Results 21 to 30 of about 1,222 (163)

Development of a Promising Bivalent Vaccine Against Klebsiella pneumoniae Based on Glycoengineered GMMA (geGMMA) [PDF]

Exploration
Multidrug‐resistant Klebsiella pneumoniae constitutes a significant threat as a nosocomial pathogen, and no licensed vaccines are currently available. Generalized modules for membrane antigens (GMMA) have recently been recognized as a promising platform ...
Jingqin Ye, Wenhua Huang, Shujuan Yu, Yan Guo, Peng Sun, Ziyuan Chen, Linhui Hao, Yan Zhang, Caixia Li, Yongqiang Jiang, Jun Wu, Li Zhu, Hengliang Wang, Chao Pan   +13 more
doaj   +5 more sources

Novel Simple Conjugation Chemistries for Decoration of GMMA With Heterologous Antigens [PDF]

International Journal of Molecular Sciences, 2021
Outer Membrane Vesicles (OMV) constitute a promising platform for the development of efficient vaccines. OMV can be decorated with heterologous antigens (proteins or polysaccharides), becoming attractive novel carriers for the development of ...
Martina Carducci, Francesca Micoli, Elena Palmieri   +2 more
exaly   +5 more sources

GMMA decorated with mucin 1 Tn/STn mimetics elicit specific antibodies response and inhibit tumor growth [PDF]

npj Vaccines
Carbohydrate-based therapeutic vaccines are actively pursued as targeted immunotherapy to treat cancer. Aberrant glycosylation is indeed of paramount importance in tumors, leading to the formation of “neo-epitopes”, known as tumor-associated carbohydrate
Elisa Pesce, Andrea Sodini, Elena Palmieri, Silvia Valensin, Cristina Tinti, Marco Rossi, Antonella De Rosa, Marco Fragai, Francesco Papi, Chiara Cordiglieri, Francesco Berti, Renata Grifantini, Francesca Micoli, Cristina Nativi   +13 more
doaj   +6 more sources

GMMA Can Stabilize Proteins Across Different Functional Constraints

Journal of Molecular Biology
Stabilizing proteins without otherwise hampering their function is a central task in protein engineering and design. PYR1 is a plant hormone receptor that has been engineered to bind diverse small molecule ligands.
Kristoffer E Johansson, Ian R Wheeldon, Kresten Lindorff-Larsen   +2 more
exaly   +6 more sources

Evaluation of cross-functional antibody responses elicited by a four-component GMMA Shigella vaccine. [PDF]

NPJ Vaccines
Shigella is a major cause of morbidity and mortality in children in low- and middle-income countries. The O-antigen (OAg) component of the lipopolysaccharide is considered a protective antigen, however, their diversity challenges vaccine development ...
Caradonna V, Sarakinou E, Di Benedetto R, Hunyady A, Nakakana U, Alfini R, Pinto M, Boretto F, Gemmellaro S, Ferruzzi P, Iturriza M, Berlanda Scorza F, Rondini S, Conti V, Giannelli C, Arora AK, Rossi O, Micoli F, Mancini F.   +18 more
europepmc   +4 more sources

Towards a Four-Component GMMA-Based Vaccine Against Shigella [PDF]

Vaccines, 2022
Shigellosis remains a major public health problem around the world; it is one of the leading causes of diarrhoeal disease in low- and middle-income countries, particularly in young children.
Francesca Micoli, Usman Nasir Nakakana, Francesco Berlanda Scorza   +2 more
exaly   +5 more sources

Generalized Modules for Membrane Antigens (GMMA), an outer membrane vesicle‐based vaccine platform, for efficient viral antigen delivery [PDF]

Journal of Extracellular Vesicles, 2022
Vaccine platforms enable fast development, testing, and manufacture of more affordable vaccines. Here, we evaluated Generalized Modules for Membrane Antigens (GMMA), outer membrane vesicles (OMVs) generated by genetically modified Gram‐negative bacteria,
Kai Hu, Elena Palmieri, Karnyart Samnuan, Beatrice Ricchetti, Davide Oldrini, Paul F. McKay, Guanghui Wu, Leigh Thorne, Anthony R. Fooks, Lorraine M. McElhinney, Hooman Goharriz, Megan Golding, Robin J. Shattock, Francesca Micoli   +13 more
doaj   +3 more sources

Protein-specific immune response elicited by the Shigella sonnei 1790GAHB GMMA-based candidate vaccine in adults with varying exposure to Shigella [PDF]

mSphere
Shigella is a leading cause of diarrheal morbidity and mortality in young children from low- and middle-income countries. Here, we aimed to verify the ability of the generalized modules for membrane antigens (GMMA)-based Shigella sonnei candidate vaccine
Arlo Z. Randall, Valentino Conti, Usman Nakakana, Xiaowu Liang, Andy A. Teng, Antonio Lorenzo Di Pasquale, Melissa Kapulu, Robert Frenck, Odile Launay, Pietro Ferruzzi, Antonella Silvia Sciré, Elisa Marchetti, Christina Obiero, Jozelyn V. Pablo, Joshua Edgar, Philip Bejon, Adam D. Shandling, Joseph J. Campo, Angela Yee, Laura B. Martin, Audino Podda, Francesca Micoli   +21 more
doaj   +3 more sources

Dissecting the contribution of O-Antigen and proteins to the immunogenicity of Shigella sonnei generalized modules for membrane antigens (GMMA) [PDF]

Scientific Reports, 2021
GMMA are exosomes released from engineered Gram-negative bacteria resembling the composition of outer membranes. We applied the GMMA technology for the development of an O-Antigen (OAg) based vaccine against Shigella sonnei, the most epidemiologically ...
Francesca Mancini, Gianmarco Gasperini, Omar Rossi, Maria Grazia Aruta, Maria Michelina Raso, Renzo Alfini, Massimiliano Biagini, Francesca Necchi, Francesca Micoli   +8 more
doaj   +4 more sources

Contribution of the different Neisseria gonorrhoeae lipooligosaccharide structural variants to functional responses elicited by GMMA outer membrane vesicles. [PDF]

NPJ Vaccines
Despite decades of research, an effective vaccine against Neisseria gonorrhoeae remains elusive due to the pathogen's antigenic variability and immune evasion capabilities.
Cuffaro R, Buffi G, Romagnoli G, Giuliani M, Proietti D, Zambelli M, Spinsanti M, Manetti AGO, Fabbrini M, Savino S, Giordano G, Delany I, Bartolini E, Ram S, Romano MR, Margarit I, Carboni F.   +16 more
europepmc   +4 more sources