Ocean acidification affects marine chemical communication by changing structure and function of peptide signalling molecules [PDF]
, 2016 Ocean acidification is a global challenge that faces marine organisms in the near future with a predicted rapid drop in pH of up to 0.4 units by the end of this century.
Adamo +69 more
core +1 more source
Glycine-dependent activation of NMDA receptors
The Journal of General Physiology, 2015 Results from single-molecule and macroscopic electrophysiology and kinetic analysis provide a model for activation of the glutamate-bound NMDA receptor by glycine.
Kirstie A. Cummings, G. Popescu
semanticscholar +1 more source
The E3 ubiquitin ligase IDOL regulates synaptic ApoER2 levels and is important for plasticity and learning. [PDF]
, 2017 Neuronal ApoE receptors are linked to learning and memory, but the pathways governing their abundance, and the mechanisms by which they affect the function of neural circuits are incompletely understood.
Achiro, Jennifer M +9 more
core +3 more sources
Neurotransmitter Specific, Cellular-Resolution Functional Brain Mapping Using Receptor Coated Nanoparticles: Assessment of the Possibility. [PDF]
, 2015 Receptor coated resonant nanoparticles and quantum dots are proposed to provide a cellular-level resolution image of neural activities inside the brain. The functionalized nanoparticles and quantum dots in this approach will selectively bind to different
Forati, Ebrahim +5 more
core +5 more sources
Crosstalk Between Brain-Derived Neurotrophic Factor And N-Methyl-D-Aspartate Receptor Signaling In Neurons [PDF]
, 2008 Glutamate is the major excitatory neurotransmitter in brain exerting prosurvival effect on neurons via N-methyl-D-aspartate receptor (NMDAR) signaling under physiological conditions.
Georgiev, Danko +3 more
core
Gallium labeled NOTA-based conjugates for peptide receptor-mediated medical imaging [PDF]
, 2010 We report a straightforward and efficient synthetic strategy for the synthesis of three model glycine-arginine-glycine-aspartic-glycine (GRGDG) conjugates based on derivatives of NOTA and of their Ga(III) complexes targeted to the integrin αѵβ₃receptor ...
André, João P. +5 more
core +1 more source
Journal of Neuroscience, 2012 Loss-of-function mutations in human glycine receptors cause hyperekplexia, a rare inherited disease associated with an exaggerated startle response. We have studied a human disease mutation in the M2–M3 loop of the glycine receptor α1 subunit (K276E ...
R. Lape +4 more
semanticscholar +1 more source
Regulation of Arabidopsis 14-3-3 gene expression by GABA. [PDF]
, 2006 The function in plants of the non-protein amino acid, gamma-aminobutyric acid (GABA) is poorly understood. In this study, we show that GABA down-regulates the expression of a large sub-set of 14-3-3 gene family members in Arabidopsis thaliana seedlings ...
Lancien, Muriel, Roberts, Michael R
core +1 more source
A Common Molecular Basis for Exogenous and Endogenous Cannabinoid Potentiation of Glycine Receptors
Journal of Neuroscience, 2012 Both exogenous and endogenous cannabinoids can allosterically modulate glycine receptors (GlyRs). However, little is known about the molecular basis of cannabinoid-GlyR interactions.
W. Xiong +3 more
semanticscholar +1 more source
Nature Communications, 2016 Glycine sensing in the dorsal vagal complex (DVC) regulates hepatic glucose production in rodents. Here the authors show that pharmacological and molecular inhibition of glycine reuptake in the DVC potentiates NMDA receptors, and improves metabolic ...
Jessica T. Y. Yue +8 more
doaj +1 more source