Results 301 to 310 of about 398,460 (354)
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Journal of Neurophysiology, 2005
Glycinergic and GABAergic inhibition are juxtaposed at one retinal synaptic layer yet likely perform different functions. These functions have usually been evaluated using receptor antagonists. In examining retinal glycine receptors, we were surprised to find that commonly used concentrations of GABA antagonists blocked significant fractions of the ...
Peiyuan, Wang, Malcolm M, Slaughter
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Glycinergic and GABAergic inhibition are juxtaposed at one retinal synaptic layer yet likely perform different functions. These functions have usually been evaluated using receptor antagonists. In examining retinal glycine receptors, we were surprised to find that commonly used concentrations of GABA antagonists blocked significant fractions of the ...
Peiyuan, Wang, Malcolm M, Slaughter
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1985
In the vertebrate CNS, many different compounds including acetylcholine, catecholamines, peptides, and amino acids have been identified as bona fide or candidate neurotransmitter substances. Amongst these the amino acids glycine and GABA have been particularly well characterized.
H. Betz +4 more
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In the vertebrate CNS, many different compounds including acetylcholine, catecholamines, peptides, and amino acids have been identified as bona fide or candidate neurotransmitter substances. Amongst these the amino acids glycine and GABA have been particularly well characterized.
H. Betz +4 more
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Glycine binding primes NMDA receptor internalization
Nature, 2003NMDA (N-methyl-d-aspartate) receptors (NMDARs) are a principal subtype of excitatory ligand-gated ion channel with prominent roles in physiological and disease processes in the central nervous system. Recognition that glycine potentiates NMDAR-mediated currents as well as being a requisite co-agonist of the NMDAR subtype of 'glutamate' receptor ...
Nong, Yi +6 more
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Gathering Glycine Receptors at Synapses
Science, 1998Neurons send their signals to the next neuron by shooting neurotransmitters across the intracellular gulf to a cluster of receptors on the downstream neuron. As discussed by Froehner in his Perspective, these receptors are held in place by so-called scaffolding proteins on the inside of the cell. A new example of such proteins is reported on page [1321]
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Hijacking of GABAA Receptors by Mutant Glycine Receptors
Trends in Molecular Medicine, 2019Startle disease results from mutations in genes encoding inhibitory GlyR α1 and β subunits or the presynaptic glycine transporter GlyT2. However, the most effective therapies are benzodiazepines that potentiate inhibitory GABAAR function. A recent publication by Zou et al.
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