Results 91 to 100 of about 4,293 (152)

Precision genome editing:A small revolution for glycobiology

, 2014
Precise and stable gene editing in mammalian cell lines has until recently been hampered by the lack of efficient targeting methods. While different gene silencing strategies have had tremendous impact on many biological fields, they have generally not ...
Vakhrushev, Sergey Y, C. Steentoft, H. Clausen, Bennett, Eric P, H. H. Wandall, S. Y. Vakhrushev, Steentoft, Catharina, E. P. Bennett, Clausen, Henrik, Wandall, Hans H, Schjoldager, Katrine Ter-Borch Gram, K. T.-B. G. Schjoldager   +11 more
core   +1 more source

EUROCarbDB: An open-access platform for glycoinformatics

, 2011
The EUROCarbDB project is a design study for a technical framework, which provides sophisticated, freely accessible, open-source informatics tools and databases to support glycobiology and glycomic research. EUROCarbDB is a relational database containing
Dell, Anne, Blank, Dennis, Damerell, David, von der Lieth, Claus-W., Geyer, Rudolf, Henrick, Kim, Campbell, Matthew P., Hull, William E., Dwek, Raymond A., Freire, Ana Arda, Joshi, Hiren J., Ceroni, Alessio, Frank, Martin, Fogh, Rasmus, Harrison, Mathew J., Ionides, John, Herget, Stephan, Ernst, Beat, et al., Geyer, Hildegard   +19 more
core   +1 more source

Dissecting the Unique Features of Neutrophil Glycobiology in Inflammation and Infection using Glycoanalytics

, 2016
The granulated neutrophils are front-line immune cells critical for the function of the innate immune system. Many aspects of the structure and function of the heterogeneous neutrophil glycoproteome which shows strong subcellularspecific characteristics ...
Packer, Nicolle H, Loke, Ian, Venkatakrishnan, Vignesh, Thaysen-Andersen, Morten   +3 more
core  

Severe attenuation of circadian clock output in the heart following sustained augmentation of cardiomyocyte protein O-GlcNAcylation

Frontiers in Cardiovascular Medicine
BackgroundChanges in circadian-related behaviors (e.g., the timing of food intake, sleep cycles) and the environment (e.g., light-dark cycles) increase the risk of numerous cardiometabolic diseases, including diabetes mellitus and cardiac disease. Recent
Gobinath Shanmugam, Samuel F. Chang, Helen E. Collins, Chae-Myeong Ha, Mariame S. Kane, Luke Potter, Lily Xie, Luyun Zou, Jianhua Zhang, John C. Chatham, Adam R. Wende, Martin E. Young   +11 more
doaj   +1 more source

The minimum information required for a glycomics experiment (MIRAGE) project: improving the standards for reporting glycan microarray-based data

, 2017
MIRAGE (Minimum Information Required for A Glycomics Experiment) is an initiative that was created by experts in the fields of glycobiology, glycoanalytics and glycoinformatics to produce guidelines for reporting results from the diverse types of ...
Dell, Anne, Khoo, Kay-Hooi, Feizi, Ten, Rapp, Erdmann, Costello, Catherine E, Novotny, Milos V, Rudd, Pauline M, Kolarich, Daniel, Smith, David F, Aoki-Kinoshita, Kiyoko F, Kettner, Carsten, Tiemeyer, Michael, York, William S, Ranzinger, Rene, Stoll, Mark, Struwe, Weston B, Paulson, James C, Wells, Lance, Agravat, Sanjay, McBride, Ryan, Karlsson, Niclas G, Liu, Yan, Palma, Angelina S, Silva, Lisete, Packer, Nicolle H, Campbell, Matthew P, Haslam, Stuart M, Zaia, Joseph   +27 more
core   +1 more source

Signal amplification by Glyco-qPCR for ultrasensitive detection of carbohydrates: Applications in glycobiology [PDF]

, 2012
Angewandte Chemie, 51, 11800 –11804Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Dordick, Jonathan S., Masuko, Sayaka, Linhardt, Robert J., Zhang, Fuming, Solakyildirim, Kemal, Li, Lingyun, Ly, Mellisa, Kwon, Seok Joon, Lee, Kyung Bok   +8 more
core   +1 more source

Chemical Approaches to Glycobiology

, 2010
Glycans are ubiquitous components of all organisms. Efforts to elucidate glycan function and to understand how they are assembled and disassembled can reap benefits in fields ranging from bioenergy to human medicine.
Rebecca A. Splain, Laura L. Kiessling
core   +1 more source

The Exploitation of the Glycosylation Pattern in Asthma: How We Alter Ancestral Pathways to Develop New Treatments

Biomolecules
Asthma has reached epidemic levels, yet progress in developing specific therapies is slow. One of the main reasons for this is the fact that asthma is an umbrella term for various distinct subsets.
Angelika Muchowicz, Agnieszka Bartoszewicz, Zbigniew Zaslona   +2 more
doaj   +1 more source

A molecular switch orchestrates enzyme specificity and secretory granule morphology

Nature Communications, 2018
Regulated secretion is an essential process that requires packing and maturation of cargo proteins in membranous secretory granules. Here, authors identify a gene, pgant9, that influences the glycosylation status of the secretory cargo as well as the ...
Suena Ji, Nadine L. Samara, Leslie Revoredo, Liping Zhang, Duy T. Tran, Kayla Muirhead, Lawrence A. Tabak, Kelly G. Ten Hagen   +7 more
doaj   +1 more source

Hot, sweet and sticky: the glycobiology of Plasmodium falciparum

, 2008
Carbohydrate structures that decorate the surface of cells are increasingly recognized as playing important roles in the biology of host-pathogen interactions.
Plebanski, Magdalena, Coppel, Ross L, Cooke, Brian M, von Itzstein, Mark   +3 more
core   +1 more source