Results 81 to 90 of about 969,294 (383)
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance Phgdh is a crucial enzyme in the astrocytic synthesis of l-serine from glucose. Our study uncovers the role of glial-neuronal cross-talk in regulating NMDAR synaptic activation through the astrocytic export of Phgdh-derived l-serine to ...
S. Neame +11 more
semanticscholar +1 more source
Conformational variability of the glycine receptor M2 domain in response to activation by different agonists [PDF]
, 2007 Models describing the structural changes mediating cys-loop receptor activation generally give little attention to the possibility that different agonists may promote activation via distinct M2 pore-lining domain structural rearrangements.
Akabas +30 more
core +3 more sources
A predator-prey interaction between a marine Pseudoalteromonas sp. and Gram-positive bacteria [PDF]
, 2020 Predator-prey interactions play important roles in the cycling of marine organic matter. Here we show that a Gram-negative bacterium isolated from marine sediments (Pseudoalteromonas sp.
Chen, Xiu-Lan +16 more
core +2 more sources
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
Glycine is able to induce both a motility speed in- and decrease during zebrafish neuronal migration
Communicative & Integrative Biology, 2018 Various neurotransmitters influence neuronal migration in the developing zebrafish hindbrain. Migrating tegmental hindbrain nuclei neurons (THNs) are governed by depolarizing neurotransmitters (acetylcholine and glutamate), and glycine. In mature neurons,
Ulrike Theisen +4 more
doaj +1 more source
Heterogeneous Signaling at GABA and Glycine Co-releasing Terminals
Frontiers in Synaptic Neuroscience, 2018 The corelease of several neurotransmitters from a single synaptic vesicle has been observed at many central synapses. Nevertheless, the signaling synergy offered by cotransmission and the mechanisms that maintain the optimal release and detection of ...
Karin R. Aubrey +3 more
doaj +1 more source
Assessing the causal association of glycine with risk of cardio-metabolic diseases
Nature Communications, 2019 Circulating levels of glycine have previously been associated with lower incidence of coronary heart disease (CHD) and type 2 diabetes (T2D) but it remains uncertain if glycine plays an aetiological role.
L. Wittemans +22 more
semanticscholar +1 more source
Ab initio Molecular Dynamics Study of Glycine Intramolecular Proton Transfer in Water
, 2005 We use ab initio molecular dynamics simulations to quantify structural and thermodynamic properties of a model proton transfer reaction that converts a neutral glycine molecule, stable in the gas phase, to the zwitterion that predominates in aqueous ...
Leung, Kevin, Rempe, Susan B.
core +1 more source
FEBS Letters, EarlyView.UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg +2 more
wiley +1 more source
A Water Cluster Conduit in Crystal
Molecules, 2017 The crystal structure of compound (1), [CuCl(phen)(H2NCH2COO)]∙4H2O, reveals an unusual hydrogen-bond water cluster aggregate T6(2)6(2). Four water molecules in (1) form an isolated water cluster, [(H2O)14]n, resembling a “phenanthro-[1,2]phenanthrene ...
Fangfang Jian, E Liu, Jiao Xu
doaj +1 more source