Results 41 to 50 of about 220,176 (131)

Glycoconjugate vaccines: some observations on carrier and production methods [PDF]

, 2020
© 2019 Informa UK Limited, trading as Taylor & Francis Group. Glycoconjugate vaccines use protein carriers to improve the immune response to polysaccharide antigens.
MacCalman, Thomas E., Harding, Stephen E., Phillips-Jones, Mary K.   +2 more
core   +1 more source

Strain Selection for Generation of O-Antigen-Based Glycoconjugate Vaccines against Invasive Nontyphoidal Salmonella Disease. [PDF]

PLoS ONE, 2015
Nontyphoidal Salmonellae, principally S. Typhimurium and S. Enteritidis, are a major cause of invasive bloodstream infections in sub-Saharan Africa with no vaccine currently available.
Luisa Lanzilao, Giuseppe Stefanetti, Allan Saul, Calman A MacLennan, Francesca Micoli, Simona Rondini   +5 more
doaj   +1 more source

Analysis of the memory B cell response against glycoconjugate vaccines [PDF]

, 2012
The development of vaccines directed against polysaccharide capsules of S. pneumoniae, H. influenzae and N. meningitidis have been of great importance in preventing potentially fatal infections.
Faenzi, Elisa <1981>
core   +1 more source

Site-Specific Conjugation for Fully Controlled Glycoconjugate Vaccine Preparation

Frontiers in Chemistry, 2019
Glycoconjugate vaccines are formed by covalently link a carbohydrate antigen to a carrier protein whose role is to achieve a long lasting immune response directed against the carbohydrate antigen.
Aline Pillot, Aline Pillot, Alain Defontaine, Amina Fateh, Annie Lambert, Maruthi Prasanna, Maruthi Prasanna, Mathieu Fanuel, Muriel Pipelier, Noemi Csaba, Typhaine Violo, Emilie Camberlein, Cyrille Grandjean   +12 more
doaj   +1 more source

Synthetic BSA-conjugated disaccharide related to the Streptococcus pneumoniae serotype 3 capsular polysaccharide increases IL-17A Levels, γδ T cells, and B1 cells in mice

Frontiers in Immunology
The disaccharide (β-D-glucopyranosyluronic acid)-(1→4)-β-D-glucopyranoside represents a repeating unit of the capsular polysaccharide of Streptococcus pneumoniae serotype 3.
Nelli K. Akhmatova, Ekaterina A. Kurbatova, Anton E. Zaytsev, Elina A. Akhmatova, Natalya E. Yastrebova, Elena V. Sukhova, Dmitriy V. Yashunsky, Yury E. Tsvetkov, Nikolay E. Nifantiev   +8 more
doaj   +1 more source

Glycoconjugate vaccine containing Escherichia coli O157:H7 O-antigen linked with maltose-binding protein elicits humoral and cellular responses. [PDF]

PLoS ONE, 2014
Glycoconjugate is one of the most efficacious and safest vaccines against bacterial pathogens. Previous studies of glycoconjugates against pathogen E. coli O157:H7 focused more on the humoral responses they elicited. However, little was known about their
Zhongrui Ma, Huajie Zhang, Wenjing Shang, Faliang Zhu, Weiqing Han, Xueer Zhao, Donglei Han, Peng George Wang, Min Chen   +8 more
doaj   +1 more source

Chemoenzymatic Synthesis of Well‐Defined α(2,8)‐ and α(2,9)‐Linked Oligosialosides

Angewandte Chemie, Volume 138, Issue 36, 1 September 2026.
Well‐defined α(2,8)‐ and α(2,9)‐linked oligosialic acids of different lengths can be prepared by employing recombinant bacterial polysialyltransferases in combination with chemically modified CMP‐Neu5Ac derivatives. After transfer, a sialoside is formed bearing an artificial entity, which blocks further glycosylation.
Jelle A. Fok, Keshav Kishor, Mehman I. Bunyatov, Gerlof P. Bosman, Geert‐Jan Boons   +4 more
wiley   +2 more sources

Detaching Photosensitive Nanoparticles from Cells Prevents Them from Remaining in Cells after Photoporation

Advanced Science, EarlyView.
Phenylboronic acid‐functionalized gold nanoparticles reversibly attach to cell‐surface glycans, enhancing photoporation‐mediated intracellular delivery. After irradiation, ATP competitively disrupts the boronic ester interactions and removes cell‐associated nanoparticles, markedly reducing residual gold.
Tao Lu, Mina Nikolić, Baihao Huang, Deep Punj, Herlinde De Keersmaecker, Thibaut Van Acker, Wenjia Xie, Florian Vanlauwe, Phillip Blondeel, Liesl De Graeve, Félix Sauvage, Ranhua Xiong, Chaobo Huang, Frank Vanhaecke, Kevin Braeckmans, Stefaan C. De Smedt   +15 more
wiley   +1 more source

Retaining the structural integrity of disulfide bonds in diphtheria toxoid carrier protein is crucial for effectiveness of glycoconjugate vaccine candidates [PDF]

, 2022
The introduction of glycoconjugate vaccines marks an important point in the fight against various infectious diseases. The covalent conjugation of relevant polysaccharide antigens to immunogenic carrier proteins enables the induction of a long-lasting ...

core   +3 more sources

Production of glycoprotein vaccines in Escherichia coli

Microbial Cell Factories, 2010
Background Conjugate vaccines in which polysaccharide antigens are covalently linked to carrier proteins belong to the most effective and safest vaccines against bacterial pathogens.
Ihssen Julian, Kowarik Michael, Dilettoso Sandro, Tanner Cyril, Wacker Michael, Thöny-Meyer Linda   +5 more
doaj   +1 more source