Classical and Novel Strategies to Develop a Shigella Glycoconjugate Vaccine: From Concept to Efficacy in Human [PDF]
Human Vaccines and Immunotherapeutics, 2019 Shigella are gram-negative bacteria that cause severe diarrhea and dysentery, with a high level of antimicrobial resistance. Disease-induced protection against reinfection in Shigella-endemic areas provides convincing evidence on the feasibility of a ...
Laurence A Mulard, Louis-Antoine Barel
exaly +3 more sources
Potentiating pneumococcal glycoconjugate vaccine PCV13 with saponin adjuvant VSA-1 [PDF]
Frontiers in Immunology, 2022 VSA-1 is a semisynthetic saponin adjuvant prepared from naturally occurring Momordica saponin and capable of stimulating antigen-specific humoral and cellular immune responses.
Hyunjung Kim +5 more
doaj +2 more sources
Recent and Future Advances in the Chemoenzymatic Synthesis of Homogeneous Glycans for Bacterial Glycoconjugate Vaccine Development [PDF]
Vaccines, 2021 Vaccines are important in preventing disease outbreaks and controlling the spread of disease in a population. A variety of vaccines exist, including subunit, recombinant, and conjugate vaccines.
Ayobami Adegbite, Pumtiwitt C. McCarthy
doaj +2 more sources
Progress towards a glycoconjugate vaccine against Group A Streptococcus [PDF]
npj Vaccines, 2023 The Group A Carbohydrate (GAC) is a defining feature of Group A Streptococcus (Strep A) or Streptococcus pyogenes. It is a conserved and simple polysaccharide, comprising a rhamnose backbone and GlcNAc side chains, further decorated with glycerol ...
Keira Burns +4 more
doaj +2 more sources
Exploitation of Bacterial N-Linked Glycosylation to Develop a Novel Recombinant Glycoconjugate Vaccine Against Francisella tularensis [PDF]
Open Biology, 2013 Glycoconjugate-based vaccines have proved to be effective at producing long-lasting protection against numerous pathogens. Here, we describe the application of bacterial protein glycan coupling technology (PGCT) to generate a novel recombinant ...
Thomas R Laws +2 more
exaly +2 more sources
Carriers and Antigens: New Developments in Glycoconjugate Vaccines
Vaccines, 2023 Glycoconjugate vaccines have proven their worth in the protection and prevention of infectious diseases. The introduction of the Haemophilus influenzae type b vaccine is the prime example, followed by other glycoconjugate vaccines.
Bernard Metz +2 more
exaly +3 more sources
Evaluation of a FlpA Glycoconjugate Vaccine with Ten N-Heptasaccharide Glycan Moieties to reduce Campylobacter jejuni Colonisation in Chickens [PDF]
VaccinesCampylobacter is a major cause of acute gastroenteritis in humans, and infections can be followed by inflammatory neuropathies and other sequelae. Handling or consumption of poultry meat is the primary risk factor for human campylobacteriosis, and C ...
Ricardo Corona-Torres +9 more
doaj +2 more sources
Site-Specific Conjugation for Fully Controlled Glycoconjugate Vaccine Preparation [PDF]
Frontiers in Chemistry, 2019 Glycoconjugate vaccines are formed by covalently link a carbohydrate antigen to a carrier protein whose role is to achieve a long lasting immune response directed against the carbohydrate antigen.
Aline Pillot +12 more
doaj +2 more sources
Immunogenicity Assessment of Different Segments and Domains of Group A Streptococcal C5a Peptidase and Their Application Potential as Carrier Protein for Glycoconjugate Vaccine Development [PDF]
Vaccines, 2021 Group A streptococcal C5a peptidase (ScpA) is a highly conserved surface virulence factor present on group A streptococcus (GAS) cell surfaces. It has attracted much more attention as a promising antigenic target for GAS vaccine development due to its ...
Guirong Wang +5 more
doaj +2 more sources
A candidate glycoconjugate vaccine induces protective antibodies in the serum and intestinal secretions, antibody recall response and memory T cells and protects against both typhoidal and non-typhoidal Salmonella serovars [PDF]
Frontiers in Immunology, 2023 Human Salmonella infections pose significant public health challenges globally, primarily due to low diagnostic yield of systemic infections, emerging and expanding antibiotic resistance of both the typhoidal and non-typhoidal Salmonella strains and the ...
Risha Haldar +8 more
doaj +2 more sources