Results 71 to 80 of about 1,184,099 (376)

Stimulation Effects of Foliar Applied Glycine and Glutamine Amino Acids on Lettuce Growth

Open Agriculture, 2019
Amino acids have various roles in plant metabolism, and exogenous application of amino acids may have benefits and stimulation effects on plant growth and quality.
Yaghoub Aghaye Noroozlo, M. Souri, M. Delshad   +2 more
semanticscholar   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Radiolysis of Amino Acids by Heavy and Energetic Cosmic Ray Analogs in Simulated Space Environments: $\alpha$-Glycine Zwitterion Form

, 2014
In this work, we studied the stability of the glycine molecule in the crystalline zwitterion form, known as {\alpha}-glycine ($^{+}$NH$_{3}$CH$_{2}$COO$^{-}$) under action of heavy cosmic ray analogs.
Andrade, Diana P. P., Boduch, Philippe, Pilling, Sergio, Portugal, Williamary, Rothard, Hermann   +4 more
core   +3 more sources

The NMDA receptor activation by d-serine and glycine is controlled by an astrocytic Phgdh-dependent serine shuttle

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Phgdh is a crucial enzyme in the astrocytic synthesis of l-serine from glucose. Our study uncovers the role of glial-neuronal cross-talk in regulating NMDAR synaptic activation through the astrocytic export of Phgdh-derived l-serine to ...
S. Neame, Hazem Safory, I. Radzishevsky, Ayelet Touitou, Francesco Marchesani, Marialaura Marchetti, Shai Kellner, Shai Berlin, V. Foltyn, S. Engelender, J. Billard, Herman Wolosker   +11 more
semanticscholar   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Genotype-phenotype correlation study in 364 osteogenesis imperfecta Italian patients [PDF]

, 2019
Osteogenesis imperfecta (OI) is a rare genetic disorder of the connective tissue and 90% of cases are due to dominant mutations in COL1A1 and COL1A2 genes.
Boarini, Manila, Celli, Mauro, Corsini, Serena, D'Eufemia, Patrizia, Gnoli, Maria, Maioli, Margherita, Mordenti, Marina, Pedrini, Elena, Sangiorgi, Luca, Tremosini, Morena, Versacci, Paolo, Zambrano, Anna   +11 more
core   +1 more source

Assessing the causal association of glycine with risk of cardio-metabolic diseases

Nature Communications, 2019
Circulating levels of glycine have previously been associated with lower incidence of coronary heart disease (CHD) and type 2 diabetes (T2D) but it remains uncertain if glycine plays an aetiological role.
L. Wittemans, L. Lotta, C. Oliver‐Williams, I. Stewart, P. Surendran, Savita Karthikeyan, F. Day, A. Koulman, F. Imamura, Lingyao Zeng, J. Erdmann, H. Schunkert, K. Khaw, J. Griffin, N. Forouhi, R. Scott, A. Wood, S. Burgess, J. Howson, J. Danesh, N. Wareham, A. Butterworth, C. Langenberg   +22 more
semanticscholar   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Multifarious Beneficial Effect of Nonessential Amino Acid, Glycine: A Review

Oxidative Medicine and Cellular Longevity, 2017
Glycine is most important and simple, nonessential amino acid in humans, animals, and many mammals. Generally, glycine is synthesized from choline, serine, hydroxyproline, and threonine through interorgan metabolism in which kidneys and liver are the ...
Meerza Abdul Razak, P. S. Begum, B. Viswanath, S. Rajagopal   +3 more
semanticscholar   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source