Results 1 to 10 of about 1,222 (163)

Testing S. sonnei GMMA with and without Aluminium Salt-Based Adjuvants in Animal Models [PDF]

Pharmaceutics
Shigellosis is one of the leading causes of diarrheal disease in low- and middle-income countries, particularly in young children, and is more often associated with antimicrobial resistance.
Francesca Mancini, Valentina Caradonna, Renzo Alfini, Maria Grazia Aruta, Claudia Giorgina Vitali, Gianmarco Gasperini, Diego Piccioli, Francesco Berlanda Scorza, Omar Rossi, Francesca Micoli   +9 more
doaj   +6 more sources

Comparison of Shigella GMMA and glycoconjugate four-component formulations in animals [PDF]

Frontiers in Molecular Biosciences, 2023
Shigellosis is leading bacterial cause of diarrhea with high prevalence in children younger than 5 years in low- and middle-income countries, and increasing number of reports of Shigella cases associated to anti-microbial resistance.
Roberta Di Benedetto, Roberta Di Benedetto, Francesca Mancini, Valentina Caradonna, Maria Grazia Aruta, Carlo Giannelli, Omar Rossi, Francesca Micoli   +7 more
doaj   +7 more sources

GMMA-Based Vaccines: The Known and the Unknown [PDF]

Frontiers in Immunology, 2021
Generalized Modules for Membrane Antigens (GMMA) are outer membrane vesicles derived from Gram-negative bacteria engineered to provide an over-vesiculating phenotype, which represent an attractive platform for the design of affordable vaccines.
Francesca Micoli, Omar Rossi, Mariagrazia Pizza   +2 more
exaly   +6 more sources

Enhanced Systemic Humoral Immune Response Induced in Mice by Generalized Modules for Membrane Antigens (GMMA) Is Associated With Affinity Maturation and Isotype Switching

Vaccines, 2023
Generalized Modules for Membrane Antigens (GMMA) are outer membrane vesicles derived from Gram-negative bacteria that can be used to design affordable subunit vaccines. GMMA have been observed to induce a potent humoral immune response in preclinical and
Diego Piccioli, Renzo Alfini, Silvana Savino   +2 more
exaly   +5 more sources

Salmonella Vaccine Study in Oxford (SALVO) trial: protocol for an observer-participant blind randomised placebo-controlled trial of the iNTS-GMMA vaccine within a European cohort [PDF]

BMJ Open, 2023
Introduction Invasive non-typhoidal Salmonellosis (iNTS) is mainly caused by Salmonella enterica serovars Typhimurium and Enteritidis and is estimated to result in 77 500 deaths per year, disproportionately affecting children under 5 years of age in sub ...
, Melita A Gordon, Ellis Owusu-Dabo, Florian Marks, Carsten Mantel, Andrew J Pollard, Brama Hanumunthadu, Rachel White, John A Crump, Hannah Robinson, Jan Jacobs, Samuel Kariuki, Bieke Tack, Stefano Malvolti, Nasir Kanji, Nelly Owino, Carla Ferreira Da Silva, Pietro Ferruzzi, Usman Nakakana, Rocio Canals, Maheshi Ramasamy, Francis Agyapong, Gianluca Breghi, Fabio Fiorino, Christian S. Marchello, Donata Medaglini, Esther M. Muthumbi, Chisomo L. Msefula, Tonney S. Nyirenda, Robert Onsare, Elena Pettini, Anthony G Scott J, Bassiahi Abdramane Soura, Tiziana Spadafina   +33 more
doaj   +5 more sources

Development of a GMMA-based candidate vaccine against invasive nontyphoidal Salmonella disease [PDF]

