Results 171 to 180 of about 258,627 (303)

DMS‐MaPseq and DREEM Analyses Implicate the Critical Role of RNA Structural Dynamics in Turnip Yellow Mosaic Virus Pathogenicity

Advanced Science, EarlyView.
RNA structural profiling of Turnip Yellow Mosaic Virus by DMS‐MaPseq and DREEM analyses uncover that viral genome‐wide RSS is highly complicated and heterogeneous, with alternative RSSs widely distributed across the genome. Notably, the viral 3’ tRNA‐like structure adopts alternative conformations in vivo.
Jiaying Zhu, Changhao Li, Chisimbily Onyia, Xindi Li, Xingxing Yan, Songxiao Zhong, Taerin Oh, Xiuren Zhang   +7 more
wiley   +1 more source

Structure and Mechanism of Glycine Receptor Elucidated by Cryo-Electron Microscopy. [PDF]

Front Pharmacol, 2022
Zhu H.
europepmc   +1 more source

Effects of Withania somnifera on human glycine receptor

, 2016
The human glycine receptor, a ligand-gated ion channel permeable to chloride, is a major player in inhibitory neurotransmission within the spinal cord and brainstem. Inhibitory neurotransmission is crucial in regulating circuits within the nervous system.
Halpin, Elizabeth Sullivan
core  

Master Regulator SMC1A, Stabilized by N6‐Methyladenosine Reader IGF2BP1, Promotes HCC Progression Through Facilitating Enhancer–Promoter Interaction of Nestin

Advanced Science, EarlyView.
IGF2BP1‐mediated m6A stabilization sustains SMC1A expression, enabling cohesin‐associated chromatin regulation of Nestin in hepatocellular carcinoma. This work reveals an epitranscriptomic‐chromatin‐cytoskeletal regulatory axis linked to malignant phenotypes and identifies SMC1A as a biologically relevant vulnerability in HCC.
Zhenxiang Peng, Diguang Wen, Lu Zeng, Lin Lv, Shengtao Liao, Wenguang Zhang, Zhechuan Mei, Chuanfei Li   +7 more
wiley   +1 more source

Progressive Encephalomyelitis With Rigidity and Myoclonus With Glycine Receptor Antibodies: Clinical Features and Outcomes. [PDF]

Neurol Neuroimmunol Neuroinflamm
Guasp M, Saiz A, Ruiz-Vives M, Almendrote M, Bruna J, González-Menacho J, Kaneko J, Martín-Aguilar L, Martínez-García FA, Noda K, Ruiz Molina A, Sequeiros S, Simabukuro MM, Takenaka M, Zurdo M, Dalmau JO, Iizuka T, Graus F.   +17 more
europepmc   +1 more source

A case of unusual presentation with anti-glycine receptor (GlyR) and myelin oligodentrocyte glycoprotein (MOG) antibody. [PDF]

Clin Park Relat Disord, 2023
Kalampokini S, Motkova I, Bargiotas P, Artemiadis A, Zis P, Hadjigeorgiou GM.   +5 more
europepmc   +1 more source

Stage‐Specific H3K14 and H3K23 Succinylation Orchestrates Insect Metamorphosis and Oogenesis

Advanced Science, EarlyView.
Stage‐specific succinylation of histone H3 at lysine 14 and 23 differentially controls insect metamorphosis and oogenesis through distinct GPCR‐PKC signaling cascades, revealing an evolutionarily conserved epigenetic mechanism that coordinates key life‐history traits.
Yu‐Pu Jing, Lunjie Li, Libin Yang, Lin‐Jie Zhang, Qiang Yan, Ci Zhang, Zanrong Wen, Guangze Yu, Qian Li, Shutang Zhou   +9 more
wiley   +1 more source

Binding patterns of glycine receptor autoantibodies are related to clinical syndromes. [PDF]

Acta Neuropathol Commun
Piro I, Wiessler AL, Kakavela E, Baykan B, Tüzün E, Villmann C, Sommer C.   +6 more
europepmc   +1 more source

Nociception in the Glycine Receptor Deficient Mutant Mouse Spastic. [PDF]

Front Mol Neurosci, 2022
Groemer TW, Triller A, Zeilhofer HU, Becker K, Eulenburg V, Becker CM.   +5 more
europepmc   +1 more source

PIEZO1 is Required for Acute Myeloid Leukemia Progression and Leukemia Stem Cell Maintenance via HIF1A‐SLC7A11 Axis‐Mediated Ferroptosis Defense

Advanced Science, EarlyView.
This study identifies the mechanosensor PIEZO1 as a key factor in promoting acute myeloid leukemia progression and uncovers a ferroptosis defense system mediated by PIEZO1‐HIF1A‐SLC7A11 axis that is essential for leukemia stem cell maintenance. This ferroptotic defense system may represent a unique vulnerability for leukemia stem cells, providing a ...
Tiantian Zhang, Ziyan Cao, Kexin Gao, Shuxin Yao, Yanbing Zheng, Manman Cui, Rong Yin, Guoqiang Han, Jin Hu, Chengyi Wang, Haojian Zhang   +10 more
wiley   +1 more source