Results 1 to 10 of about 4,482,895 (292)

Evaluation of Cholera Toxin B Subunit as a Novel Carrier Protein for Polysaccharide Conjugate Vaccines [PDF]

Vaccines
Background: The immunogenicity of polysaccharide conjugate vaccines is critically influenced by the choice of carrier protein, which promotes a T-cell-dependent immune response mechanism leading to strong antibody production.
Chathuranga Siriwardhana, Aakriti Bajracharya, Florence Seal, Anup Datta, Subhash Kapre   +4 more
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Testing a Recombinant Form of Tetanus Toxoid as a Carrier Protein for Glycoconjugate Vaccines [PDF]

Vaccines, 2023
Glycoconjugate vaccines play a major role in the prevention of infectious diseases worldwide, with significant impact on global health, enabling the polysaccharides to induce immunogenicity in infants and immunological memory.
Davide Oldrini, Roberta Di Benedetto, Martina Carducci, Daniele De Simone, Luisa Massai, Renzo Alfini, Barbara Galli, Brunella Brunelli, Amanda Przedpelski, Joseph T. Barbieri, Omar Rossi, Carlo Giannelli, Rino Rappuoli, Francesco Berti, Francesca Micoli   +14 more
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Human Metapneumovirus G Protein Immunogenicity and Safety Explored via Carrier Protein Fusion [PDF]

Tropical Medicine and Infectious Disease
Human metapneumovirus (HPMV) is a significant pathogen that causes lower respiratory tract infections. Given the weak immunogenicity thereof, and the few relevant studies, the utility of the viral membrane protein G as a vaccine remains controversial. In
Tian Ren, Kailun Ma, Xinmiao Lai, Jizheng Chen, Changgui Li   +4 more
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A broad inhibitor of acyl-acyl carrier protein synthetases [PDF]

Biochemistry and Biophysics Reports, 2023
The acyl-acyl carrier protein synthetase enzyme enables some bacteria to scavenge free fatty acids from the environment for direct use in lipids. This fatty acid recycling pathway can help pathogens circumvent fatty acid synthase (FAS) inhibition with ...
Magdalena Todorinova, Joris Beld, Kara L. Jaremko   +2 more
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Carrier-Protein-Free Pneumococcal Glycoconjugate Vaccines Enabled by SPAAC: Serotype 15C CPS–PADRE Conjugates and the Impact of an RR Cleavage Motif [PDF]

Vaccines
Background/Objectives: Polysaccharide-protein conjugate vaccines have proven highly effective, yet they remain limited by manufacturing complexity, cost, and variable performance across serotypes, while carrier proteins can add unwanted immunological and
Huimin Yang, Zeyu Liao, Yingjie Zhong, Qi Gao, Hangqi Zhang, Chengli Zong   +5 more
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Generalized Modules for Membrane Antigens as Carrier for Polysaccharides: Impact of Sugar Length, Density, and Attachment Site on the Immune Response Elicited in Animal Models

Frontiers in Immunology, 2021
Nanoparticle systems are being explored for the display of carbohydrate antigens, characterized by multimeric presentation of glycan epitopes and special chemico-physical properties of nano-sized particles.
Francesca Micoli, Renzo Alfini, Roberta Di Benedetto, Francesca Necchi, Fabiola Schiavo, Francesca Mancini, Martina Carducci, Davide Oldrini, Olimpia Pitirollo, Gianmarco Gasperini, Cristiana Balocchi, Nicoletta Bechi, Brunella Brunelli, Diego Piccioli, Roberto Adamo   +14 more
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Characterization of Phosphopantetheinyl Hydrolase from Mycobacterium tuberculosis

Microbiology Spectrum, 2021
Phosphopantetheinyl hydrolase, PptH (Rv2795c), is a recently discovered enzyme from Mycobacterium tuberculosis that removes 4′-phosphopantetheine (Ppt) from holo-carrier proteins (CPs) and thereby opposes the action of phosphopantetheinyl transferases ...
Shilpika Pandey, Amrita Singh, Guangli Yang, Felipe B. d’Andrea, Xiuju Jiang, Travis E. Hartman, John W. Mosior, Ronnie Bourland, Ben Gold, Julia Roberts, Annie Geiger, Su Tang, Kyu Rhee, Ouathek Ouerfelli, James C. Sacchettini, Carl F. Nathan, Kristin Burns-Huang   +16 more
doaj   +1 more source

Post-marketing safety surveillance for both CRM197 and TT carrier proteins PCV13 in Jiangsu, China

Frontiers in Public Health, 2023
BackgroundThis study is to evaluate the safety of two kinds of PCV13 carriers by monitoring the occurrence of adverse event following immunization (AEFI) after the launch of two kinds of PCV13 carriers in Jiangsu Province, China.MethodsThe AEFI ...
Ran Hu, Yuanbao Liu, Lei Zhang, Guodong Kang, Borong Xu, Mingma Li, Jing Yu, Yuanyuan Zhu, Hongxiong Guo, Zhiguo Wang   +9 more
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Immunogenicity Assessment of Different Segments and Domains of Group A Streptococcal C5a Peptidase and Their Application Potential as Carrier Protein for Glycoconjugate Vaccine Development

Vaccines, 2021
Group A streptococcal C5a peptidase (ScpA) is a highly conserved surface virulence factor present on group A streptococcus (GAS) cell surfaces. It has attracted much more attention as a promising antigenic target for GAS vaccine development due to its ...
Guirong Wang, Jielin Zhao, Yisheng Zhao, Subo Wang, Shaojie Feng, Guofeng Gu   +5 more
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Differential Effects of Exogenous Glomalin-Related Soil Proteins on Plant Growth of Trifoliate Orange Through Regulating Auxin Changes

Frontiers in Plant Science, 2021
Multiple functions of glomalin released by arbuscular mycorrhizal fungi are well-recognized, whereas the role of exogenous glomalins including easily extractable glomalin-related soil protein (EE-GRSP) and difficultly extractable glomalin-related soil ...
Rui-Cheng Liu, Wei-Qin Gao, Anoop Kumar Srivastava, Ying-Ning Zou, Kamil Kuča, Abeer Hashem, Elsayed Fathi Abd_Allah, Qiang-Sheng Wu, Qiang-Sheng Wu   +8 more
doaj   +1 more source