Results 11 to 20 of about 7,626 (185)

A Synthetic β-Mannan Epitope Enables Immunization and Detection of Candida auris. [PDF]

Angew Chem Int Ed Engl
A synthetic β‐mannan epitope enables both active and passive immunization against Candida auris. Conjugation to the carrier protein CRM197 induces protective antibody responses, while monoclonal antibodies targeting the same epitope support detection using a lateral flow assay, linking glycochemistry with antifungal prevention and diagnostics ...
Reuber EE, Pradhan A, Leaves I, Singh RK, Hickey E, Geiler C, Gow NAR, Brown AJP, Seeberger PH.   +8 more
europepmc   +3 more sources

Critical Roles of O-Acetylation Revealed by Synthetic Trisaccharide Antigens for a Broad-Spectrum Anti-Salmonella Vaccine. [PDF]

Adv Sci (Weinh)
A synthetic glycoconjugate vaccine based on a diacetylated Salmonella trisaccharide elicits broadly protective antibodies against four major human pathogenic serovars. Mechanistic studies identify 2,3‐di‐O‐acetylation of rhamnose as a critical determinant of antigen recognition and breadth of protection, establishing a new strategy for broad‐spectrum ...
Pan X, Maity S, Kavunja H, Murali Y, Chen TA, Huo CX, Baliban SM, Huang X.   +7 more
europepmc   +2 more sources

Generalized Modules for Membrane Antigens as Carrier for Polysaccharides: Impact of Sugar Length, Density, and Attachment Site on the Immune Response Elicited in Animal Models

Frontiers in Immunology, 2021
Nanoparticle systems are being explored for the display of carbohydrate antigens, characterized by multimeric presentation of glycan epitopes and special chemico-physical properties of nano-sized particles.
Francesca Micoli, Renzo Alfini, Roberta Di Benedetto, Francesca Necchi, Fabiola Schiavo, Francesca Mancini, Martina Carducci, Davide Oldrini, Olimpia Pitirollo, Gianmarco Gasperini, Cristiana Balocchi, Nicoletta Bechi, Brunella Brunelli, Diego Piccioli, Roberto Adamo   +14 more
doaj   +1 more source

Checkpoint‐Directed Glycoengineering Reprograms the Vascular Lumen for Siglec‐Mediated Immune Regulation [PDF]

Advanced science
Checkpoint‐directed glycoengineering installs sialylated ligands on the donor vascular lumen during ex vivo preservation, creating a localized Siglec‐7/9‐engaging interface. The engineered glycocalyx suppresses immune‐cell activation, complement deposition, and microvascular injury in arterial and kidney allografts while preserving endothelial ...
Rana M, Rahim J, Bernstein A, Nouri P, Sim L, Enns W, Dumlao J, Luo H, Chafeeva I, Chen H, Wang A, Wang J, Schmidt E, Zhang Z, Cypel M, Nguan C, Macauley M, Withers S, Choy J, Kizhakkedathu J.   +19 more
europepmc   +2 more sources

Immune Response to Conjugates of Fragments of the Type K9 Capsular Polysaccharide of Acinetobacter baumannii with Carrier Proteins

Microbiology Spectrum, 2022
The clonal bacterial species Acinetobacter baumannii is an emerging multidrug-resistant pathogen which causes high-lethality infections. Cells of A. baumannii are surrounded by the type-specific capsular polysaccharide (CPS), which provides resistance to
Natalia Rudenko, Anna Karatovskaya, Anna Zamyatina, Anna Shepelyakovskaya, Svetlana Semushina, Fedor Brovko, Anna Shpirt, Vladimir Torgov, Natalia Kolotyrkina, Alexandr Zinin, Anastasiya Kasimova, Andrei Perepelov, Mikhail Shneider, Yuriy Knirel   +13 more
doaj   +1 more source

Glycoconjugate secretion in human airways in vitro: effects of epithelium removal

Mediators of Inflammation, 1998
The aim of this study was to examine glycoconjugate secretion in human airways with and without an epithelium. Glycoconjugate release in supernatants derived from human airways in vitro was determined using an ELISA assay with an anti-human mucin ...
H. Sossé-Alaoui, C. Labat, I. Gorenne, V. Thomas de Montpreville, J. Bara, C. Brink   +5 more
doaj   +1 more source

Alcohol abuse and glycoconjugate metabolism

Folia Histochemica et Cytobiologica, 2012
The relationship between alcohol consumption and glycoconjugate metabolism is complex and multidimensional. This review summarizes the advances in basic and clinical research on the molecular and cellular events involved in the metabolic effects of ...
Sylwia Chojnowska, Beata Konarzewska, Marzena Wojewódzka-Żelezniakowicz, Alina Minarowska, Agata Szulc, Alina Kępka, Anna Zalewska, Sławomir Dariusz Szajda, Napoleon Waszkiewicz, Jerzy Robert Ładny, Krzysztof Zwierz   +10 more
doaj   +1 more source

Fluorescent glycoconjugates and their applications [PDF]

Chemical Society Reviews, 2020
Fluorescent glycoconjugates are discussed for their applications in biology in vitro , in cell assays and in animal models. Advantages and limitations are presented for each design using a fluorescent core conjugated with glycosides, or vice versa .
Thomas, Baptiste, Yan, Kai-Cheng, Hu, Xi-Le, Donnier-Maréchal, Marion, Chen, Guo-Rong, He, Xiao-Peng, Vidal, Sébastien   +6 more
openaire   +3 more sources

Glycoconjugates: What It Would Take To Master These Well-Known yet Little-Understood Immunogens for Vaccine Development

mSphere, 2019
Glycoconjugate vaccines are a critical component of the medical arsenal against infectious diseases. This established field continues, however, to experience failures in the clinic.
Fikri Avci, Francesco Berti, Peter Dull, John Hennessey, Viliam Pavliak, A. Krishna Prasad, Willie Vann, Michael Wacker, Olivier Marcq   +8 more
doaj   +1 more source

Nucleotide Sugars in Chemistry and Biology

Molecules, 2020
Nucleotide sugars have essential roles in every living creature. They are the building blocks of the biosynthesis of carbohydrates and their conjugates. They are involved in processes that are targets for drug development, and their analogs are potential
Satu Mikkola
doaj   +1 more source