Results 61 to 70 of about 220,176 (131)

Optimization of Burkholderia Glycoconjugate Vaccines: A Reverse Vaccinology Approach [PDF]

, 2019
Burkholderia pseudomallei is a Gram-negative, intracellular pathogen and the etiological agent of melioidosis. Because of intrinsic multi-drug resistance, lack of effective treatment and high case-fatality rates, this organism is classified as a Tier 1 ...
Muruato, Laura Anne
core  

Meningococcal vaccine evolution

Clinical Management Issues, 2012
Neisseria meningitidis is a leading cause of bacterial sepsis and meningitis worldwide. Although polysaccharide and glycoconjugate vaccines have been developed for serogroups A, C, Y and W-135, currently there are no broadly effective vaccines available ...
Gianni Bona, Carla Guidi
doaj   +1 more source

FUCA2 Sustains AKT Signaling and Suppresses Senescence by Antagonizing FUT3‐Mediated ErbB3 Fucosylation in Lung Adenocarcinoma

Advanced Science, Volume 13, Issue 44, 7 August 2026.
ABSTRACT While targeted therapies have improved outcomes in lung adenocarcinoma (LUAD), many patients still lack targetable mutations. Here, we identified alpha‐L‐fucosidase 2 (FUCA2) as a crucial driver of LUAD by preventing cellular senescence. Mechanistically, through the restriction of fucosyltransferase 3 (FUT3)‐mediated α‐1,3‐fucosylation of ...
Lu Chen, Jintao Guo, Fei Li, Mingjie Gao, Runyang Li, Zhaozhang Huang, Yaolin Zheng, Chunyi Gao, Jihuan Hou, Qiang Yu, Bowen Zheng, Xuemei Chen, Wenqing Zhang, Xiaoting Hong, Yali Zheng, Daxuan Wang, Qiyuan Li, Tianhui Hu, Yan‐yan Zhan   +18 more
wiley   +1 more source

Application of the Hydrogen‐Bond‐Mediated Aglycone Delivery (HAD) Reaction to the Synthesis of α‐ and β‐Linked 2‐Azido‐2‐deoxyglucosides

Chemistry – An Asian Journal, Volume 21, Issue 15, 14 August 2026.
H‐bond‐mediated aglycone delivery method has been applied to the synthesis of glucosamine glycosides. ABSTRACT Controlling stereoselectivity of glycosylation reactions remains one of the central challenges in synthetic carbohydrate chemistry. In this study, we explore the impact of O‐picoloyl (Pico) protecting group positioning on the stereoselectivity
Alessandra Damico, Connor R. Mathus, Alexei V. Demchenko   +2 more
wiley   +1 more source

Towards a platform process for the manufacture of glycoconjugate vaccines for pneumococcal disease

, 2022
Streptococcus pneumoniae (S. pneumoniae) is one of the leading causes of invasive bacterial disease in children where infection results in pneumonia and meningitis.
Cuccui, Dr. Jon, Sulu, Dr. Michael, Kay, Dr. Emily, Baganz, Dr. Frank, Patel, Neha   +4 more
core   +1 more source

Evaluation of Glycosylated FlpA and SodB as Subunit Vaccines Against Campylobacter jejuni Colonisation in Chickens

Vaccines, 2020
Campylobacter jejuni is the leading bacterial cause of human gastroenteritis worldwide and the handling or consumption of contaminated poultry meat is the key source of infection. C.
Prerna Vohra, Cosmin Chintoan-Uta, Vanessa S. Terra, Abi Bremner, Jon Cuccui, Brendan W. Wren, Lonneke Vervelde, Mark P. Stevens   +7 more
doaj   +1 more source

Aliphatic Poly(Carbonate)s with Acid Responsive Release Mechanisms for Micellar Anti‐Tumor Drug Delivery

Macromolecular Rapid Communications, Volume 47, Issue 14, 20 July 2026.
Micellar systems based on biodegradable aliphatic polycarbonates and acid‐responsive triggers enhance drug solubility, stability, and tumor‐selective release. This review covers micelles with acid‐cleavable drug linkages and those that disassemble via acid‐sensitive functionalities.
Adrian V. Hauck, Lutz Nuhn
wiley   +1 more source

Delivery Systems for Therapeutic Genome Editing: Challenges, Innovations, and Future Perspectives

MedComm, Volume 7, Issue 7, July 2026.
Schematic illustration of four emerging CRISPR–Cas delivery platforms defined by distinct design principles and structural features: virus‐mimicking nanosystems (e.g., VLPs), cell‐derived extracellular vesicles, cell‐penetrating peptides, and stimuli‐responsive scaffolds. These platforms enable spatiotemporally controlled delivery of RNPs, mRNA, or DNA
Meijia Yang, Yiqiong Song, Ziyang Wang, Ke Chao, Lifeng Li, Xu Zhang, Xiaoran Duan, Chenglong Yu, Ruyue Xue, Jie Zhao   +9 more
wiley   +1 more source

Simulating Immune Interference on the Effect of a Bivalent Glycoconjugate Vaccine against Haemophilus influenzae Serotypes “a” and “b”

Canadian Journal of Infectious Diseases and Medical Microbiology, 2016
Objective. We sought to evaluate the immune responses to a bivalent Haemophilus influenzae glycoconjugate vaccine against serotypes “a” (Hia) and “b” (Hib) in the presence of the preexisting immunity to Hib. Methods.
Angjelina Konini, Mingsong Kang, Seyed M. Moghadas   +2 more
doaj   +1 more source

Immunogenicity and Induction of Functional Antibodies in Rabbits Immunized with a Trivalent Typhoid-Invasive Nontyphoidal Salmonella Glycoconjugate Formulation

Molecules, 2018
Typhoid fever due to Salmonella Typhi and invasive nontyphoidal Salmonella (iNTS) infections caused by serovars Enteritidis (SE) and Typhimurium (STm) are major pediatric health problems in sub-Saharan Africa.
Scott M. Baliban, Jessica C. Allen, Brittany Curtis, Mohammed N. Amin, Andrew Lees, R. Nageswara Rao, Gangadhara Naidu, Ramasamy Venkatesan, D. Yogeswara Rao, Vadrevu Krishna Mohan, Krishna M. Ella, Myron M. Levine, Raphael Simon   +12 more
doaj   +1 more source