Results 171 to 180 of about 394,690 (299)

Structure and Mechanism of Glycine Receptor Elucidated by Cryo-Electron Microscopy. [PDF]

Front Pharmacol, 2022
Zhu H.
europepmc   +1 more source

FASLG Derived from Fibroblasts in Hydroxyapatite‐Rich Microenvironment Induces Urothelial Anoikis to Trigger Randall's Plaque Exposure

Advanced Science, EarlyView.
Randall's plaques (RP) serve as the nidus for calcium oxalate (CaOx) kidney stones. The current study reveals that hydroxyapatite (HAP) crystals activate the THY1–GSK3α/β–β‐catenin axis in renal interstitial fibroblasts (hRIFs), inducing FASLG secretion.
Minghui Liu, Maolan Wu, Meng Gao, Yongchao Li, Miao Yuan, Zhangcheng Liao, Zhi Liu, Yizhou Wang, Yu Cui, Jinbo Chen, Cheng He, Zhiyong Chen, Feng Zeng, Hequn Chen, Zewu Zhu   +14 more
wiley   +1 more source

Progressive Encephalomyelitis With Rigidity and Myoclonus With Glycine Receptor Antibodies: Clinical Features and Outcomes. [PDF]

Neurol Neuroimmunol Neuroinflamm
Guasp M, Saiz A, Ruiz-Vives M, Almendrote M, Bruna J, González-Menacho J, Kaneko J, Martín-Aguilar L, Martínez-García FA, Noda K, Ruiz Molina A, Sequeiros S, Simabukuro MM, Takenaka M, Zurdo M, Dalmau JO, Iizuka T, Graus F.   +17 more
europepmc   +1 more source

A case of unusual presentation with anti-glycine receptor (GlyR) and myelin oligodentrocyte glycoprotein (MOG) antibody. [PDF]

Clin Park Relat Disord, 2023
Kalampokini S, Motkova I, Bargiotas P, Artemiadis A, Zis P, Hadjigeorgiou GM.   +5 more
europepmc   +1 more source

Dose‐Dependent Reprogramming of Chromatin Accessibility by SOX4 Drives the Transcriptional Response to Iron Overload

Advanced Science, EarlyView.
This study demonstrates that iron overload triggers widespread chromatin compaction and transcriptional repression in human granulosa cells, recapitulating features of endometriosis. The epigenetic reprogramming is orchestrated by a TFEB‐SOX4‐SWI/SNF axis, with SOX4 acting as a central, dosage‐sensitive regulator.
Feifei Li, Yaoqiu Wu, Guangyu Yang, Jingyi Lai, Xiaoyue Sun, Liyan Wang, Xiaoli Li, Jing Zhang, Qingxue Zhang, Hui Chen, Haiyan Lin, Bingxiang Xu, Junfeng Zhang, Hailong Wang, Anming Meng, Chunwei Cao   +15 more
wiley   +1 more source

Binding patterns of glycine receptor autoantibodies are related to clinical syndromes. [PDF]

Acta Neuropathol Commun
Piro I, Wiessler AL, Kakavela E, Baykan B, Tüzün E, Villmann C, Sommer C.   +6 more
europepmc   +1 more source

Nociception in the Glycine Receptor Deficient Mutant Mouse Spastic. [PDF]

Front Mol Neurosci, 2022
Groemer TW, Triller A, Zeilhofer HU, Becker K, Eulenburg V, Becker CM.   +5 more
europepmc   +1 more source

A Circuit of Mechanically Regulated Transcription Factors Balances Regenerative and Fibrotic Memory of Mesenchymal Stromal Cells

Advanced Science, EarlyView.
Producing MSCs on rigid culture substrates induces a scar‐making phenotype, jeapordizing therapeutic success. ‘Tissue‐soft’ surfaces prevent MSC fibrogenesis and preserve regenerative traits. An epigenetic network, driven by HOXA11 and SALL1, maintains ‘soft memory’ by keeping chromatin open in relaxed MSCs, promoting anti‐fibrotic programs.
Fereshteh Sadat Younesi, Andrew E. Miller, Li Diao, Xinying Guo, Natalie Andonian, Elham Karimizadeh, Thomas H. Barker, Boris Hinz   +7 more
wiley   +1 more source

Molecular correlates of glycine receptor activity in human β cells. [PDF]

Mol Metab
Schukarucha Gomes A, Ellis CE, Spigelman AF, Dos Santos T, Maghera J, Suzuki K, MacDonald PE.   +6 more
europepmc   +1 more source

Glycine Receptor Subtypes and Their Roles in Nociception and Chronic Pain. [PDF]

Front Mol Neurosci, 2022
San Martín VP, Sazo A, Utreras E, Moraga-Cid G, Yévenes GE.   +4 more
europepmc   +1 more source