Results 1 to 10 of about 24,850 (223)

Checkpoint‐Directed Glycoengineering Reprograms the Vascular Lumen for Siglec‐Mediated Immune Regulation [PDF]

Advanced science
Checkpoint‐directed glycoengineering installs sialylated ligands on the donor vascular lumen during ex vivo preservation, creating a localized Siglec‐7/9‐engaging interface. The engineered glycocalyx suppresses immune‐cell activation, complement deposition, and microvascular injury in arterial and kidney allografts while preserving endothelial ...
Rana M, Rahim J, Bernstein A, Nouri P, Sim L, Enns W, Dumlao J, Luo H, Chafeeva I, Chen H, Wang A, Wang J, Schmidt E, Zhang Z, Cypel M, Nguan C, Macauley M, Withers S, Choy J, Kizhakkedathu J.   +19 more
europepmc   +2 more sources

Preclinical evaluation of multivalent vaccine combinations against Shigella and Salmonella infections [PDF]

Frontiers in Immunology
Shigellosis is an intestinal infection causing severe and often life-threatening diarrheal disease, with high prevalence in children under five years of age in low- and middle-income countries.
Roberta Di Benedetto, Roberta Di Benedetto, Rebecca Nappini, Salvatore Gemmellaro, Federica Boretto, Valentina Caradonna, Martina Carducci, Paola Cescutti, Omar Rossi, Francesca Mancini, Francesco Berlanda Scorza, Simona Rondini, Carlo Giannelli, Renzo Alfini, Francesca Micoli   +14 more
doaj   +2 more sources

Identification and Validation of Glycosyltransferases Correlated with Cuproptosis as a Prognostic Model for Colon Adenocarcinoma

Cells, 2022
Cuproptosis is a newly defined programmed cell death pattern and is believed to play an important role in tumorigenesis and progression. In addition, many studies have shown that glycosylation modification is of vital importance in tumor progression ...
Wei Ma, Lingyuan Zhu, Shushu Song, Bo Liu, Jianxin Gu   +4 more
doaj   +1 more source

Carbohydrate-Containing Low Molecular Weight Metabolites of Microalgae

Marine Drugs, 2023
Microalgae are abundant components of the biosphere rich in low molecular weight carbohydrate-containing natural products (glycoconjugates). Glycoconjugates take part in the processes of photosynthesis, provide producers with important biological ...
Valentin A. Stonik, Inna V. Stonik
doaj   +1 more source

Microbial glycoconjugates in organic pollutant bioremediation: recent advances and applications

Microbial Cell Factories, 2021
The large-scale application of organic pollutants (OPs) has contaminated the air, soil, and water. Persistent OPs enter the food supply chain and create several hazardous effects on living systems. Thus, there is a need to manage the environmental levels
Pankaj Bhatt, Amit Verma, Saurabh Gangola, Geeta Bhandari, Shaohua Chen   +4 more
doaj   +1 more source

Biochemical Characterization of Two Rhamnogalacturonan Lyases From Bacteroides ovatus ATCC 8483 With Preference for RG-I Substrates

Frontiers in Microbiology, 2022
Rhamnogalacturonan lyase (RGL) cleaves backbone α-1,4 glycosidic bonds between L-rhamnose and D-galacturonic acid residues in type I rhamnogalacturonan (RG-I) by β-elimination to generate RG oligosaccharides with various degrees of polymerization.
Weiyang Wang, Yibing Wang, Haoting Yi, Yang Liu, Guojing Zhang, Le Zhang, Kevin H. Mayo, Ye Yuan, Yifa Zhou   +8 more
doaj   +1 more source

Chemical proteomics tracks virus entry and uncovers NCAM1 as Zika virus receptor

Nature Communications, 2020
The mechanism underlying the cellular entry of Zika virus is not fully understood. Here, the authors use a chemically modified virus and time-resolved proteomics to capture interacting host proteins during virus entry and identify NCAM1 as a ZIKV ...
Mayank Srivastava, Ying Zhang, Jian Chen, Devika Sirohi, Andrew Miller, Yang Zhang, Zhilu Chen, Haojie Lu, Jianqing Xu, Richard J. Kuhn, W. Andy Tao   +10 more
doaj   +1 more source

Glutathione disrupts galectin-10 Charcot-Leyden crystal formation to possibly ameliorate eosinophil-based diseases such as asthma

Acta Biochimica et Biophysica Sinica, 2023
Charcot-Leyden crystals (CLCs) are the hallmark of many eosinophilic-based diseases, such as asthma. Here, we report that reduced glutathione (GSH) disrupts CLCs and inhibits crystallization of human galectin-10 (Gal-10).
Na Heya, Sayed Hend, Ayala Gabriela Jaramillo, Wang Xing, Liu Yuhan, Yu Jinyi, Liu Tianhao, Mayo Kevin H., Su Jiyong   +8 more
doaj   +1 more source

Glycoconjugation of Quinoline Derivatives Using the C-6 Position in Sugars as a Strategy for Improving the Selectivity and Cytotoxicity of Functionalized Compounds

Molecules, 2022
Based on the Warburg effect and the increased demand for glucose by tumor cells, a targeted drug delivery strategy was developed. A series of new glycoconjugates with increased ability to interact with GLUT transporters, responsible for the transport of ...
Monika Domińska, Gabriela Pastuch-Gawołek, Magdalena Skonieczna, Wiesław Szeja, Adrian Domiński, Piotr Kurcok   +5 more
doaj   +1 more source

Progress and mechanism of breaking glycoconjugates by glycosidases in skin for promoting unhairing and fiber opening-up in leather manufacture. A review

Journal of Leather Science and Engineering, 2020
The glycoconjugates, herein glyco-proteins, existing in animal skins are closely related to the effectiveness of unhairing and fiber opening-up. Glycosidases have been used in leather making processes to reduce pollutants and improve leather quality. But
Fengxiang Luo, Xiang Zhong, Mengchu Gao, Biyu Peng, Zhongzhen Long   +4 more
doaj   +1 more source