Results 51 to 60 of about 24,850 (223)

Synthesis of Cholesterol Glycoconjugates for Targeted Liposomal Drug Delivery

, 2020
Herein we describe the synthesis of cholesterol glycoconjugates containing D-glucosyl or D-galactosyl moieties for potential use in targeted liposomal drug delivery to the brain and liver, respectively.
Ferro, Vito, Pan, Yuchen, Al Nahain, Abdullah, Nguyen, Huong, Clarke, Daniel, McMillan, Nigel A   +5 more
core  

Large-scale serum N-glycomics tracks N-glycosylation dynamics in hepatocellular carcinoma progression and enables early diagnosis

Nature Communications
Hepatocellular carcinoma (HCC) is a leading cause of cancer mortality, yet the role of N-glycosylation in its pathogenesis remains unclear. We applied a multi-center, large-cohort N-glycomics strategy combining isomer-specific glycan profiling with multi-
Bin Fu, Jierong Chen, Xuejiao Liu, Jiale Li, Xisong Feng, Jun Wang, Yueyue Li, Yuxiao Zhang, Jianhong Ma, Yunxia Wang, Bing Gu, Ying Zhang, Haojie Lu   +12 more
doaj   +1 more source

Synthesis of α‐C‐Glycoside Conjugates Promoted by 4CzIPN‐Based Porous Organic Polymers Through Giese‐Like Reaction of Glycosyl Bromides in Batch and Continuous Flow

European Journal of Organic Chemistry, EarlyView.
Visible light and a 4CzIPN‐based porous organic polymer (4CzIPN‐POP) enable Giese‐like coupling of glycosyl bromides with electron‐poor alkenes to access α‐C‐glycoside conjugates. The study shows how heterogeneous thermally activated delayed fluorescence photocatalysis can be combined with continuous flow to overcome light penetration limits and ...
Francesco Riina, Laura Manfrin, Lorenzo Poletti, Daniele Ragno, Carmela De Risi, Alessandro Massi, Graziano Di Carmine   +6 more
wiley   +1 more source

The sweet tooth of bacteria : common themes in bacterial glycoconjugates

, 2014
: Humans have been increasingly recognized as being superorganisms, living in close contact with a microbiota on all their mucosal surfaces. However, most studies on the human microbiota have focused on gaining comprehensive insights into the composition
Lebeer, Sarah, Tytgat, Hanne L.P.
core   +1 more source

Mannogalactoglucan from mushrooms protects pancreatic islets via restoring UPR and promotes insulin secretion in T1DM mice

Food Science and Human Wellness
Type 1 diabetes mellitus (T1DM) lacks insulin secretion due to autoimmune deficiency of pancreatic β-cells. Protecting pancreatic islets and enhancing insulin secretion has been therapeutic approaches.
Ting Liu, Si Chen, Yunhe Qu, Lujuan Zheng, Xiaoxuan Yang, Shuhan Men, Yuanning Wang, Hanrui Ma, Yifa Zhou, Yuying Fan   +9 more
doaj   +1 more source

Protective effect of coumarin on cell surface glycoconjugates abnormalities during 7,12-dimethylbenz(a)anthracene (DMBA) induced oral carcinogenesis [PDF]

International Journal of Biological and Medical Research, 2011
Aims: The major aims of the present study was to focus the protective effect of coumarin on cell surface glycoconjugates abnormalities during 7,12-dimethylbenz(a)anthracene (DMBA) induced hamster buccal pouch carcinogenesis. Methods: DMBA painting in the
Nagarethinam Baskaran, Shanmugam Manoharan, Simon Silvan, Duraisamy Palanimuthu,Duraisamy Rajasekaran, Murugaraj Manoj Prabhakar, Sekar Karthikeyan,Ramachandran Srinivasan and Shamsul Afaq Wani   +2 more
doaj  

Subchronic Exposure to Cannabis‐Based Nanoemulsions Induces Histopathological and Molecular Alterations in the Rat Submandibular Gland

Journal of Applied Toxicology, EarlyView.
ABSTRACT The increasing therapeutic incorporation of cannabis has expanded phytocannabinoid application, yet peripheral adverse effects like xerostomia raise concerns regarding emerging biotechnological formulations. This study evaluated the effects of cannabis‐based lipid nanoemulsions on the rat submandibular gland parenchyma.
Lorrany Avanci Bullo, Gabriel Carvalhal de Aguiar, Daniel Vitor Souza, Barbara dos Anjos Rosário, Flavia de Oliveira, Fernando Augusto Cintra Magalhaes, Nágila Maria Pontes Silva Ricardo, Edilberto Rocha Silveira, Dávila Zampieri, Milena de Barros Viana, Daniel Araki Ribeiro   +10 more
wiley   +1 more source

Overview of Glycoconjugate Analysis [PDF]

Current Protocols in Protein Science, 1996
AbstractWhereas DNA, RNA, and proteins are linear polymers that can usually be directly sequenced, glycans show substantially more complexity, having branching and anomeric configurations (α and β linkages). The biosynthesis of glycans, termed glycosylation, is extremely complex, is not template‐driven, varies among different cell types, and cannot be ...
Ajit, Varki, Hudson H, Freeze, Adriana E, Manzi   +2 more
openaire   +3 more sources

Analysis of Carbohydrates and Glycoconjugates by Matrix‐Assisted Laser Desorption/Ionization Mass Spectrometry: An Update for 2023–2024

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The use of MALDI mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this comprehensive review is the twelfth update of the original article published in 1999 and brings coverage of the literature to the end of 2024.
David J. Harvey
wiley   +1 more source

Structural Investigation of the Oligosaccharide Portion Isolated from the Lipooligosaccharide of the Permafrost Psychrophile Psychrobacter arcticus 273-4

Marine Drugs, 2015
Psychrophilic microorganisms have successfully colonized all permanently cold environments from the deep sea to mountain and polar regions. The ability of an organism to survive and grow in cryoenviroments depends on a number of adaptive strategies aimed
Angela Casillo, Ermenegilda Parrilli, Sannino Filomena, Buko Lindner, Rosa Lanzetta, Michelangelo Parrilli, Maria Luisa Tutino, Maria Michela Corsaro   +7 more
doaj   +1 more source