Results 41 to 50 of about 24,850 (223)
Advanced Science, EarlyView.Secreted glycoproteins report on cellular state faster than the cell surface, yet remain hard to measure. The Enzyme‐Linked Cycloaddition Assay (ELCA) combines metabolic azide labeling with click chemistry in an ELISA‐like microplate format, resolving sialylation changes within minutes for 1‐2 EUR per sample.
Jon Lundstrøm +2 more
wiley +1 more source
Loss of GNE Predicts Lymph Node Metastasis in Early Gastric Cancer
Cells, 2022 Endoscopic surgery is increasingly utilized for the treatment of early gastric cancer (EGC) worldwide, whereas lymph node metastasis (LNM) remains a critical risk factor for the relapse of EGC after endoscopic surgery.
Xinying Guo +8 more
doaj +1 more source
pH-sensitive release of antioxidant Se-glycoconjugates through a flexible polymeric patch [PDF]
, 2022 In this work, two novel selenium glycoconjugates are proposed as antioxidants to accelerate skin repair. These molecules, designed with more antioxidant sites and improved healing activity, are composed by a selenosugar covalently linked to a caffeic ...
De Martino S. +7 more
core +1 more source
High-throughput glycosylation screening method for biologics development using MALDI-TOF-MS
Communications ChemistryGlycosylation is a critical quality attribute of therapeutic proteins, yet current analytical methods often fail to meet rapid, high-throughput demands.
Weilong Zhang +4 more
doaj +1 more source
Determining Methyl-Esterification Patterns in Plant-Derived Homogalacturonan Pectins
Frontiers in Nutrition, 2022 Homogalacturonan (HG)-type pectins are nutrient components in plants and are widely used in the food industry. The methyl-esterification pattern is a crucial structural parameter used to assess HG pectins in terms of their nutraceutical activity.
Yang Yu +8 more
doaj +1 more source
The Anatomical Record, EarlyView.Abstract The organization and function of reptilian excurrent ducts remain poorly characterized, particularly in Neotropical snakes. We provide the first integrative morphological, histochemical, immunohistochemical, and ultrastructural analysis of the proximal post‐testicular ducts of Crotalus durissus across reproductive stages.
Flávia Cappuccio de Resende +9 more
wiley +1 more source
Glycoconjugates in host-helminth interactions [PDF]
, 2013 Helminths are multicellular parasitic worms that comprise a major class of human pathogens and cause an immense amount of suffering worldwide. Helminths possess an abundance of complex and unique glycoconjugates that interact with both the innate and ...
Richard D Cummings +6 more
core +1 more source
The Anatomical Record, EarlyView.Histological structure of esophagus. Abstract The aim of this study was to conduct a comparative evaluation of the histological and histochemical organization of the esophagus in two avian species with different feeding ecologies. A total of 6 individuals were used for this purpose (3 storks, 3 common buzzards).
Serap İlhan Aksu +8 more
wiley +1 more source
Anomeric O-Functionalization of Carbohydrates for Chemical Conjugation to Vaccine Constructs
Molecules, 2018 Carbohydrates mediate a wide range of biological interactions, and understanding these processes benefits the development of new therapeutics. Isolating sufficient quantities of glycoconjugates from biological samples remains a significant challenge ...
Simon S. Park +2 more
doaj +1 more source
Chemistry – A European Journal, EarlyView.A set of new phosphonomethyl (thio)phosphonamidite reagents is introduced to generate unprecedented pyrophosphate mimetics. The versatile P(III)‐P(V) reagents allow for the construction of various pyrophosphate isosteres, and the applicability of the chemistry is illustrated in the assembly of a diverse set of stabilized CDP‐glycerol and CDP‐ribitol ...
Pascal Balić +4 more
wiley +1 more source