Results 161 to 170 of about 1,587,740 (262)

ATL2 Recruits TRAK1 to Promote Mitochondrial Transport at ER–Mitochondria Contact Sites

Advanced Science, EarlyView.
ABSTRACT Mitochondrial transport and distribution are crucial for cellular homeostasis, yet whether and how they are regulated by endoplasmic reticulum (ER)–mitochondria contact sites remains unclear. Here, we demonstrate that the ER protein atlastin‐2 (ATL2) orchestrates mitochondrial transport and distribution by promoting assembly of the transport ...
Yiru Cheng, Peiyuan Chai, Xiayuhe Pei, Yiwen Chen, Xiaoshuai Huang, Bei Liu, Yiqian Wu, Junlin Teng, Pengli Zheng, Jianguo Chen   +9 more
wiley   +1 more source

Dynamics and Interplay of the Binding Pockets in the Glycine Receptor. [PDF]

J Chem Inf Model
Xue G, Clark JA, Kemble-Diaz C, Crnjar A, Molteni C.   +4 more
europepmc   +1 more source

Glycine soja USDA GRIN: PI 548656 Genome sequencing and assembly

, 2018
The aims of this project were to generate a high-quality reference genome assembly for Glycine soja accession PI 483463, which shows high genotypic diversity with respect to elite cultivars from Glycine max (soybean). The assembly incorporates PacBio and
Glycine max cv Lee and Glycine soja PI 483463 sequencing consortium (17856182), SoyBase (17856185), USDA-ARS (17854919)   +2 more
core  

Single‐Cell Transcriptomics and Metabolomics Reveal Glutamate Dehydrogenase as a Central Regulator of Nitrogen Metabolic Remodeling During Alkalinity Adaptation in Crustaceans

Advanced Science, EarlyView.
Single‐cell transcriptomics reveals the cellular response of Macrobrachium hainanense to carbonate alkalinity stress. Alkalinity stress impairs branchial ammonia excretion, induces mitochondrial dysfunction, and drives cell‐type‐specific changes in gills and hemocytes.
Yiting Jin, Zhimin Lv, Chao Bian, Qibin Yang, Na Zhou, Jianguang Qin, Shengming Sun   +6 more
wiley   +1 more source

Glycine receptor autoantibody binding to the extracellular domain is independent from receptor glycosylation. [PDF]

Front Mol Neurosci, 2023
Rauschenberger V, Piro I, Kasaragod VB, Hörlin V, Eckes AL, Kluck CJ, Schindelin H, Meinck HM, Wickel J, Geis C, Tüzün E, Doppler K, Sommer C, Villmann C.   +13 more
europepmc   +1 more source

Enhancement of glycine receptor function by ethanol: role of phosphorylation

, 1998
1. The effects of several kinase inhibitors (staurosporine, GF 109203X, H89, KN62, genistein) and of the phosphatase inhibitor calyculin A were studied on the ethanol potentiation and on the function of homomeric alpha1 glycine receptor expressed in ...
Harris RA, Martinez LD, Wick MJ, Mascia MP   +3 more
core  

DDX3x Regulates NINJ1 Transcription via Histone Lactylation in Sepsis Associated‐Acute Kidney Injury

Advanced Science, EarlyView.
This study identifies a potential therapeutic approach for sepsis‐associated acute kidney injury (SA‐AKI). We found that during SA‐AKI, reduced expression of DDX3x in renal tubular epithelial cells mediates histone delactylation, which in turn upregulates NINJ1 transcription and triggers tubular cell death. Conversely, Odetiglucan confers protection by
Hongyu Liang, Jihong Jiang, Huanxin Yin, Chunyan Liu, Hongjun Huang, Yan Luo, Minmin Zhu, Qiuyun Wang   +7 more
wiley   +1 more source

Progressive Encephalomyelitis With Rigidity and Myoclonus With Glycine Receptor Antibodies: Clinical Features and Outcomes. [PDF]

Neurol Neuroimmunol Neuroinflamm
Guasp M, Saiz A, Ruiz-Vives M, Almendrote M, Bruna J, González-Menacho J, Kaneko J, Martín-Aguilar L, Martínez-García FA, Noda K, Ruiz Molina A, Sequeiros S, Simabukuro MM, Takenaka M, Zurdo M, Dalmau JO, Iizuka T, Graus F.   +17 more
europepmc   +1 more source

Structure and Mechanism of Glycine Receptor Elucidated by Cryo-Electron Microscopy. [PDF]

Front Pharmacol, 2022
Zhu H.
europepmc   +1 more source

Transcription Factor HOXC11 Drives Colorectal Cancer Progression and Metastasis via CAMK2A‐Dependent CXCL5 Upregulation

Advanced Science, EarlyView.
HOXC11 drives colorectal cancer progression by transcriptionally activating CAMK2A, which triggers NF‐κB–dependent CXCL5 upregulation. CXCL5–CXCR2 signaling further reinforces HOXC11 expression through the ERK1/2–SP1 axis, forming a prometastatic positive feedback loop that is effectively disrupted by combined CAMK2A and CXCR2 inhibition.
Qingyang Sun, Hengjie Xu, Sheng Yang, Jiahui Zhou, Chuanxin Tian, Hongxu Nie, Chi Jin, Tuo Wang, Zhihao Chen, Junwei Tang, Yifei Feng, Xiaowei Wang, Yueming Sun   +12 more
wiley   +1 more source