Results 71 to 80 of about 220,176 (131)

Substrate scope of ancestral versus modern family‐1 glycosidases

Protein Science, Volume 35, Issue 7, July 2026.
Abstract Experimental studies support that protein engineering based on ancestral sequence reconstruction often leads to variants with biotechnologically useful biomolecular properties. These may include high stability, enhanced conformational flexibility and a modified catalysis range.
Luis I. Gutierrez‐Rus, Dušan Petrović, Pascal Schneider, Katja Zorn, Gloria Gamiz‐Arco, Rocío Romero‐Zaliz, Ignacio Suarez‐Martin, Leonardo De Maria, Francesco Falcioni, Valeria A. Risso, Martin A. Hayes, Jose M. Sanchez‐Ruiz   +11 more
wiley   +1 more source

Physicochemical characterisation of glycoconjugate vaccines for prevention of meningococcal diseases.

, 2008
Bacterial capsular polysaccharides covalently linked to an appropriate carrier protein represent the best tool to induce a protective immune response against a wide range of bacterial diseases, such as meningococcal infections.
Averani, Giovanni, Valeria Carinci, Proietti, Daniela, Magagnoli, Claudia, Sandro D’Ascenzi, Giannini, Sara, D'Ascenzi, Sandro, Berti, Francesco, Stefania Berti, Claudia Magagnoli, Daniela Proietti, Angela Bardotti, Berti, Stefania, Sara Giannini, Bardotti, Angela, Francesco Norelli, Barbara Fabbri, Carinci, Valeria, Rappuoli, Rino, Ricci, Stefano, Francesco Berti, Aldo Giannozzi, Rino Rappuoli, Costantino, Paolo, Giannozzi, Aldo, Stefano Ricci, Giovanni Averani, Norelli, Francesco, Fabbri, Barbara, Paolo Costantino   +29 more
core   +1 more source

Method for Simultaneous Quantitation of Free Carrier Protein and Free Polysaccharide in Glycoconjugate Vaccines by High Performance Liquid Chromatography [PDF]

, 2019
Disease caused by bacterial infections affect children and adults worldwide can be potentially life-threatening. Bacterial strains, such as Staphylococcus aureus and Streptococcus pnueumoniae (pneumococcus), express capsular polysaccharides on their ...
Hartzel, Ian
core   +1 more source

Meningococcal Vaccines: Current Status and Emerging Strategies

Vaccines, 2018
Neisseria meningitidis causes most cases of bacterial meningitis. Meningococcal meningitis is a public health burden to both developed and developing countries throughout the world.
Pumtiwitt C. McCarthy, Abeer Sharyan, Laleh Sheikhi Moghaddam   +2 more
doaj   +1 more source

Cancer cells and viruses share common glycoepitopes: exciting opportunities toward combined treatments

Frontiers in Immunology
Aberrant glycosylation patterns of glycoproteins and glycolipids have long been recognized as one the major hallmarks of cancer cells that has led to numerous glycoconjugate vaccine attempts.
René Roy
doaj   +1 more source

Mutagenesis and immunological evaluation of group A streptococcal C5a peptidase as an antigen for vaccine development and as a carrier protein for glycoconjugate vaccine design

, 2017
A non-enzymatic recombinant ScpA mutant (H193A) was prepared and investigated to probe its application potential in the development of GAS vaccines and as a carrier protein of glycoconjugate vaccines.
Zhongwu Guo, Subo Wang, Zonggang Chen, Hui Li, Yisheng Zhao, Guofeng Gu   +5 more
core   +1 more source

Vaccines based on the cell surface carbohydrates of pathogenic bacteria

Anais da Academia Brasileira de Ciências, 2005
Glycoconjugate vaccines, in which a cell surface carbohydrate from a micro-organism is covalently attached to an appropriate carrier protein are proving to be the most effective means to generate protective immune responses to prevent a wide range of ...
Jones Christopher
doaj  

An asymmetric and slightly dimerized structure for the tetanus toxoid protein used in glycoconjugate vaccines

, 2012
Tetanus toxoid protein has been characterized with regard oligomeric state and hydrodynamic (low-resolution) shape, important parameters with regard its use in glycoconjugate vaccines. From sedimentation velocity and sedimentation equilibrium analysis in
Harding, Stephen E., Gordon A. Morris, Conrath, K., Benjamin Bonnier, Cerny, L., Laloux, O., Olivier Laloux, Rowe, A. J., Bonnier, B., Louis Cerny, Adams, G. G., Morris, Gordon, Lenfant, C., Pierre Duvivier, Christophe Lenfant, Duvivier, P., Gary G. Adams, Ali Saber Abdelhameed, Stephen E. Harding, Abdelhameed, A. S., Arthur J. Rowe, Karel Conrath   +21 more
core   +1 more source

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

Development of an Efficacious, Semisynthetic Glycoconjugate Vaccine Candidate against Streptococcus pneumoniae Serotype 1

, 2018
Infections with Streptococcus pneumoniae are a major health burden. Glycoconjugate vaccines based on capsular polysaccharides (CPSs) successfully protect from infection, but not all pneumococcal serotypes are covered with equal potency.
Martin Witzenrath (167419), Katrin Reppe (599647), Peter H. Seeberger (255011), Benjamin Schumann (4841256), Annette Wahlbrink (1819207), Chakkumkal Anish (1458835), Paulina Kaplonek (3856054), Claney L. Pereira (1458829)   +7 more
core   +2 more sources