Results 151 to 160 of about 1,587,740 (262)

Glycine max "Lee" genome sequencing and assembly

, 2018
The aims of this project were to generate a high-quality reference genome assembly for soybean cultivar "Lee," an important southern cultivar that was released in 1958 and used as a parent in many subsequent southern soybean varieties.
Glycine max cv Lee and Glycine soja PI 483463 sequencing consortium (17856182), SoyBase (17856185), USDA-ARS (17854919)   +2 more
core  

Rhoifolin Alleviates Ulcerative Colitis by Targeting NMNAT1 and Activating SIRT1‐FOXO1 Signaling to Enhance ILC3s Effector Function

Advanced Science, EarlyView.
Rhoifolin directly targets NMNAT1, thereby activating nicotinamide salvage pathway and promoting intracellular NAD+ biosynthesis. Elevated NAD+ levels enhance SIRT1 activity, leading to FOXO1 deacetylation and nuclear translocation. Nuclear FOXO1 subsequently binds to the IL‐22 promoter, upregulating IL‐22 transcription and potentiating ILC3 effector ...
Hongqiong Yang, Yishu Zhang, Sijia Feng, Xiaoqing Ma, Jiayi Feng, Junwei Wang, Jialin Gao, An Pan, Dapeng Wu, Kang Ding, Caijuan Zheng, Qi Lv, Lihong Hu   +12 more
wiley   +1 more source

Breaking symmetry: Homomeric glycine receptor joins the asymmetric gating club. [PDF]

Structure
Wang W.
europepmc   +1 more source

Comprehensive behavioral analyses of mice with a glycine receptor alpha 4 deficiency. [PDF]

Mol Brain, 2023
Darwish M, Hattori S, Nishizono H, Miyakawa T, Yachie N, Takao K.   +5 more
europepmc   +1 more source

Toward Personalized Theranostics: A Modular PET Platform for Antibody‐Based Imaging and Therapy

Advanced Science, EarlyView.
This modular, site‐specific antibody platform enables customizable conjugates for PET imaging and therapy. Interchangeable payloads – including radiometals, cytotoxics, and fluorophores – support adaptable, multimodal applications with limited off‐target effects. In vivo, the DFO/DOTAGA bischelate immunoconjugate provided clear tumor delineation in PET/
Delphine Vivier, Megane Grah Kple, Julen Ariztia, Marion Leroux, Mathieu Moreau, Michael Claron, Maxime Cheveau, Adam Laouafa, Agnieszka Kownacka, Camille Petitot, John Simonet, Alexandre M. M. Dias, Sophie Poty, Charles Truillet, Bertrand Collin, Alexandra Oudot, Franck Denat   +16 more
wiley   +1 more source

Polyclonal glycine receptor aAbs: a challenge for personalized epitope characterization. [PDF]

Front Mol Neurosci
Wiessler AL, Stahl I, Schaefer N, Rauschenberger V, Talucci I, Maric HM, Baykan B, Tüzün E, Sommer C, Villmann C.   +9 more
europepmc   +1 more source

Progressive encephalomyelitis with rigidity and myoclonus (PERM) associated with anti-glycine receptor antibodies and urothelial carcinoma: a case report. [PDF]

J Med Case Rep, 2023
Ali AH, Benterud A, Holmøy T, Myro AZ.
europepmc   +1 more source

Mepce Restrains Ferroptosis in Prostate Cancer Through 7SK–P‐TEFb Pause Control

Advanced Science, EarlyView.
Genome‐wide CRISPR screening identifies MEPCE as a pause‐control regulator that restrains ferroptosis in prostate cancer. MEPCE loss releases P‐TEFb/CDK9 from 7SK snRNP control, enhances RNAPII Ser2 phosphorylation, and accelerates NRF2‐HMOX1‐driven labile iron accumulation and lipid peroxidation, revealing a transcriptional kinetic gate that lowers ...
Tongtong Zhang, Xiangyang Zhan, Jiexiang Zhang, Mingyue Tan, Chuanmin Chu, Guanqun Ju, Xinyu Zhai, Jianyi Gu, Huirong Zhu, Dongliang Xu   +9 more
wiley   +1 more source

Spinal glycine receptor alpha 1 coordinates startle behavior through a cell-type specific mechanism. [PDF]

Int J Biol Sci
Wei S, Xu J, Chen SR, Huang Y, Jarrett Z, Godlewski G, Paloczi J, Pacher P, Pan HL, Xu Y, Lovinger DM, Zhang L.   +11 more
europepmc   +1 more source

Formation of glycine receptor clusters and their accumulation at synapses

, 2000
The glycine receptor is highly enriched in microdomains of the postsynaptic neuronal surface apposed to glycinergic afferent endings. There is substantial evidence suggesting that the selective clustering of glycine receptor at these sites is mediated by
Meunier-Durmort, C., Meier, J., Vannier, C., Forest, C., Triller, A.   +4 more
core