Results 21 to 30 of about 7,626 (185)

Exploring the variables influencing the immune response of traditional and innovative glycoconjugate vaccines

Frontiers in Molecular Biosciences, 2023
Vaccines are cost-effective tools for reducing morbidity and mortality caused by infectious diseases. The rapid evolution of pneumococcal conjugate vaccines, the introduction of tetravalent meningococcal conjugate vaccines, mass vaccination campaigns in ...
Francesca Micoli, Giuseppe Stefanetti, Calman A. MacLennan, Calman A. MacLennan, Calman A. MacLennan   +4 more
doaj   +1 more source

Influence of per-O-sulfation upon the conformational behaviour of common furanosides

Beilstein Journal of Organic Chemistry, 2019
The studies on the recently discovered pyranoside-into-furanoside rearrangement have led us to conformational investigations of furanosides upon their total sulfation.
Alexey G. Gerbst, Vadim B. Krylov, Dmitry A. Argunov, Maksim I. Petruk, Arsenii S. Solovev, Andrey S. Dmitrenok, Nikolay E. Nifantiev   +6 more
doaj   +1 more source

Chemoenzymatic Synthesis of 6‐Sulfo Sialyl Lewisx Containing Glycans to Probe the Receptor Specificity of MERS Coronavirus

Angewandte Chemie, EarlyView.
A chemoenzymatic methodology is described that provided a panel of 6‐sulfo sialyl Lewisx‐containing glycans that were probed for receptor specificity of MERS‐CoV. Although the fucoside of 6‐sulfo‐SLex does not directly interact with the spike, it pre‐organizes the molecule into a conformation to allow a salt bridge between the sulfate and the ...
Yunfei Wu, Anne L.M. Kimpel, Jacobus P. van Trijp, Elif Uslu, Gaёl M. Vos, Luca Unione, Robert P. de Vries, Geert‐Jan Boons   +7 more
wiley   +2 more sources

Theoretical and NMR-based Conformational Analysis of Phosphodiester-linked Disaccharides

Scientific Reports, 2017
The conformational behaviour of three phosphate-bridged dimannosides was studied by means of NMR and computational molecular modelling. First, the conformations of the phosphodiester linker were determined by quantum chemistry methods using dimethyl ...
Alexey G. Gerbst, Andrei V. Nikolaev, Dmitry V. Yashunsky, Alexander S. Shashkov, Andrey S. Dmitrenok, Nikolay E. Nifantiev   +5 more
doaj   +1 more source

Testing a Recombinant Form of Tetanus Toxoid as a Carrier Protein for Glycoconjugate Vaccines

Vaccines, 2023
Glycoconjugate vaccines play a major role in the prevention of infectious diseases worldwide, with significant impact on global health, enabling the polysaccharides to induce immunogenicity in infants and immunological memory.
Davide Oldrini, Roberta Di Benedetto, Martina Carducci, Daniele De Simone, Luisa Massai, Renzo Alfini, Barbara Galli, Brunella Brunelli, Amanda Przedpelski, Joseph T. Barbieri, Omar Rossi, Carlo Giannelli, Rino Rappuoli, Francesco Berti, Francesca Micoli   +14 more
doaj   +1 more source

Synthesis and Anti-Fungal Activity of Seven Oleanolic Acid Glycosides

Molecules, 2011
In order to develop potential anti-fungal agents, seven glycoconjugates composed of a-L-rhamnose, 6-deoxy-a-L-talose, b-D-galactose, a-D-mannose, b-D-xylose-(1®4)-6-deoxy-a-L-talose, b-D-galactose-(1®4)-a-L-rhamnose, b-D-galactose-(1®3)-b-D-xylose-(1®4 ...
Daoquan Wang, Jianjun Zhang, Guanghui Zong, Hanqing Zhao, Xiaomei Liang   +4 more
doaj   +1 more source

GMMA Is a Versatile Platform to Design Effective Multivalent Combination Vaccines

Vaccines, 2020
Technology platforms are an important strategy to facilitate the design, development and implementation of vaccines to combat high-burden diseases that are still a threat for human populations, especially in low- and middle-income countries, and to ...
Francesca Micoli, Renzo Alfini, Roberta Di Benedetto, Francesca Necchi, Fabiola Schiavo, Francesca Mancini, Martina Carducci, Elena Palmieri, Cristiana Balocchi, Gianmarco Gasperini, Brunella Brunelli, Paolo Costantino, Roberto Adamo, Diego Piccioli, Allan Saul   +14 more
doaj   +1 more source

Reinvestigation of Carbohydrate Specificity of EBCA-1 Monoclonal Antibody Used for the Detection of Candida Mannan

Journal of Fungi, 2021
Monoclonal antibody EBCA-1 is used in the sandwich immune assay for the detection of circulating Candida mannan in blood sera samples for the diagnosis of invasive candidiasis.
Vadim B. Krylov, Arsenii S. Solovev, Ilya A. Puchkin, Dmitry V. Yashunsky, Anna V. Antonets, Olga Y. Kutsevalova, Nikolay E. Nifantiev   +6 more
doaj   +1 more source

Recombinant Clostridium difficile Toxin Fragments as Carrier Protein for PSII Surface Polysaccharide Preserve Their Neutralizing Activity

Toxins, 2014
Clostridium difficile is a Gram-positive bacterium and is the most commonly diagnosed cause of hospital-associated and antimicrobial-associated diarrhea. Despite the emergence of epidemic C. difficile strains having led to an increase in the incidence of
Maria R. Romano, Rosanna Leuzzi, Emilia Cappelletti, Marta Tontini, Alberto Nilo, Daniela Proietti, Francesco Berti, Paolo Costantino, Roberto Adamo, Maria Scarselli   +9 more
doaj   +1 more source

Advances in Bacterial Oligosaccharyltransferase Structure Elucidation and Potential Application to Glycoconjugate Vaccine Design

Frontiers in Bioscience-Landmark, 2023
Glycosylation is one of the most common post-translational modifications of proteins across all kingdoms of life. Diverse monosaccharides and polysaccharides can be attached to a range of amino acid residues generating N-glycosylation, O-glycosylation, C-
Riye Lu, Pengwei Li, Li Zhu, Ming Xian Chang, Songying Ouyang   +4 more
doaj   +1 more source