Results 41 to 50 of about 2,336 (164)

A Novel Shigella O-Polysaccharide–IpaB Conjugate Vaccine Elicits Robust Antibody Responses and Confers Protection against Multiple Shigella Serotypes

mSphere, 2023
Shigella is responsible for high burdens of diarrhea and dysentery globally. Children living in areas of endemicity are the most affected, and currently, there are no licensed vaccines to prevent shigellosis.
Girmay Desalegn, Neeraj Kapoor, Lucy Pill-Pepe, Leslie Bautista, Lu Yin, Esther Ndungo, Edwin V. Oaks, Jeff Fairman, Marcela F. Pasetti   +8 more
doaj   +1 more source

Meningococcal Vaccines: Current Status and Emerging Strategies

Vaccines, 2018
Neisseria meningitidis causes most cases of bacterial meningitis. Meningococcal meningitis is a public health burden to both developed and developing countries throughout the world.
Pumtiwitt C. McCarthy, Abeer Sharyan, Laleh Sheikhi Moghaddam   +2 more
doaj   +1 more source

Calibration of a serum reference standard for Group B streptococcal polysaccharide conjugate vaccine development using surface plasmon resonance

npj Vaccines, 2023
Group B streptococcus (GBS) is a leading cause of neonatal morbidity and mortality worldwide. Development of a maternal vaccine to protect newborns through placentally transferred antibody is considered feasible based on the well-established relationship
Alexandre Esadze, Christopher D. Grube, Sabine Wellnitz, Suddham Singh, Ha H. Nguyen, Michelle A. Gaylord, Aiping Zhu, Alexey Gribenko, Charles Y. Tan, Annaliesa S. Anderson, Raphael Simon   +10 more
doaj   +1 more source

Impact and Control of Sugar Size in Glycoconjugate Vaccines

Molecules, 2022
Glycoconjugate vaccines have contributed enormously to reducing and controlling encapsulated bacterial infections for over thirty years. Glycoconjugate vaccines are based on a carbohydrate antigen that is covalently linked to a carrier protein; this is necessary to cause T cell responses for optimal immunogenicity, and to protect young children.
Stefanetti, Giuseppe, MacLennan, Calman Alexander, Micoli, Francesca   +2 more
openaire   +4 more sources

Role of Extracellular Vesicles in Shaping Immune Responses in the Lymph Node Microenvironment

Biology of the Cell, Volume 118, Issue 10, October 2026.
Functional alliances of stromal, innate and adaptive immune cells in EV immunity in the lymph node. EV reflect the phenotype of their mother cell and cluster material from their surroundings. In the lymph node, EV preserve valuable context information between multiple cellular effectors to coordinate immunity in adaption to change.
Alicia Charrier, Apolline Salama, Laurence Dubreil, Grégoire Mignot, Steffi Bosch   +4 more
wiley   +1 more source

Glycoconjugate vaccines and immune interactions, and implications for vaccination schedules

Expert Review of Vaccines, 2011
Conjugate vaccines using diphtheria toxoid variant (CRM(197)), diphtheria toxoid and tetanus toxoid (TT) as carrier protein may induce immune interactions (interference or impairment as measured by lower antibody levels, or enhancement [higher antibody levels]) when coadministered with other vaccines.
Ray, Borrow, Ron, Dagan, Fred, Zepp, Hans, Hallander, Jan, Poolman   +4 more
openaire   +2 more sources

Synthetic O‐Polysaccharide Backbone Units for a Single Antigen Vaccine Against Two Major Non‐Typhoidal Salmonella Serovars

Angewandte Chemie, Volume 138, Issue 26, 22 June 2026.
A modular strategy was developed to synthesize tri‐, hexa‐, and nona‐saccharides representing repeating units of the conserved O‐polysaccharide backbone of Salmonella. Conjugates of these glycans to bacteriophage Qβ induced strong IgG responses in mice and rabbits. Antibodies elicited recognized native O‐polysaccharides and conferred protection against
Xingling Pan, Changxin Huo, Soham Maity, Herbert Kavunja, Rachel Moszyk, Cameron Talbot, Scott M. Baliban, Xuefei Huang   +7 more
wiley   +2 more sources

Glycoconjugate vaccines: current approaches towards faster vaccine design [PDF]

Expert Review of Vaccines, 2019
Introduction: Over the last decades, glycoconjugate vaccines have been proven to be a successful strategy to prevent infectious diseases. Many diseases remain to be controlled, especially in developing countries, and emerging antibiotic-resistant bacteria present an alarming public-health threat.
Micoli, Francesca, Del Bino, Linda, Alfini, Renzo, Carboni, Filippo, Romano, Maria Rosaria, Adamo, Roberto   +5 more
openaire   +2 more sources

Cancer cells and viruses share common glycoepitopes: exciting opportunities toward combined treatments

Frontiers in Immunology
Aberrant glycosylation patterns of glycoproteins and glycolipids have long been recognized as one the major hallmarks of cancer cells that has led to numerous glycoconjugate vaccine attempts.
René Roy
doaj   +1 more source

A Chemically Defined Four‐Component Self‐Adjuvanting Tn Vaccine Activating Mincle, FcγR, and CD206 for Enhanced Antitumor Immunity

Advanced Science, Volume 13, Issue 52, 18 September 2026.
A fully synthetic four‐component vaccine has been developed combining Tn antigen, vizantin (Mincle agonist), rhamnose (antibody recruitment), and mannose (CD206 targeting). By synergistically activating Mincle, FcγR, and CD206 pathways, it elicits strong IgG switching and cytotoxic T‐cells, significantly inhibiting tumors in mice.
Wenbo Ming, Renyu Zhang, Xiaohui Li, Guiqi Li, Yu Niu, Deying Yang, Xiang Luo, Jun Liao, Zhongqiu Liu, Guochao Liao   +9 more
wiley   +1 more source