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Glycine Receptor Drug Discovery
2017Postsynaptic glycine receptor (GlyR) chloride channels mediate inhibitory neurotransmission in the spinal cord and brain stem, although presynaptic and extrasynaptic GlyRs are expressed more widely throughout the brain. In humans, GlyRs are assembled as homo- or heteromeric pentamers of α1-3 and β subunits. GlyR malfunctions have been linked to a range
Lynch, Joseph W. +3 more
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The inhibitory neuronal glycine receptor
BioEssays, 1994AbstractGlycine is a major inhibitory neurotransmitter in the spinal cord and in the brain stem, where it acts by activating a chloride conductance. The postsynaptic glycine receptor has been purified and contains two transmembrane subunits of 48 kDa (α) and 58 kDa (β), and a peripheral membrane protein of 93 kDa.
C, Béchade, C, Sur, A, Triller
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Journal of Neurophysiology, 2005
Glycinergic and GABAergic inhibition are juxtaposed at one retinal synaptic layer yet likely perform different functions. These functions have usually been evaluated using receptor antagonists. In examining retinal glycine receptors, we were surprised to find that commonly used concentrations of GABA antagonists blocked significant fractions of the ...
Peiyuan, Wang, Malcolm M, Slaughter
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Glycinergic and GABAergic inhibition are juxtaposed at one retinal synaptic layer yet likely perform different functions. These functions have usually been evaluated using receptor antagonists. In examining retinal glycine receptors, we were surprised to find that commonly used concentrations of GABA antagonists blocked significant fractions of the ...
Peiyuan, Wang, Malcolm M, Slaughter
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1985
In the vertebrate CNS, many different compounds including acetylcholine, catecholamines, peptides, and amino acids have been identified as bona fide or candidate neurotransmitter substances. Amongst these the amino acids glycine and GABA have been particularly well characterized.
H. Betz +4 more
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In the vertebrate CNS, many different compounds including acetylcholine, catecholamines, peptides, and amino acids have been identified as bona fide or candidate neurotransmitter substances. Amongst these the amino acids glycine and GABA have been particularly well characterized.
H. Betz +4 more
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Gathering Glycine Receptors at Synapses
Science, 1998Neurons send their signals to the next neuron by shooting neurotransmitters across the intracellular gulf to a cluster of receptors on the downstream neuron. As discussed by Froehner in his Perspective, these receptors are held in place by so-called scaffolding proteins on the inside of the cell. A new example of such proteins is reported on page [1321]
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Hijacking of GABAA Receptors by Mutant Glycine Receptors
Trends in Molecular Medicine, 2019Startle disease results from mutations in genes encoding inhibitory GlyR α1 and β subunits or the presynaptic glycine transporter GlyT2. However, the most effective therapies are benzodiazepines that potentiate inhibitory GABAAR function. A recent publication by Zou et al.
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Sites of alcohol and volatile anaesthetic action on GABAA and glycine receptors
Nature, 1997S. Mihic +13 more
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Structural insights into the inhibition of glycine reuptake
Nature, 2021Azadeh Shahsavar +2 more
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