Carriers and Antigens: New Developments in Glycoconjugate Vaccines [PDF]
Vaccines, 2023 Glycoconjugate vaccines have proven their worth in the protection and prevention of infectious diseases. The introduction of the Haemophilus influenzae type b vaccine is the prime example, followed by other glycoconjugate vaccines.
Bernard Metz +2 more
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Conjugation Mechanism for Pneumococcal Glycoconjugate Vaccines: Classic and Emerging Methods [PDF]
Bioengineering, 2022 Licensed glycoconjugate vaccines are generally prepared using native or sized polysaccharides coupled to a carrier protein through random linkages along the polysaccharide chain.
Norma Suárez, Victor Morais
exaly +6 more sources
Recent Advances in the Biosynthesis of Polysaccharide-Based Antimicrobial Glycoconjugate Vaccines [PDF]
Frontiers in MicrobiologyGlycoconjugate vaccines are a vital category of effective and safe commercial vaccines that have significantly reduced the global prevalence of drug-resistant bacterial infections.
Haining Tan, Yuhan Di
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Impact and Control of Sugar Size in Glycoconjugate Vaccines [PDF]
Molecules, 2022 Glycoconjugate vaccines have contributed enormously to reducing and controlling encapsulated bacterial infections for over thirty years. Glycoconjugate vaccines are based on a carbohydrate antigen that is covalently linked to a carrier protein; this is ...
Giuseppe Stefanetti +2 more
doaj +4 more sources
Exploring the variables influencing the immune response of traditional and innovative glycoconjugate vaccines [PDF]
Frontiers in Molecular Biosciences, 2023 Vaccines are cost-effective tools for reducing morbidity and mortality caused by infectious diseases. The rapid evolution of pneumococcal conjugate vaccines, the introduction of tetravalent meningococcal conjugate vaccines, mass vaccination campaigns in ...
Francesca Micoli +4 more
doaj +4 more sources
Testing a Recombinant Form of Tetanus Toxoid as a Carrier Protein for Glycoconjugate Vaccines [PDF]
Vaccines, 2023 Glycoconjugate vaccines play a major role in the prevention of infectious diseases worldwide, with significant impact on global health, enabling the polysaccharides to induce immunogenicity in infants and immunological memory.
Davide Oldrini +14 more
doaj +3 more sources
Modeling 1-Cyano-4-Dimethylaminopyridine Tetrafluoroborate (CDAP) Chemistry to Design Glycoconjugate Vaccines with Desired Structural and Immunological Characteristics [PDF]
VaccinesGlycoconjugation is a well-established technology for vaccine development: linkage of the polysaccharide (PS) antigen to an appropriate carrier protein overcomes the limitations of PS T-independent antigens, making them effective in infants and providing
Rebecca Nappini +11 more
doaj +4 more sources
Exploitation of Bacterial N-Linked Glycosylation to Develop a Novel Recombinant Glycoconjugate Vaccine Against Francisella tularensis [PDF]
Open Biology, 2013 Glycoconjugate-based vaccines have proved to be effective at producing long-lasting protection against numerous pathogens. Here, we describe the application of bacterial protein glycan coupling technology (PGCT) to generate a novel recombinant ...
Thomas R Laws +2 more
exaly +4 more sources
Development of an automated platform for the optimal production of glycoconjugate vaccines expressed in Escherichia coli [PDF]
Microbial Cell Factories, 2021 Protein Glycan Coupling Technology (PGCT) uses purposely modified bacterial cells to produce recombinant glycoconjugate vaccines. This vaccine platform holds great potential in this context, namely due to its modular nature, the simplified production ...
Jasmin J. Samaras +4 more
doaj +4 more sources
Combined effects of glycan chain length and linkage type on the immunogenicity of glycoconjugate vaccines [PDF]
npj Vaccines, 2021 The development and use of antibacterial glycoconjugate vaccines have significantly reduced the occurrence of potentially fatal childhood and adult diseases such as bacteremia, bacterial meningitis, and pneumonia.
Chakkumkal Anish +2 more
doaj +2 more sources