Exploitation of Bacterial N-Linked Glycosylation to Develop a Novel Recombinant Glycoconjugate Vaccine Against Francisella tularensis [PDF]
Open Biology, 2013 Glycoconjugate-based vaccines have proved to be effective at producing long-lasting protection against numerous pathogens. Here, we describe the application of bacterial protein glycan coupling technology (PGCT) to generate a novel recombinant ...
Thomas R Laws +2 more
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Carriers and Antigens: New Developments in Glycoconjugate Vaccines
Vaccines, 2023 Glycoconjugate vaccines have proven their worth in the protection and prevention of infectious diseases. The introduction of the Haemophilus influenzae type b vaccine is the prime example, followed by other glycoconjugate vaccines.
Bernard Metz +2 more
exaly +3 more sources
Recent Advances in the Biosynthesis of Polysaccharide-Based Antimicrobial Glycoconjugate Vaccines
Frontiers in MicrobiologyGlycoconjugate vaccines are a vital category of effective and safe commercial vaccines that have significantly reduced the global prevalence of drug-resistant bacterial infections.
Haining Tan, Yuhan Di
exaly +3 more sources
Impact and Control of Sugar Size in Glycoconjugate Vaccines
Molecules, 2022 Glycoconjugate vaccines have contributed enormously to reducing and controlling encapsulated bacterial infections for over thirty years. Glycoconjugate vaccines are based on a carbohydrate antigen that is covalently linked to a carrier protein; this is ...
Giuseppe Stefanetti +2 more
doaj +1 more source
Synthetic carbohydrate-based vaccines: challenges and opportunities
Journal of Biomedical Science, 2020 Glycoconjugate vaccines based on bacterial capsular polysaccharides (CPS) have been extremely successful in preventing bacterial infections. The glycan antigens for the preparation of CPS based glycoconjugate vaccines are mainly obtained from bacterial ...
Ravinder Mettu +2 more
doaj +1 more source
Glycoconjugates of Mucochloric Acid—Synthesis and Biological Activity
Pharmaceuticals, 2023 The pharmacological effects of the presence of a sugar moiety, 1,2,3-triazole ring and silyl groups in the structure of biologically active compounds have been extensively studied in drug design and medicinal chemistry.
Katarzyna Żurawska +6 more
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Comparison of Shigella GMMA and glycoconjugate four-component formulations in animals
Frontiers in Molecular Biosciences, 2023 Shigellosis is leading bacterial cause of diarrhea with high prevalence in children younger than 5 years in low- and middle-income countries, and increasing number of reports of Shigella cases associated to anti-microbial resistance.
Roberta Di Benedetto +7 more
doaj +1 more source
Saponins of Selected Triterpenoids as Potential Therapeutic Agents: A Review
Pharmaceuticals, 2023 Saponins represent important natural derivatives of plant triterpenoids that are secondary plant metabolites. Saponins, also named glycoconjugates, are available both as natural and synthetic products.
Uladzimir Bildziukevich +2 more
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SEBARAN GLYCOCONJUGATE PADA SEL EPITEL OVIDUK KANCIL (Tragulus javanicus)
Jurnal Kedokteran Hewan, 2015 Penelitian ini bertujuan mengetahui distribusi glycoconjugate yang terekspresi pada sel epitelium oviduk kancil (Tragulus javanicus). Dalam penelitian ini digunakan satu oviduk kancil yang berasal dari satu ekor kancil b etina dewasa berumur lebih ...
Hamny H +6 more
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Distribution of Glycoconjugates in the Gills of Oscar Fish (Astronotus ocellatus)
Süleyman Demirel Üniversitesi Fen-Edebiyat Fakültesi Fen Dergisi, 2021 Glycoconjugates involved in many functions are produced by many cell types. This study aimed to investigate the glycoconjugate expression in the Oscar fish (Astronotus ocellatus) gills using five horseradish peroxidase-conjugated lectins.
Mustafa Öztop +2 more
doaj +1 more source