Results 11 to 20 of about 2,336 (164)

Design of a Glycoconjugate Vaccine Against Salmonella Paratyphi A [PDF]

Vaccines
Background/Objectives: Typhoid and paratyphoid fever together are responsible for millions of cases and thousands of deaths per year, most of which occur in children in South and Southeast Asia.
Renzo Alfini, Martina Carducci, Luisa Massai, Daniele De Simone, Marco Mariti, Omar Rossi, Simona Rondini, Francesca Micoli, Carlo Giannelli   +8 more
doaj   +2 more sources

Recent Advances in the Biosynthesis of Polysaccharide-Based Antimicrobial Glycoconjugate Vaccines

Frontiers in Microbiology
Glycoconjugate vaccines are a vital category of effective and safe commercial vaccines that have significantly reduced the global prevalence of drug-resistant bacterial infections.
Haining Tan, Yuhan Di
exaly   +3 more sources

An O-Antigen Glycoconjugate Vaccine Produced Using Protein Glycan Coupling Technology Is Protective in an Inhalational Rat Model of Tularemia [PDF]

Journal of Immunology Research, 2018
There is a requirement for an efficacious vaccine to protect people against infection from Francisella tularensis, the etiological agent of tularemia. The lipopolysaccharide (LPS) of F.
Laura E. Marshall, Michelle Nelson, Carwyn H. Davies, Adam O. Whelan, Dominic C. Jenner, Madeleine G. Moule, Carmen Denman, Jon Cuccui, Timothy P. Atkins, Brendan W. Wren, Joann L. Prior   +10 more
doaj   +2 more sources

Using Synthetic Glycans to Investigate Anti-Glycan Antibodies and Explore Their Medical Potential. [PDF]

Angew Chem Int Ed Engl
Anti‐glycan antibodies are essential in health and disease. Access to novel glycan structures paves the way for progress in antibody profiling for biomarker discovery, antibody development, and vaccine design. We summarize the strategies to synthesize and utilize synthetic glycans for the development and application of anti‐glycan antibodies in basic ...
Weber F, Valenti A, Ledvinka J, Moscovitz O, Seeberger PH.   +4 more
europepmc   +2 more sources

Development and evaluation of a dual-target glycoconjugate against Shigella sonnei [PDF]

Frontiers in Immunology
IntroductionShigellosis morbidity and mortality, combined with the increase in multidrug-resistant infections, make Shigella vaccine development a global imperative.
Catherine L. Hall, Tom L. Flood, Simon Clare, Katherine Harcourt, Emily J. Kay, Stephen Baker, Brendan W. Wren   +6 more
doaj   +2 more sources

Development and Protective Evaluation of an O18–CRM197 Glycoconjugate Candidate Preparation Against APEC O18 Challenge in SPF Chickens [PDF]

Microorganisms
Avian pathogenic Escherichia coli (APEC) is an important cause of colibacillosis in poultry, and increasing antimicrobial resistance has highlighted the need for alternative preventive strategies.
Tingfan Zhu, Jing Yuan, Kangmei Feng, Hairui Bai, Caihong Yan, Yang Yang, Aijian Qin, Wenjie Jin   +7 more
doaj   +2 more sources

Maternal Antibodies Elicited by Immunization With an O- Polysaccharide Glycoconjugate Vaccine Protect Infant Mice Against Lethal Salmonella Typhimurium Infection [PDF]

Frontiers in Immunology, 2019
Non-typhoidal Salmonella (NTS) are a leading cause of pediatric invasive bacterial infections in sub-Saharan Africa with high associated case fatality rates in children under 5 years old.
Scott M. Baliban, Scott M. Baliban, Brittany Curtis, Brittany Curtis, Mohammed N. Amin, Mohammed N. Amin, Myron Mike Levine, Myron Mike Levine, Myron Mike Levine, Marcela F. Pasetti, Marcela F. Pasetti, Raphael Simon, Raphael Simon   +12 more
doaj   +2 more sources

A Semisynthetic Oligomannuronic Acid-Based Glycoconjugate Vaccine against Pseudomonas aeruginosa [PDF]

ACS Central Science
Yiyue Zhang, Xiaotong Wang, Youling Liang, Liangliang Zhang, Jiahao Fan, You Yang   +5 more
doaj   +2 more sources

Development of an automated platform for the optimal production of glycoconjugate vaccines expressed in Escherichia coli

Microbial Cell Factories, 2021
Protein Glycan Coupling Technology (PGCT) uses purposely modified bacterial cells to produce recombinant glycoconjugate vaccines. This vaccine platform holds great potential in this context, namely due to its modular nature, the simplified production ...
Jasmin J. Samaras, Marta Mauri, Emily J. Kay, Brendan W. Wren, Martina Micheletti   +4 more
doaj   +1 more source

Meningococcal glycoconjugate vaccines [PDF]

Human Vaccines, 2011
Neisseria meningitidis is a major cause of invasive bacterial infections worldwide. For this reason, efforts to control the disease have been directed at optimizing meningococcal vaccines and implementing appropriate vaccination policies. In the past, plain polysaccharide vaccines containing purified capsular polysaccharides A, C, Y and W135 were ...
GASPARINI, ROBERTO, PANATTO, DONATELLA
openaire   +2 more sources