Results 51 to 60 of about 2,336 (164)

Recombinant production platform for Group A Streptococcus glycoconjugate vaccines

npj Vaccines
Group A Streptococcus (Strep A) is a human-exclusive bacterial pathogen killing annually more than 500,000 patients, and no current licensed vaccine exists.
Sowmya Ajay Castro, Ian J. Passmore, Didier Ndeh, Helen Alexandra Shaw, Alessandro Ruda, Keira Burns, Sarah Thomson, Rupa Nagar, Kathirvel Alagesan, Mark Reglinski, Kieron Lucas, Sherif Abouelhadid, Ulrich Schwarz-Linek, Fatme Mawas, Göran Widmalm, Brendan W. Wren, Helge C. Dorfmueller   +16 more
doaj   +1 more source

Development of a glycoconjugate vaccine to prevent invasive Salmonella Typhimurium infections in sub-Saharan Africa.

PLoS Neglected Tropical Diseases, 2017
Invasive infections associated with non-typhoidal Salmonella (NTS) serovars Enteritidis (SE), Typhimurium (STm) and monophasic variant 1,4,[5],12:i:- are a major health problem in infants and young children in sub-Saharan Africa, and currently, there are
Scott M Baliban, Mingjun Yang, Girish Ramachandran, Brittany Curtis, Surekha Shridhar, Rachel S Laufer, Jin Y Wang, John Van Druff, Ellen E Higginson, Nicolas Hegerle, Kristen M Varney, James E Galen, Sharon M Tennant, Andrew Lees, Alexander D MacKerell, Myron M Levine, Raphael Simon   +16 more
doaj   +1 more source

Modification of avian pathogenic Escherichia coli χ7122 lipopolysaccharide increases accessibility to glycoconjugate antigens

Microbial Cell Factories, 2022
Background Worldwide, an estimated 70.7 billion broilers were produced in 2020. With the reduction in use of prophylactic antibiotics as a result of consumer pressure and regulatory oversight alternative approaches, such as vaccination, are required to ...
Alexander A. Smith, Ricardo Corona-Torres, Rachel E. Hewitt, Mark P. Stevens, Andrew J. Grant, the Glycoengineering of Veterinary Vaccines Consortium   +5 more
doaj   +1 more source

Recent advances in the production of recombinant glycoconjugate vaccines [PDF]

npj Vaccines, 2019
AbstractGlycoconjugate vaccines against bacteria are one of the success stories of modern medicine and have led to a significant reduction in the global occurrence of bacterial meningitis and pneumonia. Glycoconjugate vaccines are produced by covalently linking a bacterial polysaccharide (usually capsule, or more recently O-antigen), to a carrier ...
Emily Kay, Jon Cuccui, Brendan W. Wren
openaire   +3 more sources

FUCA2 Sustains AKT Signaling and Suppresses Senescence by Antagonizing FUT3‐Mediated ErbB3 Fucosylation in Lung Adenocarcinoma

Advanced Science, Volume 13, Issue 44, 7 August 2026.
ABSTRACT While targeted therapies have improved outcomes in lung adenocarcinoma (LUAD), many patients still lack targetable mutations. Here, we identified alpha‐L‐fucosidase 2 (FUCA2) as a crucial driver of LUAD by preventing cellular senescence. Mechanistically, through the restriction of fucosyltransferase 3 (FUT3)‐mediated α‐1,3‐fucosylation of ...
Lu Chen, Jintao Guo, Fei Li, Mingjie Gao, Runyang Li, Zhaozhang Huang, Yaolin Zheng, Chunyi Gao, Jihuan Hou, Qiang Yu, Bowen Zheng, Xuemei Chen, Wenqing Zhang, Xiaoting Hong, Yali Zheng, Daxuan Wang, Qiyuan Li, Tianhui Hu, Yan‐yan Zhan   +18 more
wiley   +1 more source

Modeling 1-Cyano-4-Dimethylaminopyridine Tetrafluoroborate (CDAP) Chemistry to Design Glycoconjugate Vaccines with Desired Structural and Immunological Characteristics

Vaccines
Glycoconjugation is a well-established technology for vaccine development: linkage of the polysaccharide (PS) antigen to an appropriate carrier protein overcomes the limitations of PS T-independent antigens, making them effective in infants and providing
Rebecca Nappini, Renzo Alfini, Salvatore Durante, Laura Salvini, Maria Michelina Raso, Elena Palmieri, Roberta Di Benedetto, Martina Carducci, Omar Rossi, Paola Cescutti, Francesca Micoli, Carlo Giannelli   +11 more
doaj   +1 more source

Application of the Hydrogen‐Bond‐Mediated Aglycone Delivery (HAD) Reaction to the Synthesis of α‐ and β‐Linked 2‐Azido‐2‐deoxyglucosides

Chemistry – An Asian Journal, Volume 21, Issue 15, 14 August 2026.
H‐bond‐mediated aglycone delivery method has been applied to the synthesis of glucosamine glycosides. ABSTRACT Controlling stereoselectivity of glycosylation reactions remains one of the central challenges in synthetic carbohydrate chemistry. In this study, we explore the impact of O‐picoloyl (Pico) protecting group positioning on the stereoselectivity
Alessandra Damico, Connor R. Mathus, Alexei V. Demchenko   +2 more
wiley   +1 more source

Aliphatic Poly(Carbonate)s with Acid Responsive Release Mechanisms for Micellar Anti‐Tumor Drug Delivery

Macromolecular Rapid Communications, Volume 47, Issue 14, 20 July 2026.
Micellar systems based on biodegradable aliphatic polycarbonates and acid‐responsive triggers enhance drug solubility, stability, and tumor‐selective release. This review covers micelles with acid‐cleavable drug linkages and those that disassemble via acid‐sensitive functionalities.
Adrian V. Hauck, Lutz Nuhn
wiley   +1 more source

Delivery Systems for Therapeutic Genome Editing: Challenges, Innovations, and Future Perspectives

MedComm, Volume 7, Issue 7, July 2026.
Schematic illustration of four emerging CRISPR–Cas delivery platforms defined by distinct design principles and structural features: virus‐mimicking nanosystems (e.g., VLPs), cell‐derived extracellular vesicles, cell‐penetrating peptides, and stimuli‐responsive scaffolds. These platforms enable spatiotemporally controlled delivery of RNPs, mRNA, or DNA
Meijia Yang, Yiqiong Song, Ziyang Wang, Ke Chao, Lifeng Li, Xu Zhang, Xiaoran Duan, Chenglong Yu, Ruyue Xue, Jie Zhao   +9 more
wiley   +1 more source

Substrate scope of ancestral versus modern family‐1 glycosidases

Protein Science, Volume 35, Issue 7, July 2026.
Abstract Experimental studies support that protein engineering based on ancestral sequence reconstruction often leads to variants with biotechnologically useful biomolecular properties. These may include high stability, enhanced conformational flexibility and a modified catalysis range.
Luis I. Gutierrez‐Rus, Dušan Petrović, Pascal Schneider, Katja Zorn, Gloria Gamiz‐Arco, Rocío Romero‐Zaliz, Ignacio Suarez‐Martin, Leonardo De Maria, Francesco Falcioni, Valeria A. Risso, Martin A. Hayes, Jose M. Sanchez‐Ruiz   +11 more
wiley   +1 more source