Frontiers in Immunology
IntroductionInvasive nontyphoidal Salmonella (iNTS) disease is one of the most common causes of bacteremia in sub-Saharan Africa (sSA), mostly affecting children less than 5 years of age and with an associated 14.7% case fatality ratio.
Francesco Citiulo, Oliver Koeberling, Oliver Koeberling, Omar Rossi, Emilia Cappelletti, Carlo Giannelli, Maria Grazia Aruta, Daniele De Simone, Federico Pippi, Xhenti Ferhati, Antonia De Felice, Alessandra Acquaviva, Angela Daniele, Filomena De Luca, Giulia Iannello, Claudia G. Vitali, Francesca Necchi, Laura B. Martin, Laura B. Martin, Francesco Berlanda Scorza, Francesco Berlanda Scorza, Anna Maria Colucci, Rocío Canals, Rocío Canals   +23 more
doaj   +4 more sources

GMMA-based vaccine candidates against invasive nontyphoidal salmonellosis elicit bactericidal antibodies against a panel of epidemiologically relevant Salmonellae [PDF]

Frontiers in Immunology
Systemic disease caused by nontyphoidal Salmonella (NTS) represents a major cause of death and morbidity, especially in young children in sub-Saharan Africa.
Daniele De Simone, Marika Pinto, Maria Grazia Aruta, Marta Benincasa, Martina Carducci, Roberta Di Benedetto, Francesco Citiulo, Miren Iturriza, Elli Mylona, Stephen Baker, Mariagrazia Pizza, Carlo Giannelli, Francesca Mancini, Rocío Canals, Omar Rossi   +14 more
doaj   +8 more sources

Generalized Modules for Membrane Antigens (GMMA) Elicit Mild Local Reactogenicity After Intramuscular Injection in Absence of Aluminum Salt Adjuvant [PDF]

Immunity, Inflammation and Disease
Background and Objectives Generalized modules for membrane antigens (GMMA) are outer membrane vesicles derived from gram‐negative bacteria that can be used to design affordable subunit vaccines.
Raffaella Cecchi, Silvia Maccari, Renzo Alfini, Roberta Di Benedetto, Simona Gallorini, Elena Cartocci, Sara Marchi, Giacomo Romagnoli, Erika Bartolini, Francesca Micoli, Diego Piccioli   +10 more
doaj   +3 more sources

GMMA as adjuvant and carrier for mucosal delivery of group A streptococcus glycoconjugate vaccine [PDF]

Human Vaccines & Immunotherapeutics
Group A streptococcus (GAS) infection is usually initiated by colonization of mucosal sites such as the pharynx, followed by invasion and systemic dissemination.
James Ozanne, Manolya Saydam, Elena Palmieri, Roberta Di Benedetto, Anjum Aktar, Martina Carducci, Luca Rovetini, Omar Rossi, H. Alexandra Shaw, Francesca Micoli, Fatme Mawas   +10 more
doaj   +3 more sources

Safety and immunogenicity of the invasive non-typhoidal Salmonella (iNTS)-GMMA vaccine: a first-in-human, randomised, dose escalation trialResearch in context [PDF]

EBioMedicine
Summary: Background: Invasive non-typhoid Salmonella (iNTS) is a leading cause of morbidity and mortality in sub-Saharan Africa. We assess the safety and immunogenicity of an outer membrane vesicle vaccine (iNTS-GMMA) derived from the two most common ...
Brama Hanumunthadu, Tesfaye Demissie, Melanie Greenland, Peter Skidmore, Kiarash Tanha, Tim Crocker-Buque, Nelly Owino, Antonella Silvia Sciré, Chiara Crispino, Daniele De Simone, Marta Benincasa, Maria Grazia Aruta, Omar Rossi, Anna Maria Colucci, Francesco Berlanda Scorza, Ashwani Kumar Arora, Xinxue Liu, Elizabeth A. Clutterbuck, Leila Godfrey, Rocio Canals, Maheshi N. Ramasamy, Francis Agyapong, Gianluca Breghi, Annalisa Ciabattini, John A. Crump, Melita A. Gordon, Liselotte Hardy, Samuel Kariuki, Stefano Malvolti, Carsten Mantel, Christian S. Marchello, Florian Marks, Donata Medaglini, Tonney S. Nyirenda, Mercy Ngetich, Ellis Owusu-Dabo, Francesco Santoro, J. Anthony G. Scott, Bassiahi Abdramane Soura, Tiziana Spadafina, Bieke Tack   +40 more
doaj   +3 more sources