GMMA Is a Versatile Platform to Design Effective Multivalent Combination Vaccines [PDF]
Vaccines, 2020 Technology platforms are an important strategy to facilitate the design, development and implementation of vaccines to combat high-burden diseases that are still a threat for human populations, especially in low- and middle-income countries, and to ...
Roberto Adamo +2 more
exaly +7 more sources
Dissecting in Vitro the Activation of Human Immune Response Induced by Shigella sonnei GMMA [PDF]
Frontiers in Cellular and Infection Microbiology, 2022 Generalized Modules for Membrane Antigens (GMMA) are outer membrane exosomes purified from Gram-negative bacteria genetically mutated to increase blebbing and reduce risk of reactogenicity.
Francesca Micoli +2 more
exaly +10 more sources
Exploring the Role of GMMA Components in the Immunogenicity of a 4-Valent Vaccine Against Shigella
International Journal of Molecular Sciences, 2023 Shigellosis is the leading cause of diarrheal disease, especially in children of low- and middle-income countries, and is often associated with anti-microbial resistance.
Martina Carducci +2 more
exaly +5 more sources
GMMA as an Alternative Carrier for a Glycoconjugate Vaccine against Group A Streptococcus [PDF]
Vaccines, 2022 Group A Streptococcus (GAS) causes about 500,000 annual deaths globally, and no vaccines are currently available. The Group A Carbohydrate (GAC), conserved across all GAS serotypes, conjugated to an appropriate carrier protein, represents a promising ...
Elena Palmieri +14 more
doaj +8 more sources
Exploration of a GMMA-Based Bivalent Vaccine Against Klebsiella pneumoniae [PDF]
VaccinesBackground: An emerging trend of mutual convergence between drug-resistant and highly virulent strains of K. pneumoniae has been identified, highlighting the urgent need for the development of novel vaccines.
Qikun Ou +9 more
doaj +5 more sources
A novel GMMA-based gonococcal vaccine demonstrates functional immune responses in mice [PDF]
npj VaccinesGonorrhea, caused by Neisseria gonorrhoeae (GC) represents a significant public health threat that may be mitigated by an effective vaccine. Vaccines containing N.
Marco Spinsanti +34 more
doaj +5 more sources
GMMA as delivery system for Klebsiella pneumoniae O-antigens and K-antigens [PDF]
Scientific ReportsKlebsiella pneumoniae (Kp) is a major cause of healthcare-associated infections in developed countries and neonatal sepsis in low- and middle-income countries, posing a global public health threat due to its antimicrobial resistance.
Maria Michelina Raso +14 more
doaj +4 more sources
A next-generation GMMA-based vaccine candidate to fight shigellosis [PDF]
npj Vaccines, 2023 Shigellosis is a leading cause of diarrheal disease in low-middle-income countries (LMICs). Effective vaccines will help to reduce the disease burden, exacerbated by increasing antibiotic resistance, in the most susceptible population represented by ...
Omar Rossi +18 more
doaj +5 more sources
Effect of O-Antigen Chain Length Regulation on the Immunogenicity of Shigella and Salmonella Generalized Modules for Membrane Antigens (GMMA) [PDF]
International Journal of Molecular Sciences, 2021 Recently, generalized modules for membrane antigens (GMMA) technology has been proposed as an alternative approach to traditional glycoconjugate vaccines for O-antigen delivery.
Gianmarco Gasperini +2 more
exaly +8 more sources
Rapid generation of Shigella flexneri GMMA displaying natural or new and cross-reactive O-Antigens [PDF]
npj Vaccines, 2022 Generalized modules for membrane antigens (GMMA) are exosomes released from engineered Gram-negative bacteria and represent an attractive vaccine platform for the delivery of the O-Antigen (OAg), recognized as the key target for protective immunity ...
Gianmarco Gasperini +9 more
doaj +6 more sources