Results 51 to 60 of about 780,935 (307)

Muscle-Liver Trafficking of BCAA-Derived Nitrogen Underlies Obesity-Related Glycine Depletion

Cell Reports, 2020
SUMMARY Glycine levels are inversely associated with branched-chain amino acids (BCAAs) and cardiometabolic disease phenotypes, but biochemical mechanisms that explain these relationships remain uncharted. Metabolites and genes related to BCAA metabolism
P. White, A. Lapworth, R. McGarrah, L. Kwee, Scott B. Crown, O. Ilkayeva, J. An, M. W. Carson, Bridgette A. Christopher, James R. Ball, Michael N. Davies, Lilja Kjalarsdóttir, Tabitha George, Michael J. Muehlbauer, James R. Bain, R. Stevens, T. Koves, Deborah M. Muoio, Joseph Brozinick, R. E. Gimeno, M. Brosnan, Timothy P. Rolph, William E. Kraus, Svati H. Shah, C. B. Newgard   +24 more
semanticscholar   +1 more source

Metabolism of Glycine.

Experimental Biology and Medicine, 1951
SummaryThe metabolism of glycine in mice has been studied after a single injection of glycine-2-C14 by following the specific activity of the uncombined glycine in plasma, liver and skeletal muscle, as well as the specific activity of the respiratory CO2.
openaire   +2 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferation

Science, 2012
More Glycine, Please To better characterize metabolic properties of cancer cells, Jain et al. (p. 1040; see the Perspective by Tomita and Kami) measured systematically the concentrations of hundreds of metabolites in cell culture medium in which 60 ...
Mohit M. Jain, R. Nilsson, Sonia Sharma, Nikhil Madhusudhan, T. Kitami, Amanda L. Souza, Ran Kafri, M. Kirschner, C. Clish, V. Mootha   +9 more
semanticscholar   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

mTORC1 amplifies the ATF4-dependent de novo serine-glycine pathway to supply glycine during TGF-β1––induced collagen biosynthesis

Science Signaling, 2019
Through mTORC1 signaling, TGF-β1 stimulates glycine synthesis from glucose to support collagen production in lung fibroblasts. Glucose supports fibrosis Transforming growth factor–β (TGF-β) stimulates fibrosis by promoting the differentiation of ...
B. Selvarajah, I. Azuelos, M. Platé, D. Guillotin, E. Forty, Gregorio Contento, Hannah V. Woodcock, Matthew Redding, Adam R. Taylor, Gino Brunori, P. Durrenberger, R. Ronzoni, A. Blanchard, P. Mercer, D. Anastasiou, R. Chambers   +15 more
semanticscholar   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Stimulation Effects of Foliar Applied Glycine and Glutamine Amino Acids on Lettuce Growth

Open Agriculture, 2019
Amino acids have various roles in plant metabolism, and exogenous application of amino acids may have benefits and stimulation effects on plant growth and quality.
Yaghoub Aghaye Noroozlo, M. Souri, M. Delshad   +2 more
semanticscholar   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source