Results 51 to 60 of about 220,176 (131)

ENGINEERING BACTERIAL GLYCOBIOLOGY FOR THE CREATION OF GLYCOCONJUGATE VACCINES [PDF]

, 2017
The use of vaccines has led to the effective eradication of several human diseases which were once epidemic such as smallpox and polio. Vaccines have also dramatically decreased the incidence of other diseases including rabies, mumps, and measles.
Stevenson, Taylor Currie
core   +1 more source

Analysis of Carbohydrates and Glycoconjugates by Matrix‐Assisted Laser Desorption/Ionization Mass Spectrometry: An Update for 2023–2024

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The use of MALDI mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this comprehensive review is the twelfth update of the original article published in 1999 and brings coverage of the literature to the end of 2024.
David J. Harvey
wiley   +1 more source

LECTINS IN ANTI-CANCER STRATEGIES

Acta Biomedica Scientifica, 2018
The published during last few years data concerning communicative role of lectins (proteins and their complexes which recognize  carbohydrates, glycoconjugates and their patterns) in on-duty  supporting and increasing anticancer status of human immunity ...
M. V. Lakhtin, V. M. Lakhtin, V. A. Aleshkin, M. S. Afanasiev, S. S. Afanasiev   +4 more
doaj   +1 more source

Structural and biological insights into Klebsiella pneumoniae surface polysaccharide degradation by a bacteriophage K1 lyase: implications for clinical use

Journal of Biomedical Science, 2022
Background K1 capsular polysaccharide (CPS)-associated Klebsiella pneumoniae is the primary cause of pyogenic liver abscesses (PLA) in Asia. Patients with PLA often have serious complications, ultimately leading to a mortality of ~ 5%.
I-Fan Tu, Tzu-Lung Lin, Feng-Ling Yang, I-Ming Lee, Wei-Lin Tu, Jiahn-Haur Liao, Tzu-Ping Ko, Wen-Jin Wu, Jia-Tsrong Jan, Meng-Ru Ho, Ching-Yi Chou, Andrew H.-J. Wang, Chung-Yi Wu, Jin-Town Wang, Kai-Fa Huang, Shih-Hsiung Wu   +15 more
doaj   +1 more source

THE IMPACT OF SALMONELLA POLYSACCHARIDE ANTIGENS STRUCTURE AND CONJUGATION CHEMISTRY ON NTS GLYCOCONJUGATE VACCINES [PDF]

, 2014
The Novartis Vaccines Institute for Global Health (NVGH) is working on the development of a bivalent glycoconjugate vaccine against nontyphoidal Salmonellae (NTS) covering the main serovars S. Typhimurium and S.
Stefanetti, Giuseppe
core   +1 more source

Role of Extracellular Vesicles in Shaping Immune Responses in the Lymph Node Microenvironment

Biology of the Cell, Volume 118, Issue 10, October 2026.
Functional alliances of stromal, innate and adaptive immune cells in EV immunity in the lymph node. EV reflect the phenotype of their mother cell and cluster material from their surroundings. In the lymph node, EV preserve valuable context information between multiple cellular effectors to coordinate immunity in adaption to change.
Alicia Charrier, Apolline Salama, Laurence Dubreil, Grégoire Mignot, Steffi Bosch   +4 more
wiley   +1 more source

An overview of structural features of antibacterial glycoconjugate vaccines that influence their immunogenicity

, 2017
Bacterial cell-surface-derived or mimicked carbohydrate moieties that act as protective antigens are used in the development of antibacterial glycoconjugate vaccines.
Khatun, Farjana, Stephenson, Rachel J., Toth, Istvan   +2 more
core   +1 more source

Synthetic O‐Polysaccharide Backbone Units for a Single Antigen Vaccine Against Two Major Non‐Typhoidal Salmonella Serovars

Angewandte Chemie, Volume 138, Issue 26, 22 June 2026.
A modular strategy was developed to synthesize tri‐, hexa‐, and nona‐saccharides representing repeating units of the conserved O‐polysaccharide backbone of Salmonella. Conjugates of these glycans to bacteriophage Qβ induced strong IgG responses in mice and rabbits. Antibodies elicited recognized native O‐polysaccharides and conferred protection against
Xingling Pan, Changxin Huo, Soham Maity, Herbert Kavunja, Rachel Moszyk, Cameron Talbot, Scott M. Baliban, Xuefei Huang   +7 more
wiley   +2 more sources

Maternal vaccination with a type-III glycoconjugate protects mouse neonates against Group B Streptococcus intranasal infection

Scientific Reports, 2021
Group B Streptococcus (GBS) is generally an asymptomatic colonizer of human mucosa but it occasionally infects pregnant women and neonates through vertical transmission, causing disease during the first weeks of life with frequent and severe ...
Emiliano Chiarot, Eleonora Naimo, Alessia Corrado, Patrizia Giannetti, Immaculada Margarit Y. Ros, Giuliano Bensi   +5 more
doaj   +1 more source

A Chemically Defined Four‐Component Self‐Adjuvanting Tn Vaccine Activating Mincle, FcγR, and CD206 for Enhanced Antitumor Immunity

Advanced Science, Volume 13, Issue 52, 18 September 2026.
A fully synthetic four‐component vaccine has been developed combining Tn antigen, vizantin (Mincle agonist), rhamnose (antibody recruitment), and mannose (CD206 targeting). By synergistically activating Mincle, FcγR, and CD206 pathways, it elicits strong IgG switching and cytotoxic T‐cells, significantly inhibiting tumors in mice.
Wenbo Ming, Renyu Zhang, Xiaohui Li, Guiqi Li, Yu Niu, Deying Yang, Xiang Luo, Jun Liao, Zhongqiu Liu, Guochao Liao   +9 more
wiley   +1 more source