishes the relative stereochemistry at the cyclopropane ring and the α-stereocenter ...
Donaldson, William, Wallock, Nathaniel J
core   +2 more sources

Growth of New, Optically Active, Semi-Organic Single Crystals Glycine-Copper Sulphate Doped by Silver Nanoparticles

Applied Nano, 2023
The purpose of this study is to modify all physicochemical properties of glycine–copper sulphate single crystals, such as crystal habits, molar mass, thermal stability, optical activity, and electrical properties.
Rasmiah Saad A. Almufarij, Alaa El-Deen Ali, Mohamed Elsayed Elba, Howida Eid Okab, Ollaa Moftah Mailoud, Hamida Abdel-Hamid, Howida Abouel Fetouh Elsayed   +6 more
doaj   +1 more source

Excessive Substitution of Fish Meal with Fermented Soybean Meal Induces Oxidative Stress by Impairing Glutathione Metabolism in Largemouth Bass (Micropterus salmoides)

Antioxidants, 2023
The application of fermented soybean meal (FSBM) is an effective strategy to alleviate the shortage of fish meal (FM) in aquaculture. However, an excessive substitution ratio often reduces fish growth and induces liver oxidative stress, while the ...
Qiang Chen, Congcong Wang, Yulong Sun, Yan Chen, Songming Chen, Tao Han, Jiteng Wang   +6 more
doaj   +1 more source

C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins [PDF]

, 2014
An expanded GGGGCC repeat in C9orf72 is the most common genetic cause of frontotemporal dementia and amyotrophic lateral sclerosis. A fundamental question is whether toxicity is driven by the repeat RNA itself and/or by dipeptide repeat proteins ...
Cabecinha, M, Clayton, EL, Cleverley, K, Devoy, A, Dols, J, Fisher, EMC, Fratta, P, Grönke, S, Hendrich, O, Isaacs, AM, Mizielinska, S, Moens, T, Niccoli, T, Nicoll, AJ, Norona, FE, Partridge, L, Pickering-Brown, S, Pietrzyk, J, Ridler, CE, Woollacott, IOC   +19 more
core   +1 more source

In vivo detection of γ-glutamyl-transferase up-regulation in glioma using hyperpolarized γ-glutamyl-[1-13C]glycine. [PDF]

, 2020
Glutathione (GSH) is often upregulated in cancer, where it serves to mitigate oxidative stress. γ-glutamyl-transferase (GGT) is a key enzyme in GSH homeostasis, and compared to normal brain its expression is elevated in tumors, including in primary ...
Batsios, Georgios, Cao, Peng, Gillespie, Anne Marie, Larson, Peder, Najac, Chloé, Ronen, Sabrina M, Saito, Yutaro, Sando, Shinsuke, Subramani, Elavarasan, Viswanath, Pavithra, Yoshihara, Hikari AI   +10 more
core   +1 more source

Glycine Supplementation Enhances the Growth of Sow-Reared Piglets with Intrauterine Growth Restriction

Animals
Glycine has the greatest rate of deposition in whole-body proteins among all amino acids in neonates, but its provision from sow’s milk meets only 20% of the requirement of suckling piglets.
Shengdi Hu, David W. Long, Fuller W. Bazer, Robert C. Burghardt, Gregory A. Johnson, Guoyao Wu   +5 more
doaj   +1 more source

Microstructures as Models for Origin of Life in Hot Water: Hydrogen-Assisted Self-Assembly of Glycine and Alanine Zwitterions

Hydrogen
Building on the early investigation by Sidney W. Fox that dry-heated amino acids can spontaneously form microspheres, this research studies the self-organization of glycine and alanine with hydrogen in a liquid system. This study aimed to investigate the
Ignat Ignatov
doaj   +1 more source